Oral administration of lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance

Abstract

We concluded that oral administration of lactoferrin exerts a protective effect against the development of colitis in rats via modulation of the immune system and correction of cytokine imbalance. Lactoferrin has potential as a new therapeutic agent for inflammatory bowel disease.

On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease

“…In agreement with published data [39][40][41][42][43][44] , the DAI increased gradually over the time of DSS administration, reaching a maximum of 3.11 ± 0.05 on the last day of DSS administration (day 7), and subsequently decreased to 1.55 ± 0.17 at the 4 th day after DSS cessation. The full DAI time course is shown in Fig.1.…”

Histomorphometric study of role of lactoferrin in atrophy of the intestinal mucosa of rats

“…Groups CL and SL received 200 mg/kg lactoferrin (Bioferrin 1000 ® , Apolactoferrin, Glanbia Nutritionals, Carlsbad, USA) dissolved in 1.0 mL of distilled water (200 mg/mL) by gavage, once daily. The dose and method of administration were based on other experiments [18][19][20][21].…”

Lactoferrin as an Adjunctive Agent in the Treatment of Bacterial Infections Associated with Diabetic Foot Ulcers

“…The modulatory activity of lactoferrin in inflammation has been addressed in animal models, such as that of colitis induced by dextran sulfate (Håversen et al, 2003A;Togawa et al, 2002) and that of hind-foot inflammation by carrageenan (Zimecki et al, 1998). This modulatory activity has also been assessed under in vitro and in vivo conditions by using LPS as an inducer (Puddu et al, 2010).…”

“…The effects of lactoferrin on inflammation have been correlated with a decrease in three proinflammatory mediators: TNF (Håversen et al, 2003A;Togawa et al, 2002;Zimecki et al, 1998), IL 6 (Togawa et al, 2002;Zimecki et al, 1998) and IL 1 (Togawa et al, 2002). These effects have also been associated, in some cases, with an increase in two anti-inflammatory interleukins: IL 4 and IL 10 (Togawa et al, 2002).…”

“…These effects have also been associated, in some cases, with an increase in two anti-inflammatory interleukins: IL 4 and IL 10 (Togawa et al, 2002). In animal models of infection with Shigella flexneri (Gómez et al, 2002), Salmonella typhimurium (Mosquito et al, 2010) and Lysteria monocytogenes (Lee et al, 2005), lactoferrin from bovine or human origin has been effective in reducing inflammatory necrosis in liver (Lee et al, 2005) and intestine (Mosquito et al, 2010), as well as in intestinal edema (Gomez et al, 2002).…”