On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease

Saijo, Fumito; Milsom, Alexandra; Bryan, Nathan S.; Bauer, Selena; Vowinkel, Thorsten; Ivanovic, Marina; Andry, Chris; Granger, D. Neil; Rodríguez, Juan; Feelisch, Martin

doi:10.1016/j.niox.2009.11.009

Cited by 39 publications

(27 citation statements)

References 70 publications

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“…Both 5-aminosalicylic acid and thiopurines were found to decrease NO in the intestine through inhibition or decrease of iNO synthase expression [40][41][42]. Whether it also decreases NO in other organs (specifically the airways) is unknown, although any effect on FeNO levels would have made the difference between IBD patients and the control group even higher.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary functions in children with inflammatory bowel disease

Gut

Ben‐Tov²,

Lahad³

et al. 2016

European Journal of Gastroenterology &Amp; Hepatology

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Section: Discussionmentioning

confidence: 99%

Pulmonary functions in children with inflammatory bowel disease

Gut

Ben‐Tov²,

Lahad³

et al. 2016

European Journal of Gastroenterology &Amp; Hepatology

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“…Innate immune pathway activation in response to infection and inflammation, particularly in sepsis and shock, is associated with increased activity of iNOS, and thus more NO being released [20, 71]. However, studies in experimental animals reveal that iNOS upregulation and production of NO may have a feedback inhibition on constitutive NO production in other tissues [21, 72]. Urinary NOx reflects both the production and utilization of NO [73, 74].…”

Section: No and Its Metabolites In Acute Disease Processesmentioning

confidence: 99%

Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making

Mian

Aranke²,

Bryan

2013

Open Biochem J

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The potential of nitric oxide (NO) as a rapid assay biomarker, one that could provide a quantum leap in acute care, remains largely untapped. NO plays a crucial role as bronchodilator, vasodilator and inflammatory mediator. The main objective of this review is to demonstrate how NO is a molecule of heavy interest in various acute disease states along the emergency department and critical care spectrum: respiratory infections, central nervous system infections, asthma, acute kidney injury, sepsis, septic shock, and myocardial ischemia, to name just a few. We discuss how NO and its oxidative metabolites, nitrite and nitrate, are readily detectable in several body compartments and fluids, and as such they are associated with many of the pathophysiological processes mentioned above. With methods such as high performance liquid chromatography and chemiluminescence these entities are relatively easy and inexpensive to analyze. Emphasis is placed on diagnostic rapidity, as this relates directly to quality of care in acute care situations. Further, a rationale is provided for more bench, translational and clinical research in the field of NO biomarkers for such settings. Developing standard protocols for the aforementioned disease states, centered on concentrations of NO and its metabolites, can prove to revolutionize diagnostics and prognostication along a spectrum of clinical care. We present a strong case for developing these biomarkers more as point-of-care assays with potential of color gradient test strips for rapid screening of disease entities in acute care and beyond. This will be relevant to global health.

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“…Saijo et al examined tissue and plasma nitroso species in both the acute and chronic dextran sodium sulfate (DSS) induced rat colitis model [234]. This study found that the development of DSS colitis involves an early loss of colon tissue nitrite levels with a concomitant increase in systemic nitrite.…”

Section: Sodium Nitrite Therapy For Inflammatory Diseasesmentioning

confidence: 99%

Inorganic nitrite therapy: historical perspective and future directions

Kevil

Kolluru

Pattillo

et al. 2011

Free Radical Biology and Medicine

103

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Over the past several years, investigators studying nitric oxide (NO) biology and metabolism have come to learn that the one electron oxidation product of NO, nitrite anion, serves as a unique player in modulating tissue NO bioavailability. Numerous studies have examined how this oxidized metabolite of NO can act as a salvage pathway for maintaining NO equivalents through multiple reduction mechanisms in permissive tissue environments. Moreover, it is now clear that nitrite anion production and distribution throughout the body can act in an endocrine manner to augment NO bioavailability that is important for physiological and pathological processes. These discoveries have led to renewed hope and efforts for an effective NO based therapeutic agent through the unique action of sodium nitrite as an NO pro-drug. More recent studies also indicate that sodium nitrate may also increase plasma nitrite levels via the enterosalivary circulatory system resulting in nitrate reduction to nitrite by microorganisms found within the oral cavity. In this review, we discuss the importance of nitrite anion in several disease models along with an appraisal of sodium nitrite therapy in the clinic, potential caveats of such clinical uses, and future possibilities of nitrite based therapies.

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On the dynamics of nitrite, nitrate and other biomarkers of nitric oxide production in inflammatory bowel disease

Cited by 39 publications

References 70 publications

Pulmonary functions in children with inflammatory bowel disease

Pulmonary functions in children with inflammatory bowel disease

Nitric Oxide and its Metabolites in the Critical Phase of Illness: Rapid Biomarkers in the Making

Inorganic nitrite therapy: historical perspective and future directions

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