Oral administration of Lactobacillus strains from Kimchi inhibits atopic dermatitis in NC / Nga mice

Abstract

Aims: Atopic dermatitis (AD) is marked by elevated levels of immunoglobulin E and skin lesions such as oedema and haemorrhage. Kimchi is a Korean fermented food that contains beneficial bacteria for human health. In this study, Lactobacillus plantarum CJLP55, CJLP56, CJLP133 and CJLP136 isolated from Kimchi were investigated for their capacity to inhibit AD. Methods and Results: The three strains, CJLP55, CJLP133 and CJLP136, suppressed AD‐like skin lesions, high serum IgE levels and epidermal thickening. The three strains diminished the accumulation of eosinophils and mast cells into topical inflammatory sites and the enlargement of axillary lymph nodes, which are responsible for the dorsal dermatitis. CJLP55, CJLP133 and CJLP136 decreased production of type 2 cytokines such as IL‐4 and IL‐5 in lymph node cell culture. CJLP133 and CJLP136 increased IFN‐γ secretion, while CJLP55 enhanced IL‐10 production. Conclusions: The three strains isolated from Kimchi suppress house‐dust mite‐induced dermatitis in NC/Nga mouse, a representative animal model of human AD. Significance and Impact of the Study: These findings suggest that lactobacilli isolated from Kimchi inhibit AD, probably by altering the balance of Th1/Th2 ratio or inducing IL‐10 production.

RETRACTED: Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders: An Up-to-Date Literature Review of Essential Experimental and Clinical Data

“…Lactobacilli isolated from Kimchi inhibit atopic dermatitis, probably by altering the balance of Th1/Th2 ratio or inducing IL-10 production. 60 A new synbiotic, Lactobacillus casei subsp casei together with dextran, reduces the development of atopic dermatitis-like skin lesions in NC/Nga mice. This synbiotic combination significantly decreased clinical skin severity scores induced by picryl chloride and total IgE levels in sera of NC/Nga mice.…”

Tannic acid modulates NFκB signaling pathway and skin inflammation in NC/Nga mice through PPARγ expression

“…Although the pathogenesis of AD is complicated, infiltration of immune cells such as mast cells, neutrophils, eosinophils, and lymphocytes are elevated in disease state [1]. In addition, serum immunoglobulin E (IgE) levels are elevated in AD [2].…”

Microbes taming mast cells: Implications for allergic inflammation and beyond

“…L. rhamnousus JB-1, could attenuate an allergen induced allergic airway response in adult mice (Forsythe et al, 2007;Karimi et al, 2009) and others have since confirmed these antiallergic effects in the airway using a variety of bacteria (Lim et al, 2009;Adam et al, 2010;Li et al, 2010). In addition, several strains of lactobacillus have been shown to attenuate allergic dermatitis when administered orally to mice (Inoue et al, 2007;Hacini-Rachinel et al, 2009;Won et al, 2011). A number of mechanisms have been identified that may contribute to the ability of these bacteria to attenuate allergic inflammation including altered antigen presentation by dendritic cells Stagg et al, 2004), Th1 polarization (Adel-Patient et al, 2005;Hisbergues et al, 2007) or the induction of regulatory T cells (Karimi et al, 2009(Karimi et al, , 2012.…”