Microbes taming mast cells: Implications for allergic inflammation and beyond

Forsythe, Paul

doi:10.1016/j.ejphar.2015.06.034

Cited by 24 publications

(16 citation statements)

References 95 publications

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“…Microbes can also influence inflammatory responses in food allergy and particular the secondary effector phase of the allergic response. Patients suffering from allergic dermatitis display a different microbiota of the skin compared to healthy controls and in a mouse study it was shown that mast cells mediate Staphylococcus aureus delta‐toxin induced atopic dermatitis by attenuating mast cell activation and degranulation . These findings show that a direct interaction between microbiota and mast cells and T‐cells might support the observed reduction in mast cell degranulation and allergic symptoms in mice fed the non‐digestible oligosaccharides and B. breve .…”

Section: Discussionmentioning

confidence: 80%

Post‐sensitization administration of non‐digestible oligosaccharides and Bifidobacterium breve M‐16V reduces allergic symptoms in mice

Esch

Abbring

Diks

et al. 2016

Immunity Inflam & Disease

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To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non‐digestible oligosaccharides and Bifidobacterium breve M‐16V (B. breve) was designed from source materials that are completely cow's milk‐free. It was investigated whether this specific synbiotic concept can reduce an established food allergic response in a research model for hen's egg allergy. Mice were orally sensitized once a week for 5 weeks to ovalbumin (OVA) using cholera toxin (CT) as an adjuvant. Non‐sensitized mice received CT in PBS only. Sensitized mice were fed a control diet or a diet enriched with short‐chain‐ (scFOS) and long‐chain fructo‐oligosaccharides (lcFOS), B. breve or scFOSlcFOS + B. breve for 3 weeks starting after the last sensitization. Non‐sensitized mice received the control diet. Anaphylactic shock symptoms, acute allergic skin responses and serum specific IgE, mMCP‐1 and galectin‐9 were measured upon OVA challenge. Activated Th2‐, Th1‐cells and regulatory T‐cells were quantified in spleen and mesenteric lymph nodes (MLN) and cytokine profiles were analyzed. Short chain fatty acids (SCFA) were measured in ceacal samples. The acute allergic skin response was reduced in mice fed the scFOSlcFOS + B. breve diet compared to mice fed any of the other diets. A reduction in mast cell degranulation (mMCP‐1) and anaphylactic shock symptoms was also observed in these mice. Unstimulated splenocyte cultures produced increased levels of IL10 and IFNg in mice fed the scFOSlcFOS + B. breve diet. Correspondingly, increased percentages of activated Th1 cells were observed in the spleen. Allergen‐specific re‐stimulation of splenocytes showed a decrease in IL5 production. In summary; post‐sensitization administration of scFOSlcFOS + B. breve was effective in reducing allergic symptoms after allergen challenge. These effects coincided with changes in regulatory and effector T‐cell subsets and increases in the SCFA propionic acid. These results suggest immune modulatory benefits of dietary intervention with a unique combination of scFOSlcFOS + B. breve in established food allergy. Whether these effects translate to human applications is subject for ongoing clinical studies.

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Section: Discussionmentioning

confidence: 80%

Post‐sensitization administration of non‐digestible oligosaccharides and Bifidobacterium breve M‐16V reduces allergic symptoms in mice

Esch

Abbring

Diks

et al. 2016

Immunity Inflam & Disease

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“…Microorganisms may influence MC activation via direct interaction or via secreted metabolites. For example, co‐culture with Lactobacillus rhamnosus (Figure C) downregulates gene expression for the high‐affinity IgE receptor and histamine H4 receptor in human MC, while increasing IL‐8, IL‐10, CCL2, and TNF‐α . Stabilization of MC by L rhamnosus is possibly induced indirectly via targeting the KCa3.1 channel .…”

Section: Microbiota Regulating Cellular Players In Innate and Adaptivmentioning

confidence: 99%

“…They also play important roles in regulating the microenvironment of various tumors . There is increasing evidence that MC function can be modulated by commensal, symbiotic, and pathogenic microorganisms . Microorganisms may influence MC activation via direct interaction or via secreted metabolites.…”

Section: Microbiota Regulating Cellular Players In Innate and Adaptivmentioning

confidence: 99%

AllergoOncology: Microbiota in allergy and cancer—A European Academy for Allergy and Clinical Immunology position paper

Untersmayr

Bax

Bergmann³

et al. 2019

Allergy

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The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti‐ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune‐related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

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“…However, it has become clear that they also play important roles in both innate and adaptive immune responses. MCs possess a variety of surface receptors, including Toll-like and other microbe-associated pattern recognition receptors, and are activated by inflammatory mediators, IgE, IgG, light chains, complement fragments, proteases, hormones, neuropeptides, and microbial products [2, 3]. Following activation, they produce a plethora of pro-inflammatory mediators and participate in inflammatory reactions in many organs [2].…”

Section: Introductionmentioning

confidence: 99%

“…The idea that the relationship between immunity and microbes is purely adversarial has been supplanted by an appreciation that the immune system has not only evolved to protect against pathogens, but also promotes and encourages a healthy microbiota. Under this paradigm, the role of MCs on the frontline of defense against pathogens suggests that they may also play an important role in fostering the host-microbiome relationship [3]. …”

Section: Introductionmentioning

confidence: 99%