Oral Administration of <i>Lactobacillus</i> Induces Cardioprotection

Oxman, Tatyana; Shapira, Michal; Klein, Rodica; Avazov, Natalie; Rabinowitz, Babeth

doi:10.1089/107555301750463224

Cited by 26 publications

(11 citation statements)

References 21 publications

(24 reference statements)

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“…There is a preliminary evidence that the use of probiotic Lactobacilli and its metabolic byproducts potentially confer benefits to the heart, including prevention and therapy of various ischemic heart syndromes [126] and reduction of serum cholesterol [127]. When L. plantarum 299v was supplemented to the diet of smokers, the serum levels of leptin and fibrinogen and LDL-cholesterol, the risk factors for cardiovascular disease, were also reduced [128].…”

Section: Future Emerging Areas For Probiotic Researchmentioning

confidence: 99%

Probiotics, Prebiotics, and Synbiotics: Gut and Beyond

Vyas

Ranganathan

2012

Gastroenterology Research and Practice

192

130

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The human intestinal tract has been colonized by thousands of species of bacteria during the coevolution of man and microbes. Gut-borne microbes outnumber the total number of body tissue cells by a factor of ten. Recent metagenomic analysis of the human gut microbiota has revealed the presence of some 3.3 million genes, as compared to the mere 23 thousand genes present in the cells of the tissues in the entire human body. Evidence for various beneficial roles of the intestinal microbiota in human health and disease is expanding rapidly. Perturbation of the intestinal microbiota may lead to chronic diseases such as autoimmune diseases, colon cancers, gastric ulcers, cardiovascular disease, functional bowel diseases, and obesity. Restoration of the gut microbiota may be difficult to accomplish, but the use of probiotics has led to promising results in a large number of well-designed (clinical) studies. Microbiomics has spurred a dramatic increase in scientific, industrial, and public interest in probiotics and prebiotics as possible agents for gut microbiota management and control. Genomics and bioinformatics tools may allow us to establish mechanistic relationships among gut microbiota, health status, and the effects of drugs in the individual. This will hopefully provide perspectives for personalized gut microbiota management.

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Section: Future Emerging Areas For Probiotic Researchmentioning

confidence: 99%

Probiotics, Prebiotics, and Synbiotics: Gut and Beyond

Vyas

Ranganathan

2012

Gastroenterology Research and Practice

192

130

View full text Add to dashboard Cite

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“…In addition, the use of probiotics may confer cardioprotective effects, including the prevention and attenuation of ischemic heart disease and the reduction of serum cholesterol [80].…”

mentioning

confidence: 99%

Role of Altered Intestinal Microbiota in Systemic Inflammation and Cardiovascular Disease in Chronic Kidney Disease

et al. 2014

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The normal intestinal microbiota plays a major role in the maintenance of health and disease prevention. In fact, the alteration of the intestinal microbiota has been shown to contribute to the pathogenesis of several pathological conditions, including obesity and insulin resistance, among others. Recent studies have revealed profound alterations of the gut microbial flora in patients and animals with chronic kidney disease (CKD). Alterations in the composition of the microbiome in CKD may contribute to the systemic inflammation and accumulation of gut-derived uremic toxins, which play a central role in the pathogenesis of accelerated cardiovascular disease and numerous other CKD-associated complications. This review is intended to provide a concise description of the potential role of the CKD-associated changes in the gut microbiome and its potential role the pathogenesis of inflammation and uremic toxicity. In addition, the potential efficacy of pre- and pro-biotics in the restoration of the microbiome is briefly described.

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“…La administración de L. helveticus y S. cerevisiae parece reducir la presión arterial sistólica y diastólica. En consecuencia, el consumo regular de probióticos y prebióticos puede proporcionar un modesto efecto profiláctico contra la enfermedad cardíaca 7,101 .…”

Section: Enfermedades Metabólico-nutricionales Protección Cardiovascuunclassified