Oral administration of fluoride in pregnant women, and the relation between concentration in maternal plasma and in amniotic fluid

Brambilla, Eugenio; G, Belluomo; Malerba, A.; Buscaglia, M; Strohmenger, L

doi:10.1016/0003-9969(94)90084-1

Cited by 14 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…F is now known to pass through the placenta [ 110 , 111 ], although one study suggests that the placenta may be a more effective barrier at increased maternal F exposure [ 112 ]. F has been found in the placenta [ 110 ], cord blood [ 109 , 112 , 113 ], and amniotic fluid [ 109 , [113] , [114] , [115] ].…”

Section: Fluoride In Pregnancy and Child Neurodevelopmentmentioning

confidence: 99%

A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

Griebel-Thompson¹,

Sands²,

Chollet‐Hinton³

et al. 2023

Advances in Nutrition

View full text Add to dashboard Cite

Section: Fluoride In Pregnancy and Child Neurodevelopmentmentioning

confidence: 99%

A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

Griebel-Thompson¹,

Sands²,

Chollet‐Hinton³

et al. 2023

Advances in Nutrition

View full text Add to dashboard Cite

“…There is placental passage of fluoride from the maternal to the fetal circulation. This conclusion comes both from studies on the relationship between maternal plasma (or serum) and cord blood [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51], and studies on the metabolism of obstetrical anesthetics containing fluoride [52][53][54][55]. In the latter studies, there was evidence of fluoride in neonatal urine in levels that were proportional to the obstetrical anesthetic's concentration, which provided further evidence on the transfer of fluoride from mother to fetus.…”

Section: Placental Passage Of Fluoridementioning

confidence: 99%

“…Higher concentrations of fluoride are found in the placenta, maternal plasma (or serum) and cord blood from women living in fluoridated areas [34][35][36]. In women who were supplemented with fluoride tablets at some point during their pregnancy, the concentration of fluoride in maternal plasma and cord blood increased as a function of the supplement's concentration [45,48].…”

Section: Placental Passage Of Fluoridementioning

confidence: 99%

Fluoride Metabolism in Pregnant Women: A Narrative Review of the Literature

Castiblanco

Mier

2022

Metabolites

View full text Add to dashboard Cite

Epidemiological studies use biomarkers of fluoride exposure in pregnant women as surrogate measures of fetal fluoride exposure; however, there is little understanding of how pregnancy affects fluoride metabolism and its biomarkers. This narrative review summarizes the changes of pregnancy that have the potential to impact fluoride’s absorption, distribution and excretion, and highlights the limited body of evidence on the topic. The physiologic systems that experience pregnancy-associated changes relevant to fluoride’s metabolism are the cardiovascular, renal, metabolic and gastrointestinal, as well bone and calcium metabolism and the body’s acid-base balance. The available evidence indicates that fluoride is found in the maternal plasma and urine, placenta, amniotic fluid and fetus. Although plasma and urinary fluoride vary across gestation, there is insufficient quality evidence to determine the direction or extent of such variation. Furthermore, there is no doubt that fluoride from maternal blood crosses the placenta and is absorbed and excreted by the fetus; however, the biological mechanisms behind this placental passage are unknown. Research on maternal and prenatal biomarkers of fluoride exposure would benefit from studies on how pregnancy-associated changes affect the metabolism of fluoride across gestation, the mechanisms for the intestinal absorption of fluoride in pregnant women, and the placental passage of fluoride.

show abstract

“…It is well known that the blood placental barrier can protect the fetus from maternal hazardous substances. However, the placenta is not considered to be a barrier to fluoride and the transport of fluoride through the placenta changes as pregnancy progresses [17,18]. It has been reported that the ingestion of fluoride during pregnancy results in elevated levels of fluoride in maternal blood, amniotic fluid, and fetal blood [19,20].…”

Section: Development Of Organismmentioning

confidence: 99%

Toxicity effects and action mechanism of fluoride

Chai

Jiang

Yanfei

et al. 2011

2011 International Symposium on Water Resource and Environmental Protection

View full text Add to dashboard Cite

The toxicity and action mechanism of fluoride were reviewed in this paper. Fluoride disturbs the processes of individual growth and development at organism, organ and cell levels. Fluoride may cause malformation of embryo in individual development of animals. In addition, fluoride also possesses the toxicity effect on digestive system, skeletal system and nervous system. Finally, fluoride disturbs the activity of enzymes, and then induces the oxidative stress and cell apoptosis.

show abstract

Oral administration of fluoride in pregnant women, and the relation between concentration in maternal plasma and in amniotic fluid

Cited by 14 publications

References 21 publications

A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

A Scoping Review of Iodine and Fluoride in Pregnancy in Relation to Maternal Thyroid Function and Offspring Neurodevelopment

Fluoride Metabolism in Pregnant Women: A Narrative Review of the Literature

Toxicity effects and action mechanism of fluoride

Contact Info

Product

Resources

About