Oral adenoid squamous cell carcinoma: A report of three cases and review of the literature

Jones, A. Vallance; Freedman, Paul D.; Kerpel, Stanley M.

doi:10.1016/s0278-2391(10)80269-1

Cited by 44 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most common site of ASCC is sun-exposed skin [9]. Mucosal ASCC is rare but has been reported in multiple locations in the aerodigestive tract particularly the oral cavity including the buccal mucosa, tongue, gingiva, floor of mouth and larynx [6,14,15]. Rare cases of ASCC in the cecal mucosa [16] and breast parenchyma [8,17] have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Jiang

Fowler

2012

Head and Neck Pathol

View full text Add to dashboard Cite

Acantholytic squamous cell carcinoma is a rare variant of squamous cell carcinoma in the mucosa of upper aerodigestive tract. Histomorphologically, acantholytic squamous cell carcinoma may lose the typical features of conventional squamous cell carcinoma and mimic other epithelial or mesenchymal malignancies due to advanced acantholysis and dyskeratosis. Because of its rarity, information of prognosis, pathologic features and immunohistochemical profiles is limited. We have studied clinicopathologic features and immunohistochemical profiles of four acantholytic squamous cell carcinoma cases arising from upper aerodigestive tract. Clinical results indicate an aggressive biologic behavior. Morphologically, all tumors revealed significant acantholysis with separation of tumor cells and intratumoral spaces. The tumor cells were highly pleomorphic and growth patterns were variable. In immunohistochemical studies, all tumor cells revealed positive reactions for AE1/AE3 and p63 supporting a squamous epithelial origin. In contrast to conventional aerodigestive squamous cell carcinoma, acantholytic squamous cell carcinoma showed significant reductions of cytokeratin19, E-cadherin and concomitant up-regulation of vimentin expression. Both morphologic features and immunohistochemical profiles indicate that acantholytic squamous cell carcinoma has acquired an epithelial mesenchymal transition phenotype. However, in contrast to other solid malignant tumors, the epithelial mesenchymal transition phenotype change in acantholytic squamous cell carcinoma is not limited to the invasive front of the peripheral tumor but, rather, diffusely involves entire neoplastic lesion. In addition, because cytokeratin 19 staining is attenuated, this would be an insensitive marker for following up and/or in detecting disseminated tumor cells in cases of acantholytic squamous cell carcinoma in upper aerodigestive tract.

show abstract

Section: Discussionmentioning

confidence: 99%

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Jiang

Fowler

2012

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…Acantholytic SCC of the UADT is an uncommon variant that retains squamous differentiation but shows a high degree of acantholysis, which thus imparts the tumors with pseudoglandular or pseudovascular spaces. [70][71][72][73][74][75][76][77][78] Similar to other subtypes of SCC, acantholytic SCC occurs in older men. It is most commonly seen in sun-exposed areas, such as at the vermillion border of the lip.…”

Section: Scc Variants Defined By Histologymentioning

confidence: 99%

Cytology of head and neck squamous cell carcinoma variants

Chute

Stelow

2009

Diagnostic Cytopathology

View full text Add to dashboard Cite

The most common diagnosis rendered with head and neck fine needle aspiration (FNA) biopsy is metastatic squamous cell carcinoma (SCC). While most cases of metastatic SCC pose little diagnostic difficulty, the diagnosis of metastatic histologic variants of SCC, often coupled with less common etiologies, can be more problematic. This manuscript reviews the clinicopathologic features of the histologic variants of upper aerodigestive tract SCC (verrucous, papillary, spindle cell, undifferentiated, acantholytic, and basaloid) and uncommon etiologies of head and neck SCC (human papillomavirus, Epstein-Barr Virus, and NUT midline carcinomas). Particular attention is paid to the cytologic features of these lesions. Differential diagnoses and the use of ancillary testing are discussed.

show abstract

“…[9] Baş boyun yerleşimli akantolitik SHK sıklıkla güneş gören cilt ve dudakta görülmesine rağ-men; nadir olarak oral kavite, nazofarenks, dil ve larenkste de görülebilmektedir. [9][10][11][12][13][14][15] Akantolitik SHK'lerde en iyi prognoz Jones ve ark. [11] tarafın-dan dudak yerleşimli tümörlerde bildirilmiştir.…”

Section: şEkil 4 Yaygın Metastazların Görüldüğü Pozitron Emisyon Tomunclassified

“…[9][10][11][12][13][14][15] Akantolitik SHK'lerde en iyi prognoz Jones ve ark. [11] tarafın-dan dudak yerleşimli tümörlerde bildirilmiştir. Bunun aksine, cilt yerleşimli akantolitik SHK'li olgularda erken metastaz ve hastalığın fatal seyrettiği gözlenmiştir.…”

Section: şEkil 4 Yaygın Metastazların Görüldüğü Pozitron Emisyon Tomunclassified

Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma

D²,

Batur³

et al. 2016

Kulak Burun Bogaz Ihtis Derg

View full text Add to dashboard Cite

ÖZAkantolitik skuamöz hücreli karsinom, skuamöz hücreli karsinomun nadir bir varyantıdır. Akantolitik skuamöz hücreli karsinom, güneş gören ciltte ve dudakta oluşabilmektedir. Solunum ve sindirim yolunda oldukça nadir görülmekle birlikte, daha agresif seyretmektedir. Ayrıca, skuamöz hücreli baş boyun kanserlerinde uzak metastaz oranı düşük olmakla birlikte, en sık akciğere metastaz görülür. Larenks bölgesinden yumuşak dokuya, cilde ve böbrek üstü bezlere metastaz çok nadir görülmektedir. Bu yazıda, akantolitik skuamöz hücreli larenks kanseri tanısıyla ameliyat sonrası radyoterapi uygulanan ve erken dönemde yumuşak doku ve böbrek üstü bezlere metastaz gelişen 58 yaşında bir kadın olgu sunuldu.Anahtar Sözcükler: Akantolitik skuamöz hücreli kanser; larenks kanseri; yumuşak doku metastazı. ABSTRACTAcantholytic squamous cell carcinoma is an uncommon variant of squamous cell carcinoma. Acantholytic squamous cell carcinoma occurs in the sun-exposed areas of the skin and lip. It is rarely observed in the respiratory and digestive tract and may present more aggressively. The incidence of distant metastases of squamous cell head and neck cancers is low and the lungs are the most common metastatic sites. Metastasis to the soft tissue, skin, and adrenal glands from the laryngeal region is very uncommon. In this article, we report a 58-year-old female case who underwent postoperative radiation therapy with the diagnosis of acantholytic squamous cell carcinoma of the larynx and developed metastasis to the soft tissue and adrenal gland at the early period.

show abstract

Oral adenoid squamous cell carcinoma: A report of three cases and review of the literature

Cited by 44 publications

References 14 publications

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Cytology of head and neck squamous cell carcinoma variants

Acantholytic squamous cell carcinoma of larynx as an uncommon variant of squamous cell carcinoma

Contact Info

Product

Resources

About