Cytology of head and neck squamous cell carcinoma variants

Chute, Deborah J.; Stelow, Edward B.

doi:10.1002/dc.21134

Cited by 32 publications

(39 citation statements)

References 112 publications

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“…Mean age was 44.8years this is much below when we compared from western data of about 60 to 70years. But Indian study by Viswanathan S et al 2,3 showed mean age of presentation was 53 and 58.18years respectively comparable to present study. Predisposing factors are smoking, alcohol consumption, previous radiation exposure.…”

Section: Discussion and Review Of Literaturesupporting

confidence: 83%

“…One patient (20%) presented with nodal metastasis. The largest landmark study by Bataskis et al, 3 showed nodal metastasis of 24%. Carcinosarcoma is treated same as squamous cell carcinoma of head and neck there is no different established guidelines for this relatively rare entity.…”

Section: Discussion and Review Of Literaturementioning

confidence: 97%

“…1 It consists of epithelial and mesenchymal components hence diagnosis is challenging and complex, Monoclonal hypothesis has been proved by many studies that both components have the same monoclonal origin with transformation and dedifferentiation of epithelial cell to spindle cells supported by immunohistochemistry. 2,3 It usually occurs in males during 6 th and 7 th decades of life. Similar to other studies, 4,5 male predominance was reported in this study with M:F ratio 4:1.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…1 These tumors are biphasic and it have been proved by many studies that it evolves from conventional squamous carcinoma with dedifferentiation associated with sarcomatoid transformation. 2,3 Most commonly it arises from larynx, nasal cavity, hypopharynx, esophagus, trachea, oral mucosa. It has a male predominance with mean age of presentation in sixth decades of life with history of smoking, alcohol abuse, and radiation exposure.…”

Section: Introductionmentioning

confidence: 99%

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Carcinosarcoma of Head and Neck; Clinicopathological Characteristics, Treatment and Outcomes of Unique Neoplasm

Singh

Sharma

2017

IJRRT

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Background: Carcinosarcoma of the Head and neck is rare neoplasm with incidence of <1%. This is biphasic tumor with epithelial and mesenchymal components. Rarity of this neoplasm is major obstacle to establish proper guidelines. Only few case series and reports are available. Aim:The aim of this study was to evaluate clinicopathological characteristics, treatment and its outcome to contribute in part to the better understanding and awareness of this rare malignancy. Material and Methods:Retrospectively data of histological proven carcinosarcoma of head and neck from 2013 to 2015 was retrieved and evaluated for various parameters and also compared with both Indian and western data. Results:Total of 5 patients of carcinosarcoma were registered within selected timeframe. The mean age of 44.8years ranged from 27years to 68years. Male predominance was reported with M:F ratio 4:1.Oral cavity is most common site of tumor followed by oropharynx .Surgery is primary modality of treatment followed by adjuvant radiotherapy as per indication .Shortest follow up was 11month and longest was 31months. Only One patient was presented with recurrence. Conclusion:The diagnosis of carcinosarcoma is challenging so histopathology along with immunohistochemistry is needed for appropriate diagnosis. Oral cavity seems to be the most common site with younger age group in present study which is supported by other Indian studies. Future studies are needed to define the geographical variation with clinicopathological character as well as treatment protocol for this relatively rare entity.

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Section: Discussion and Review Of Literaturesupporting

confidence: 83%

Section: Discussion and Review Of Literaturementioning

confidence: 97%

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Carcinosarcoma of Head and Neck; Clinicopathological Characteristics, Treatment and Outcomes of Unique Neoplasm

Singh

Sharma

2017

IJRRT

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“…Except in the lip (perhaps due to early detection and treatment), the head and neck mucosal ASCCs reported were associated with poor prognoses. Histomorphologically, ASCC may lose the typical features of SCC and mimic other epithelial or mesenchymal malignancies because of advanced acantholysis and dyskeratosis [5,11,12]. Because of its rarity, most of the previous studies have been case reposts and information concerning the immunohistochemical features of ASCC is limited.…”

Section: Introductionmentioning

confidence: 99%

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Jiang

Fowler

2012

Head and Neck Pathol

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Acantholytic squamous cell carcinoma is a rare variant of squamous cell carcinoma in the mucosa of upper aerodigestive tract. Histomorphologically, acantholytic squamous cell carcinoma may lose the typical features of conventional squamous cell carcinoma and mimic other epithelial or mesenchymal malignancies due to advanced acantholysis and dyskeratosis. Because of its rarity, information of prognosis, pathologic features and immunohistochemical profiles is limited. We have studied clinicopathologic features and immunohistochemical profiles of four acantholytic squamous cell carcinoma cases arising from upper aerodigestive tract. Clinical results indicate an aggressive biologic behavior. Morphologically, all tumors revealed significant acantholysis with separation of tumor cells and intratumoral spaces. The tumor cells were highly pleomorphic and growth patterns were variable. In immunohistochemical studies, all tumor cells revealed positive reactions for AE1/AE3 and p63 supporting a squamous epithelial origin. In contrast to conventional aerodigestive squamous cell carcinoma, acantholytic squamous cell carcinoma showed significant reductions of cytokeratin19, E-cadherin and concomitant up-regulation of vimentin expression. Both morphologic features and immunohistochemical profiles indicate that acantholytic squamous cell carcinoma has acquired an epithelial mesenchymal transition phenotype. However, in contrast to other solid malignant tumors, the epithelial mesenchymal transition phenotype change in acantholytic squamous cell carcinoma is not limited to the invasive front of the peripheral tumor but, rather, diffusely involves entire neoplastic lesion. In addition, because cytokeratin 19 staining is attenuated, this would be an insensitive marker for following up and/or in detecting disseminated tumor cells in cases of acantholytic squamous cell carcinoma in upper aerodigestive tract.

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Does the 3‐gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?

Shibru

Hwang

Khanafshar

et al. 2008

Cancer

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BACKGROUND.A 3‐gene (PCSK2, PLAB, CCND2) assay has been reported to have high accuracy for distinguishing benign from malignant thyroid tumors that are often indeterminate on fine–needle aspiration (FNA) biopsy. The aim of the current study was to determine the diagnostic accuracy of the 3‐gene assay in thyroid tissue and in FNA biopsy for distinguishing benign from malignant thyroid neoplasms.METHODS.The messenger ribonucleic acid (mRNA) expression level of 3 genes (PCSK2, PLAB, CCND2) was analyzed by real‐time quantitative reverse transcriptase–polymerase chain reaction in 261 frozen thyroid tissue samples (138 benign and 123 malignant), and prospectively, in 144 clinical thyroid FNA samples. To determine the diagnostic accuracy of the 3‐gene assay, the area under the curve (AUC) of the receiver operating characteristic curve for each gene individually and in combination was determined.RESULTS.PCSK2 and CCND2 mRNA expression levels were found to be significantly different between benign and malignant thyroid tissue samples (P < .0001 and P = .0007, respectively), but PLAB mRNA expression level was not (P = .099). In the thyroid tissue samples, the AUC was 0.67 for PCSK2 and 0.62 for CCND2. In the thyroid FNA samples, PCSK2 and CCND2 were significantly differentially expressed between benign and malignant samples (P = .039 and P = .023, respectively). The AUC was 0.59 for PCSK2 and 0.61 for CCND2.CONCLUSIONS.Although PCSK2 and CCND2 were significantly differentially expressed between benign and malignant thyroid tumors both in tissue and in FNA samples, the diagnostic accuracy of the 3‐gene assay was low. These findings demonstrate that it is essential for studies to validate the diagnostic accuracy and clinical utility of emerging candidate diagnostic thyroid cancer markers if they are to be translated into clinically useful markers for making patient care decisions. Cancer 2008. © 2008 American Cancer Society.

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Cytology of head and neck squamous cell carcinoma variants

Cited by 32 publications

References 112 publications

Carcinosarcoma of Head and Neck; Clinicopathological Characteristics, Treatment and Outcomes of Unique Neoplasm

Carcinosarcoma of Head and Neck; Clinicopathological Characteristics, Treatment and Outcomes of Unique Neoplasm

Acantholytic Squamous Cell Carcinoma in Upper Aerodigestive Tract: Histopathology, Immunohistochemical Profile and Epithelial Mesenchymal Transition Phenotype Change

Does the 3‐gene diagnostic assay accurately distinguish benign from malignant thyroid neoplasms?

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