Optomechanical design of multiscale gigapixel digital camera

Son, Hui S.; Johnson, Adam R.; Stack, Ronald A.; Shaw, Jeffrey M.; McLaughlin, Paul O.; Marks, Daniel L.; Brady, David J.; Kim, Jungsang

doi:10.1364/ao.52.001541

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Cited by 16 publications

(1 citation statement)

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“…Independent of the employed digital sensor, most objective lenses are limited to a SBP of approximately 10–50 megapixels. Several recent camera architectures aim at overcoming this physical limit via jointly designed optics and digital processing [2, 3], but few have attempted a solution within a microscope setup.…”

Section: Introductionmentioning

confidence: 99%

Digital pathology with Fourier ptychography

Horstmeyer¹,

Ou²,

Zheng³

et al. 2015

Computerized Medical Imaging and Graphics

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Fourier ptychographic microscopy (FPM) is a recently introduced method of acquiring high-resolution, wide field of view (FOV) giga-pixel histology images. The FPM procedure first acquires a sequence of low-resolution images of a sample under variable-angle illumination. It then combines these images using a novel phase retrieval algorithm to improve the employed microscope’s resolution beyond its conventional limit. Here, we first describe how FPM’s resolution improvement can enhance wide FOV histology imaging. Second, we show that FPM also records a thin sample’s optical phase, which can help pathologists digitally extract as much information as possible from a given histology slide.

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Section: Introductionmentioning

confidence: 99%