Optofluidics in Microstructured Optical Fibers

Shao, Liyang; Liu, Zhengyong; Hu, Jie; Gunawardena, Dinusha Serandi; Tam, Hwa Yaw

doi:10.3390/mi9040145

Cited by 30 publications

(22 citation statements)

References 98 publications

(123 reference statements)

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“…Several optical fiber sensors have been reported for microorganism monitoring [9]. These sensors mainly rely on a label-free sensing mechanism, where changes in optical properties or the thickness of the growing biological films are monitored in the vicinity of the sensor surface [10][11][12][13]. For these devices, the influence of the optical properties of the applied buffers or CCM is important to identify sensitivity and the limit of detection, but it is usually neglected.…”

Section: Introductionmentioning

confidence: 99%

Optical Properties of Buffers and Cell Culture Media for Optofluidic and Sensing Applications

et al. 2019

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Interactions between light and various cells in cultures, such as bacteria or mammalian cells, are widely applied for optical sensors and optofluidic systems. These microorganisms need to be kept in proper aqueous media, referred to as buffers or cell culture media, that are required, respectively, for stable storage or delivering biochemical nutrients for their growth. When experiments or numerical analyses on optical devices are performed, the properties of these media are usually considered to be similar to those of pure water, with negligible influence of biochemical compounds on the medium’s optical properties. In this work, we investigated the transmission, material dispersion, and scattering properties of selected and widely used buffers and cell culture media. We show that the optical properties of these media may significantly vary from those of water. Well-defined properties of buffers and cell culture media are essential for proper design of various optical sensing or future optofluidic systems dealing with biological structures.

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Section: Introductionmentioning

confidence: 99%

Optical Properties of Buffers and Cell Culture Media for Optofluidic and Sensing Applications

et al. 2019

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“…Next implementation level of optical fibers in the miniaturization process of fluorescence sensing is represented by the microstructured optical fiber (MOF) or photonic crystal fiber (PCF). The field of optofluidics in microstructured optical fibers was recently reviewed in Shao (2018) and Ertman et al (2017). It gained high interest due to its capability of simplifying optical fiber sensors and improving the level of integration.…”

Section: Optical-fiber-based Designsmentioning

confidence: 99%

Miniaturization of fluorescence sensing in optofluidic devices

Măriuța

Colin

Barrot-Lattes

et al. 2020

Microfluid Nanofluid

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Successful development of a micro-total-analysis system (µTAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.

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“…They demonstrated the relevance of the proposed sensor type in real-time or in situ detection of zinc, aluminum, and lithium ions; however, the approach is versatile, with the potential usage for the detection of other ions as well. The recent development and applications of MOFs in the microfluidic field was reviewed by Shao L. et al [73], Tian F. et al [74], Eggleton B. J. et al [75], and Pissadakis S. and Selleri S. [76].…”

Section: Microstructured Optical Fibers Functionalized With Plasmonicmentioning

confidence: 99%

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

et al. 2020

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Microstructured optical fiber-based sensors (MOF) have been widely developed finding numerous applications in various fields of photonics, biotechnology, and medicine. High sensitivity to the refractive index variation, arising from the strong interaction between a guided mode and an analyte in the test, makes MOF-based sensors ideal candidates for chemical and biochemical analysis of solutions with small volume and low concentration. Here, we review the modern techniques used for the modification of the fiber’s structure, which leads to an enhanced detection sensitivity, as well as the surface functionalization processes used for selective adsorption of target molecules. Novel functionalized MOF-based devices possessing these unique properties, emphasize the potential applications for fiber optics in the field of modern biophotonics, such as remote sensing, thermography, refractometric measurements of biological liquids, detection of cancer proteins, and concentration analysis. In this work, we discuss the approaches used for the functionalization of MOFs, with a focus on potential applications of the produced structures.

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Optofluidics in Microstructured Optical Fibers

Cited by 30 publications

References 98 publications

Optical Properties of Buffers and Cell Culture Media for Optofluidic and Sensing Applications

Optical Properties of Buffers and Cell Culture Media for Optofluidic and Sensing Applications

Miniaturization of fluorescence sensing in optofluidic devices

Functionalized Microstructured Optical Fibers: Materials, Methods, Applications

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