Options for Modeling and Simulations Used in Mechanical Circulatory Support Development

Horvath, David J.; Fukamachi, Kiyotaka; Karimov, Jamshid H.

doi:10.1007/978-3-030-47809-4_27

Cited by 1 publication

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References 17 publications

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“…The VML, coded in software MATLAB® (MathWorks, Inc., Natick, MA), simulates the hemodynamics of the human cardiovascular system by mathematically calculated parameters. 15,16 The simulation was created from several inputs, such as systolic and diastolic ventricular compliance, beat rate, pump performance, and blood volume, and it simulates the systemic and pulmonary circulation along with four cardiac chambers and valves using equations described in. 17,18 By the way of introduction to the VML, a schematic of the electrical analog circulatory system model with LVAD and RVAD is presented in Figure 1.…”

Section: Virtual Mock Loopmentioning

confidence: 99%

Evaluation of centrifugal blood pump performances for biventricular support in the virtual simulation model

Kuroda

Miyamoto

Horvath³

et al. 2022

Artificial Organs

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Background Despite the advances in the left ventricular assist device (LVAD), there are still situations that require a biventricular assist device (BVAD) system. The purpose of this study was to explore and compare the system performance interactions with the HeartMate3 (HM3) and HeartWare (HVAD) in a BVAD configuration using the virtual mock loop (VML) simulation tool. Methods The VML simulation tool is an in silico implementation of a lumped parameter model of the cardiovascular system with mechanical circulatory support. Patients with ejection fractions of 60%, 20%, and 15% were simulated in VML, and the HVAD and HM3 in a BVAD with ventricular cannulation were applied to simulated conditions. Pump speeds that restored baseline normal hemodynamics were determined. To determine the optimal speeds for BVAD, the left and right arterial pressures (LAP, RAP) were plotted. Results In the HVAD, LAP and RAP are balanced at 11 mm Hg with LVAD 3500 rpm, right ventricular assist device (RVAD) 2200 rpm; at 13 mm Hg with LVAD 3000 rpm, RVAD 1700 rpm; and at 14 mm Hg with LVAD 2500 rpm, RVAD 1300 rpm. For the HM3, at 8 mm Hg with LVAD 7000 rpm, RVAD 5000 rpm; at 9 mm Hg with LVAD 6000 rpm, RVAD 4300 rpm; and at 9.5 mm Hg with LVAD 5000 rpm, RVAD 3500 rpm. Conclusion The RVAD/LVAD speed ratios required for atrial balance were approximately 0.6 for the HVAD and 0.7 for the HM3. However, the HVAD required RVAD speeds below its range of operation.

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