Optimizing experimental conditions for minimum production cost in preparative chromatography

Abstract

In trod uc t ionThe optimization of the experimental conditions in preparative liquid chromatography is a topic of serious current concern (Colin, 1993a). This is due to the growing interest of the pharmaceutical industry for this new separation method which permits the purification of significant amounts of drug intermediates, peptides, or proteins by eliminating closely related, but unwanted, compounds. While at the research and development level the actual preparation cost is often a minor fraction of the total cost of the project, in production new perspectives are introduced. This requires that the optimization of the experimental conditions should achieve the lowest possible production cost. This cost includes contributions of capital (such as chromatograph, pumps, tubings and valvings, and building), operating (solvents, stationary phase, raw material lost, and energy), and labor. It is difficult, however, to account for all the cost contributions in the design of a new separation method, especially with a new process like liquid chromatography. Accounting procedures vary widely from company to company, if not within divisions of a large company. For example, overhead may constitute a large fraction of the total costs, and it is calculated following rules specific to each com-

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Optimization and comparison of different modes of preparative chromatography

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Comparison of Various Process Engineering Concepts of Preparative Chromatography

“…In evaluating the classical elution process in the literature, frequently the recovery yield REC and the production rate PR (e.g., [20]) or a combination of these two [21] are applied as objective functions. Further, it might be important to consider the specific eluent consumption, EC.…”