Optimized polymer coating for magnesium alloy-based bioresorbable scaffolds for long-lasting drug release and corrosion resistance

Xu, Wei; Yagoshi, Kai; Koga, Yoshiko; Sasaki, Makoto; Niidome, Takuro

doi:10.1016/j.colsurfb.2017.12.032

Cited by 43 publications

(35 citation statements)

References 33 publications

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“…An increase in the roughness of the specimens was observed as a result of adding different amounts of baghdadite powder. The presence of chloride ions in the SBF solution damaged the oxide and hydroxide layers on the surface of the anodized AZ91 alloy and subsequently led to the formation of cavities on the surface, thus resulting in the corrosion of the substrate [11]. As a result, the degradability resistance of the magnesium-based alloy decreased in the SBF medium, thus reducing the total resistance of the implant [36].…”

Section: Resultsmentioning

confidence: 99%

“…However, its high corrosion rate causes the formation of cavities and porosities after implantation, which can negatively affect its mechanical and biological properties [9,10]. Many studies have been conducted on controlling the degradation rate of magnesium and its alloys for medical applications [11,12]. A new approach to increase the life of metal implants is to apply nanostructured coatings on their surfaces.…”

Section: Introductionmentioning

confidence: 99%

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Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid

et al. 2020

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Polymer-ceramic composite coatings on magnesium-based alloys have attracted lots of attention in recent years, to control the speed of degradability and to enhance bioactivity and biocompatibility. In this study, to decrease the corrosion rate in a simulated body fluid (SBF) solution for long periods, to control degradability, and to enhance bioactivity, polycaprolactone-chitosan composite coatings with different percentages of baghdadite (0 wt.%, 3 wt.%, and 5 wt.%) were applied to an anodized AZ91 alloy. According to the results of the immersion test of the composite coating containing 3 wt.% baghdadite in a phosphate buffer solution (PBS), the corrosion rate decreased from 0.45 (for the AZ91 sample) to 0.11 mg/cm 2 ·h after seven days of immersion. To evaluate the apatite formation capability of specimens, samples were immersed in an SBF solution. The results showed that the samples were bioactive as apatite layers formed on the surface of specimens. The composite coating containing 3 wt.% baghdadite showed the highest apatite-formation capability, with a controlled release of ions, and the lowest corrosion rate in the SBF.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid

et al. 2020

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Section: Introductionmentioning

confidence: 99%

“…A popular approach to provide such temporary and biocompatible protection mechanism is to coat the Mg surface with a biocompatible polymer such as polycaprolactone (PCL), polylactic acid (PLA) or poly(vinyl acetate) (PVAc). [16][17][18][19] In order to be effective such polymeric coatings require chemical compatibility with surrounding tissue but should eventually disintegrate leaving the intact cellular structure in place. While the polymeric material needs to retain integrity for a suitable period of time, it must eventually break down into components that can be eliminated from the body without inducing toxic effects.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Conducting Polymer Coating to Mitigate Early Stage Degradation of Magnesium in Simulated Biological Fluid: An Electrochemical Mechanistic Study

et al. 2019

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The application of a biodegradable conducting polymer coating based on a polythiophene composite (PTC) to mitigate degradation of magnesium in an in vitro environment is reported. The rationale behind the study is to advance a bioactive coating to control the rapid early stage degradation of the magnesium and prevent inflammatory reactions and physiological complications, while, in the long term, the coating degrades, followed by the full degradation of the magnesium implant. The conducting polymer in this study is deposited on a bioabsorbable medical grade magnesium alloy, AZNd, through layer‐by‐layer deposition, and the degradation behavior in simulated biological fluid is studied electrochemically. The possibility of a synergistic effect by combining praseodymium conversion coating together with the conducting polymer coating in protecting magnesium is also examined. Results show that the highest level of corrosion mitigation is afforded by the combination of praseodymium conversion and the conducting polymer coating layers. Electrochemical models are advanced to explain the electroactivity of the conducting polymer across the film as well as at the interface with electrolyte and substrate. Based on the physical and electrochemical evidence, the barrier effect is proposed as the main protection mechanism.

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“…A good range of biodegradable and biocompatible materials have been tried out to fulfil this task, showing there is no unique solution to this question. Up to date, DES have been made of different polymers, but some of the most used ones are poly(lactic acid) and poly(lactic-co-glycolic acid) [27][28][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Controlled Release on Cardiovascular Stents Using Plasma-Enhanced Adhesion of Biodegradable Nanoparticles

2019

Med One

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One of the most common solutions to treat ischemic heart disease nowadays is the implantation of drug eluting stents. Currently, new strategies are being developed to improve healing process, which includes pharmacological treatments or gene therapy. In this paper, we presented a proposal based on the use of poly(β-amino ester) (pBAE) nanoparticles.To enhance the release method, we used an approach based on attaching these nanoparticles on a polymeric coating. The process includes coating metallic cardiovascular stents with a thin and highly functionalized layer of pentafluorophenyl methacrylate (PFM) to which loaded nanoparticles are chemically bonded. Through this design, when a stent is expanded during its implantation, nanoparticles will stay attached to the polymer matrix. Nanocarriers will penetrate target adjacent cells, guaranteeing effective drug delivery. Results obtained show that this work opens a pathway for pharmacological and/or gene delivery systems based on the adhesion of pBAE nanoparticles prior to stent implantation. KEYWORDS: control release; cardiovascular stent; pentafluorophenyl methacrylate (PFM); gene delivery; poly(β-amino ester) (pBAE) ABBREVIATIONS CAD Coronary Artery Disease CDCP Centres for Disease Control and Prevention DES Drug eluting stents BMS Bare metal stent PBAE Poly(β-amino ester) MiRNA Micro RNA SiRNA Small interfering RNA RNAi Interfering RNA PFM Pentafluorophenyl methacrylate GFP Green fluorescent plasmid PGFP Green fluorescent protein vector SEM Scanning electron microscopy AFM Atomic force microscopy Open Access

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Optimized polymer coating for magnesium alloy-based bioresorbable scaffolds for long-lasting drug release and corrosion resistance

Cited by 43 publications

References 33 publications

Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid

Bioactivity Behavior Evaluation of PCL-Chitosan-Nanobaghdadite Coating on AZ91 Magnesium Alloy in Simulated Body Fluid

Biodegradable Conducting Polymer Coating to Mitigate Early Stage Degradation of Magnesium in Simulated Biological Fluid: An Electrochemical Mechanistic Study

Controlled Release on Cardiovascular Stents Using Plasma-Enhanced Adhesion of Biodegradable Nanoparticles

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