Optimization of triple quadrupole mass spectrometer for quantitation of trace degradants of pharmaceutical compounds

Jiao, Jim; Carella, Anthony J.; Steeno, Gregory S.; Darrington, Richard T.

doi:10.1016/s1387-3806(02)00593-6

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…The LLQ as defined elsewhere was ca. 40 ng/mL 23. The increase in des‐cladinose at 30°C as a function of time is shown in Figure 6.…”

Section: Resultsmentioning

confidence: 95%

“…Prior to LC/MS analysis, the mass spectrometer was tuned to obtain the maximal signal‐to‐noise ratio for the model macrolide. Statistic analysis determined that the tuning parameters impacting the signal‐to‐noise ratio of macrolides were cone, capillary, extractor, radio frequency (RF) lens voltages, and high mass resolution (HM Res1) 23. The optimal values of the instrument parameters were low extractor voltage (17 V), medium capillary voltage (3 kV), medium cone voltage (48 V), high RF lens voltage (0.9 V), and medium HM Res1 (2.5).…”

Section: Methodsmentioning

confidence: 99%

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Rapid and accurate prediction of degradant formation rates in pharmaceutical formulations using high-performance liquid chromatography-mass spectrometry

Darrington

Jiao

2004

Journal of Pharmaceutical Sciences

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“…The LLQ as defined elsewhere was ca. 40 ng/mL 23. The increase in des‐cladinose at 30°C as a function of time is shown in Figure 6.…”

Section: Resultsmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Rapid and accurate prediction of degradant formation rates in pharmaceutical formulations using high-performance liquid chromatography-mass spectrometry

Darrington

Jiao

2004

Journal of Pharmaceutical Sciences

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“…Quadrupole mass spectrometers 12 with cylindrical rods are commonly used and are very successful as mass filters because of their excellent performance and low cost. 13 In the last 40 years, the most important progress in QMS technology was in the field of manufacturing and application in new measuring methods, notably combining high resolution organic chromatography with QMS and using miniature QMS for gas analysis ͑RGA͒ at relative high pressure.…”

Section: -11mentioning

confidence: 99%

Study of a micro chamber quadrupole mass spectrometer

Wang

Zhang

Mao

et al. 2008

Journal of Vacuum Science &Amp; Technology A: Vacuum, Surfaces, and Films

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The design of a micro chamber quadrupole mass spectrometer ͑MCQMS͒ having a small total volume of only 20 cm 3 , including Faraday cup ion detector and ion source, is described. This MCQMS can resist a vacuum baking temperature of 400-500°C. The quadrupole elements with a hyperbolic surface are made of a ceramic material and coated with a thin metal layer. The quadrupole mass filter has a field radius of 3 mm and a length of 100 mm. Prototypes of this new MCQMS can detect a minimum partial pressure of 10 −8 Pa, have a peak width of ⌬M = 1 at 10% peak height from mass number 1 to 60, and show an excellent long-term stability. The new MCQMS is intended to be used in residual gas analyses of electron devices during a mutual pumping and baking process.

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“…In the same way, the ethnopharmacological information is disappearing too, and this is more pronounced in industrialized countries (Weldegerima 2009). Also, most of the active compounds in these species are usually found in low concentrations (Mulabagal and Tsay 2004), and to solve this problem several techniques have been developed (Jiao et al 2002, Van Ruth et al 2003, being the production of these metabolites in vitro one of the interesting alternative.…”

Section: Introductionmentioning

confidence: 99%

Improvement of friable callus production of Boerhaavia paniculata Rich and the investigation of its lipid profile by GC/MS

Souza

Berkov

Santos

2014

An. Acad. Bras. Ciênc.

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In this study, a protocol to induce high amount of friable callus of Boerhaavia paniculata RICH and a lipidomics technique were applied to investigate the profile of lipids to relate to those present in the roots of this plant that presented anti-inflammatory activity in the crude hexane extract. The callus culture was induced from seeds in solidified Murashige and Skoog medium containing different amounts of glucose and different concentrations of 2,4-Dichlorophenoxyacetic acid . The explants were kept in a germination chamber at 30±2°C with a photoperiod of 16 h under light intensity of 27 µmol m -2 s -1 for 4 weeks. The best results for friable callus formation and development of the biomass were obtained in the treatment containing 2.26 μM 2.4-D and glucose (1.5 %; w/v). Lipidomics techniques were applied in hexane fraction showing higher concentrations of the steroids β-sitosterol (3.53 mg/100 g dc-dry cells), and fatty acids, especially 2-hydroxy-tetracosanoic acid (0.34 mg/100 g dc), eicosanoic acid (86.25 mg/100 g dc), stearic acid (420.83 mg/100 g dc), tetradecanoic acid (10.74 mg/100 g dc) and linoleic acid (100.61 mg/100 g dc). The lipid profile of callus versus that found in the roots of wild plant is described in this work.

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Optimization of triple quadrupole mass spectrometer for quantitation of trace degradants of pharmaceutical compounds

Cited by 12 publications

References 11 publications

Rapid and accurate prediction of degradant formation rates in pharmaceutical formulations using high-performance liquid chromatography-mass spectrometry

Rapid and accurate prediction of degradant formation rates in pharmaceutical formulations using high-performance liquid chromatography-mass spectrometry

Study of a micro chamber quadrupole mass spectrometer

Improvement of friable callus production of Boerhaavia paniculata Rich and the investigation of its lipid profile by GC/MS

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