Optimization of the process of gelatin-ceftiofur sodium microspheres

Hao, Zhihui; Wang, Yanling; Tang, Shusheng; Wang, Gang; M, Qiu; Zhang, Ruili; Liu, Yuanyuan; Xiao, Xia

doi:10.1007/s11595-010-0132-x

Cited by 3 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SiO2-TiO2 System The Sosinsky regression model 20,21) and KTH (Kungliga Tekniska Högskolan) model [22][23][24] were used for calculating the sulfur capacities to research the desulfurization ability of certain slags in some references. In the current study, the desulfurization reaction process was simulated by FactSage software in order to further research the effect of TiO2 composition on the desulfurization ability of the CaO-A12O3-SiO2-TiO2 slag system at 1 873 K.…”

Section: Simulation On the Desulfurization Of Cao-al2o3-mentioning

confidence: 99%

Desulfurization of CaO–Al2O3–SiO2–TiO2 Slag System

Dong

Liu³

et al. 2014

ISIJ Int.

View full text Add to dashboard Cite

The desulfurization ability of CaO-Al2O3-SiO2-TiO2 slag at 1 873 K was studied through the slag-metal desulfurization experiment by using a 10 kg inductive furnace and through theoretical calculation by using thermodynamic software FactSage. The experimental index considered were the sulfur distribution coefficient of the slag (LS) and the desulphurization ratio (ηS). The effect factors were binary basicity, the mass percentage of Al2O3 and TiO2. Research results are as follows. The effect of binary basicity is significant, compared with the mass percentage factors of Al2O3 and TiO2. Under the optimal experimental conditions, with the binary basicity is 7, the mass percentage of Al2O3 is 30% and TiO2 is 3%, the corresponding highest sulfur distribution coefficient for the slag are 58.14. While the content of TiO2 in the CaO-Al2O3-SiO2-TiO2 slag is in a range lower than 3-4%, the desulfurization ability of the CaO-Al2O3-SiO2-TiO2 slag is equal to that of the CaO-Al2O3-SiO2 slag. The slag system with TiO2 can meet the desulfurization requirements of steelmaking, which is a good way for resource utilization of solid waster containing titanium.

show abstract

Section: Simulation On the Desulfurization Of Cao-al2o3-mentioning

confidence: 99%

Desulfurization of CaO–Al2O3–SiO2–TiO2 Slag System

Dong

Liu³

et al. 2014

ISIJ Int.

View full text Add to dashboard Cite

show abstract

In vivo investigation of ceftiofur-loaded gelatin and PLGA microspheres in beagle dogs

Hao

Wang

Xiao

et al. 2013

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Drug delivery systems based on polymer microspheres have received considerable attention. Ceftiofur sodium and ceftiofur hydrochloride is widely used for the treatment of bacterial diseases in animals but the delivery in vivo has not been reported. In this paper, we report the synthesis of microspheres from gelatin and PLGA, two kinds of typical natural and artificial materials, for loading ceftiofur and the in vivo investigation of the pharmacokinetics in beagle dogs. By controlling the synthesis parameters, gelatin and PLGA microspheres with diameter between 5 and 35 microns were obtained. Assay procedures based on high performance liquid chromatography were evaluated and confirmed. The dogs were randomly divided into three groups, i.e., control group, gelatin group, and PLGA group and administrated via intravenous injection. Plasma concentrations of ceftiofur over time were measured and analyzed. Results indicate that the main kinetic parameters do not show significant difference for the gelatin group and control group, but the area under the curve, plasma half-life, apparent volume of distribution, and clearance ratio of PLGA group show significant difference from the gelatin group and the control group. The PLGA microspheres show a low area under the curve but long time release.

show abstract