An analysis of the microencapsulation of ceftiofur in chitosan particles using the spray drying technology

Helbling, Ignacio Marcelo; Busatto, Carlos Alberto; Karp, Federico; Islan, Germán Abel; Estenoz, Diana Alejandra; Luna, Julio Alberto

doi:10.1016/j.carbpol.2020.115922

Cited by 7 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The spray drying process usually includes four stages: atomization, droplet mixing with dry gas, solvent volatilization, and product separation, in which the technological conditions and parameters of the atomization process play a decisive role in the droplet size distribution (Ré, 2006 ; Liu et al, 2015 ; Deshmukh et al, 2016 ; Messa et al, 2020 ), such as the selection of atomizer, nozzle pressure, feed or air flow rate, etc (Bowey & Neufeld, 2010 ; Shi et al, 2020 ). The spray drying method can generate particles in one step quickly and continuously, eliminating the need for a separate drying process in other preparation methods (Helbling et al, 2020 ; Ozturk & Kiyan, 2020 ; Yurtdas & Ozturk, 2020 ). The entire preparation process is automated, and a relatively high encapsulation rate can be obtained (Calegari et al, 2020 ), which is suitable for the encapsulation of proteins or peptides (Aydin, 2020 ; Shi et al, 2020 ), plasmid DNA (Walter et al, 2001 ; Atuah et al, 2003 ; Jilek et al, 2004 ), and small molecule drugs (Waldron et al, 2014 ).…”

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

264

106

View full text Add to dashboard Cite

Biodegradable microspheres have been widely used in the field of medicine due to their ability to deliver drug molecules of various properties through multiple pathways and their advantages of low dose and low side effects. Poly (lactic-co-glycolic acid) copolymer (PLGA) is one of the most widely used biodegradable material currently and has good biocompatibility. In application, PLGA with a specific monomer ratio (lactic acid and glycolic acid) can be selected according to the properties of drug molecules and the requirements of the drug release rate. PLGA-based biodegradable microspheres have been studied in the field of drug delivery, including the delivery of various anticancer drugs, protein or peptide drugs, bacterial or viral DNA, etc. This review describes the basic knowledge and current situation of PLGA biodegradable microspheres and discusses the selection of PLGA polymer materials. Then, the preparation methods of PLGA microspheres are introduced, including emulsification, microfluidic technology, electrospray, and spray drying. Finally, this review summarizes the application of PLGA microspheres in drug delivery and the treatment of pulmonary and ocularrelated diseases.

show abstract

Section: Preparation Methods Of Plga Microspherementioning

confidence: 99%

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Zhang²,

Sun³

et al. 2021

Drug Delivery

264

106

View full text Add to dashboard Cite

show abstract

“…On the other hand, the reduction in the indiscriminate use of antibiotics is a matter of increasing interest due to the emergence of microbial antibiotic resistance (MDR) declared by the WHO. In this sense, DDT designed for antibiotics encapsulation intent to overcome the mentioned problems 1,2,22 . Tilmicosin (Til) is a slightly water soluble macrolide antibiotic synthesized from tylosin.…”

Section: Introductionmentioning

confidence: 99%

“…In this sense, DDT designed for antibiotics encapsulation intent to overcome the mentioned problems. 1,2,22 Tilmicosin (Til) is a slightly water soluble macrolide antibiotic synthesized from tylosin. It has a very good activity against Gram-positive microorganisms, with significant activity against certain Gram-negative bacteria and mycoplasma.…”

Section: Introductionmentioning

confidence: 99%

Modulating drug release from poly(lactic‐co‐glycolic) acid microparticles by the addition of alginate and pectin

Karp

Satler

Busatto

et al. 2020

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

The aim of the present work is the characterization of PLGA microparticles including biopolymers for the controlled release of tilmicosin, a broad‐spectrum antibiotic. Microparticles were prepared using the double‐emulsion solvent evaporation technique. The effect of alginate and pectin incorporation over particle size and porosity, encapsulation efficiency (EE) and pH‐responsive drug release was evaluated. Formulations presented a mean particle size of 5.5 μm approximately and a drug EE ranged from 22%–57%. PLGA‐Alginate particles showed an increased porosity. Tilmicosin release profiles from PLGA and PLGA‐biopolymer microparticles were affected by the particular combination of polymers and the pH of the release medium. The experimental data was simulated using a mathematical model, which takes into account the autocatalytic polymer degradation and the different mechanisms of drug transport. The combination of PLGA and biopolymers strongly influenced the morphology of the particles, offering the possibility of controlling the drug release profiles according to the therapy.

show abstract

“…In AA + NIC CMs, the loss of chitosanthermal event at 89.9 °C was due to the drying process in the microencapsulation procedure; the presence of a new band formed at 108 °C and 161 °C can be related to the glass transition temperature from chitosan, values that are usually obtained in formulations based on this polymer [ 25 , 26 ]. In addition, Helbling et al (2020) indicated that obtaining a band at 161 °C could also be related to the crystallization of the drug from chitosan microparticles and the presence of various crystalline forms [ 27 ]. Ionic polymers such as chitosan can electrostatically attract bioactive substances or drugs that ionize in solution with reverse polarity to that of the polymer, forming a physical attraction that modifies the thermal response of the formulations [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide

Filippo

Duarte

Roque‐Borda

et al. 2022

Life

View full text Add to dashboard Cite

Vitamins are widely found in nature, for example, in plants and fruits. Ascorbic acid and nicotinamide are examples of these compounds that have potent antioxidant properties, besides stimulating collagen production and depigmenting properties that protect the skin from premature aging. To overcome the skin barrier and reduce the instability of antioxidant compounds, alternative systems have been developed to facilitate the delivery of antioxidants, making them efficiently available to the tissue for an extended time without causing damage or toxicity. The objective of this study was to obtain chitosan biodegradable microparticles containing ascorbic acid and nicotinamide for topical delivery. The microparticles were obtained by spray drying and characterized chemically by means of scanning electron microscopy, infrared spectroscopy, X-ray diffraction, and differential exploratory calorimetry. The drugs were successfully encapsulated and the microparticles showed positive zeta potential. In vitro release assays showed a sustained release profile. The evaluation of ex vivo skin permeation and retention demonstrated low permeation and adequate retention of the compounds in the epidermis/dermis, suggesting the efficient delivery from the obtained microparticles. Antibacterial assays have shown that microparticles can inhibit the growth of microorganisms in a time- and dose-dependent manner, corroborating their use in cosmetic products for application on the skin.

show abstract

An analysis of the microencapsulation of ceftiofur in chitosan particles using the spray drying technology

Cited by 7 publications

References 39 publications

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application

Modulating drug release from poly(lactic‐co‐glycolic) acid microparticles by the addition of alginate and pectin

In Vitro Skin Co-Delivery and Antibacterial Properties of Chitosan-Based Microparticles Containing Ascorbic Acid and Nicotinamide

Contact Info

Product

Resources

About