2012
DOI: 10.1016/j.chroma.2012.01.072
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Optimization of the liquid chromatography enantioseparation of chiral acidic compounds using cellulose tris(3-chloro-4-methylphenylcarbamate) as chiral selector and polar organic mobile phases

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Cited by 32 publications
(19 citation statements)
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“…Thus, in the last years a large number of separation (screening and optimizations steps) and chemiometric strategies for the enantioseparation of pharmaceuticals on polysaccharide-based CSPs in NP, 48 PO, 49,50 RP, 51 multimodal elution mode, 52 and SFC 53,54 has been reported. Four chromatographic method development platforms were used, among which were chiral SFC on 12 polysaccharide-based columns (150 × 4.6 mm, 3 μm) (mobile phases: 25 mM isobutylamine in ROH/CO 2 ).…”
Section: Halogens In Hplc Enantioseparationsmentioning
confidence: 99%
“…Thus, in the last years a large number of separation (screening and optimizations steps) and chemiometric strategies for the enantioseparation of pharmaceuticals on polysaccharide-based CSPs in NP, 48 PO, 49,50 RP, 51 multimodal elution mode, 52 and SFC 53,54 has been reported. Four chromatographic method development platforms were used, among which were chiral SFC on 12 polysaccharide-based columns (150 × 4.6 mm, 3 μm) (mobile phases: 25 mM isobutylamine in ROH/CO 2 ).…”
Section: Halogens In Hplc Enantioseparationsmentioning
confidence: 99%
“…However, the development of a variety of chiral selectors not only made a breakthrough in chiral compound separation but also let the chiral compound analysis a routine work. In recent years, the separation and analysis of chiral compounds using liquid chromatography (LC) [11][12][13], gas chromatography (GC) [14][15][16], and capillary electrophoresis (CE) [11,17] or micellar electrokinetic chromatography (MEKC) [18] have been successively reported to explore many new chiral compounds. In these studies, LC was the first to apply for the chiral compound analysis that leads a rapid and more extensive development of chiral stationary phases (CSPs) than other chromatographies [10,19].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, direct stereoselective methods are generally preferred for the separation of ketorolac enantiomers. The chiral resolution of ketorolac has been carried out using several chiral columns, particularly protein‐based chiral stationary phases (α1‐acid glycoprotein, AGP, human serum albumin [has]), macrocyclic glycoprotein, and polysaccharide‐based stationary phases of derivatized cellulose, or amylose chiral selectors. In protein‐based columns, the separation power may decrease with an increasing number of samples and vary from one column to another.…”
Section: Introductionmentioning
confidence: 99%
“…The other problem with the use of the AGP columns is their high cost and short lifetime. Also, reported methods described for the separation of KET enantiomers with polysaccharide‐based columns either used expensive instrumentation or were concerned only with the separation without any quantitation data …”
Section: Introductionmentioning
confidence: 99%
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