Optimization of Tablet Formulations Containing

Dawoodbhai, Talc S.; Suryanarayan, E. R.; Woodruff, Connor; Rhodes, C. T.

doi:10.3109/03639049109057301

Cited by 27 publications

(8 citation statements)

References 22 publications

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“…This was described by Klein et al [7], and it was developed for controlled release of semen for artificial insemination in swine [8][9][10] and for 3D culture of ovarian follicular cells [11][12][13]. Recently, this technique has also been employed in 3D culture of other cell types: nucleus pulposus for regenerative therapy of intervertebral disc and adipose derived mesenchymal stem cells for in vitro expansion [14]. The barium alginate capsules are formed from a core containing the live cells surrounded by a gel membrane which may, if desired, be coated by an external layer of protamine-reacted alginate.…”

Section: Introductionmentioning

confidence: 98%

Statistical approach in alginate membrane formulation for cell encapsulation in a GMP-based cell factory

et al. 2008

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Section: Introductionmentioning

confidence: 98%

Statistical approach in alginate membrane formulation for cell encapsulation in a GMP-based cell factory

et al. 2008

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“…Dawoodbhai et al [81] optimized the formulation of direct compression tablet products containing talc using SQP methodologies. The tablet dissolution and disintegration time in vitro was optimized from experimentally measurable manufacturing parameters such as friability, hardness, compression and ejection force.…”

Section: Product Formulationmentioning

confidence: 99%

“…All of these parameters were determined within feasible manufacturing values, which generated regions that served as the constraints for the SQP optimization. The characteristics and results of the optimized tablet formulation were analyzed by principal component analysis and described using response surface modeling [81].…”

Section: Product Formulationmentioning

confidence: 99%

Optimization Methodologies for the Production of Pharmaceutical Products

Escotet‐Espinoza

Rogers

Ierapetritou

2016

Methods in Pharmacology and Toxicology

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Finding the most beneficial conditions during the development of a given product or process is among one of the top goals for both scientist and engineers across all industries. In the pharmaceutical industry, as global competition increases and there is a higher demand for accessible quality products, it is important to focus on the improvement of product development and manufacturing. Optimization methodologies can greatly aid the production of pharmaceutical products by providing a systematic framework to process improvement. In this review, general concepts regarding the implementation of optimization methods are introduced along with examples of their application in pharmaceutical manufacturing process design and formulation development. An overview of optimization methodologies used for the improvement of batch and continuous pharmaceutical manufacturing is presented. Challenges in the application of optimization methods in pharmaceutical manufacturing are discussed along with a future outlook of the field and its place in pharmaceutical process and product design. Overall the review points to optimization as a critical component in the design of improved and effective pharmaceutical products, in alignment with the common goals of both regulatory agencies and industry.

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“…The application of an optimization technique consisting of statistical design to pharmaceutical formulation development provides an efficient and economical method to acquire the necessary information to understand the relationship between controllable (independent) variables and performance dependent variables or responses (9). The technique of optimization is well reported in the literature for the development of tablet formulations (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Studies on Formulation Development of Mucoadhesive Sustained Release Itraconazole Tablet Using Response Surface Methodology

2008

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Abstract. The purpose of this research was to prepare and evaluate sustained release mucoadhesive tablets of Itraconazole. It is practically insoluble in aqueous fluids hence its solid dispersion with Eudragit E100 was prepared by spray drying. This was formulated in matrix of hydrophilic mucoadhesive polymers Carbopol 934P (CP) and Methocel K4M (HPMC). The formulation was optimized using a 3 2 factorial design. Amounts of CP and HPMC were taken as formulation variables for optimizing response variables i.e. mucoadhesion and dissolution parameters. The optimized mucoadhesive formulation was orally administered to albino rabbits, and blood samples collected were used to determine pharmacokinetic parameters. The solid dispersion markedly enhanced the dissolution rate of itraconazole. The bioadhesive strength of formulation was found to vary linearly with increasing amount of both polymers. Formulations exhibited drug release fitting Peppas model with value of n ranging from 0.61 to 1.18. Optimum combination of polymers was arrived at which provided adequate bioadhesive strength and fairly regulated release profile. The experimental and predicted results for optimum formulations were found to be in close agreement. The formulation showed C max 1898± 75.23 ng/ml, t max of the formulation was 2 h and AUC was observed to be 28604.9 ng h/ml

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Optimization of Tablet Formulations Containing

Cited by 27 publications

References 22 publications

Statistical approach in alginate membrane formulation for cell encapsulation in a GMP-based cell factory

Statistical approach in alginate membrane formulation for cell encapsulation in a GMP-based cell factory

Optimization Methodologies for the Production of Pharmaceutical Products

Studies on Formulation Development of Mucoadhesive Sustained Release Itraconazole Tablet Using Response Surface Methodology

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