Optimization of scaffold design for bone tissue engineering: A computational and experimental study

Dias, M.; Guedes, J. M.; Flanagan, Colleen L.; Hollister, Scott J.; Fernandes, Paulo R.

doi:10.1016/j.medengphy.2014.02.010

Cited by 138 publications

(76 citation statements)

References 30 publications

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“…Using these methodologies, pore geometry is not dependent on the stochastic spatial distribution of pores or porogens; instead, pore geometry can be designed and printed. Indeed [9][10][11], these new manufacturing technologies are driving an increasing amount of research on pore geometry. In general, the size and shape of pores within the scaffold must balance mechanical integrity with bioactive molecule delivery, tissue infusion, and degradation characteristics [5,12].…”

Section: Introductionmentioning

confidence: 99%

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

et al. 2017

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“…The general workflow of TO for 3D printing can be found in the following review [86]. Many researchers have done relevant works [87][88][89][90][91][92]. Unfortunately, to the best of the authors' knowledge, only seven papers are related to the reduction of the support structure.…”

Section: Optimizing the Topology To Reduce Support Usedmentioning

confidence: 99%

Support Structures for Additive Manufacturing: A Review

Jiang

Stringer

2018

JMMP

280

154

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Additive manufacturing (AM) has developed rapidly since its inception in the 1980s. AM is perceived as an environmentally friendly and sustainable technology and has already gained a lot of attention globally. The potential freedom of design offered by AM is, however, often limited when printing complex geometries due to an inability to support the stresses inherent within the manufacturing process. Additional support structures are often needed, which leads to material, time and energy waste. Research in support structures is, therefore, of great importance for the future and further improvement of additive manufacturing. This paper aims to review the varied research that has been performed in the area of support structures. Fifty-seven publications regarding support structure optimization are selected and categorized into six groups for discussion. A framework is established in which future research into support structures can be pursued and standardized. By providing a comprehensive review and discussion on support structures, AM can be further improved and developed in terms of support waste in the future, thus, making AM a more sustainable technology.

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“…Such structures should have appropriate geometrical and mechanical properties in order to provide suitable bone treatment (Giannitelli et al, 2014;Sanz-Herrera et al, 2008;Yang et al, 2001). In this regard, Dias et al (Dias et al, 2014) proposed a topology optimization algorithm for designing scaffolds that satisfy both mass transport and mechanical load bearing capacity.…”

Section: Introductionmentioning

confidence: 99%

Numerical investigation of the mechanical properties of the additive manufactured bone scaffolds fabricated by FDM: the effect of layer penetration and post-heating

Naghieh¹,

Karamooz-Ravari²,

Badrossamay³

et al. 2017

Preprint

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In recent years, thanks to additive manufacturing technology, researchers have gone towards the optimization of bone scaffolds for the bone reconstruction. Bone scaffolds should have appropriate biological as well as mechanical properties in order to play a decisive role in bone healing. Since the fabrication of scaffolds is time consuming and expensive, numerical methods are often utilized to simulate their mechanical properties in order to find a nearly optimum one. Finite element analysis is one of the most common numerical methods that is used in this regard. In this paper, a parametric finite element model is developed to assess the effects of layer adhesion on the mechanical properties of bone scaffolds. To be able to validate this model, some compression test specimens as well as bone scaffolds are fabricated with biocompatible and biodegradable poly lactic acid using fused deposition modeling. All these specimens are tested in compression and their elastic modulus is obtained. Using the material parameters of the compression test specimens, the finite element analysis of the bone scaffold is performed. The obtained elastic modulus is compared with experiment indicating a good agreement. Accordingly, the proposed finite element model is able to predict the mechanical behavior of fabricated bone scaffolds accurately. In addition, the effect of post-heating of bone scaffolds on their elastic modulus is investigated. The results demonstrate that the numerically predicted elastic modulus of scaffold is closer to experimental outcomes in comparison with as-build samples.

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Optimization of scaffold design for bone tissue engineering: A computational and experimental study

Cited by 138 publications

References 30 publications

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

Design and mechanical characterization of solid and highly porous 3D printed poly(propylene fumarate) scaffolds

Support Structures for Additive Manufacturing: A Review

Numerical investigation of the mechanical properties of the additive manufactured bone scaffolds fabricated by FDM: the effect of layer penetration and post-heating

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