Optimization of photocrosslinkable resin components and 3D printing process parameters

Guerra, Antonio J.; Lindemann, J.; Katko, Alex; Kleinfehn, Alex; Rodrı́guez, Ciro A.; Catalani, Luiz H.; Becker, Matthew L.; Ciurana, Joaquim; Dean, David

doi:10.1016/j.actbio.2019.07.045

Cited by 47 publications

(41 citation statements)

References 13 publications

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“…In addition to materials and structural optimization, the process parameters should be adjusted and optimized to manufacture scaffolds with desired attributes. Numerous studies investigated the effect of process parameters on different responses such as mechanical properties (strength, elongation, Young's modulus), surface roughness, resolution and dimensional accuracy, and printing quality in different techniques including SLA [221][222][223][224], SLS [225][226][227][228][229][230][231][232][233][234], EBM [235][236][237][238][239][240][241], LENS [242,243], SLM [39,[244][245][246][247][248][249][250], 2PP [251][252][253], FDM [254][255][256], MJ [257,258], AJP [259][260][261][262], and IJP [263]…”

Section: D Printing Process Optimizationmentioning

confidence: 99%

“…In addition to materials and structural optimization, the process parameters should be adjusted and optimized to manufacture scaffolds with desired attributes. Numerous studies investigated the effect of process parameters on different responses such as mechanical properties (strength, elongation, Young’s modulus), surface roughness, resolution and dimensional accuracy, and printing quality in different techniques including SLA [ 221 – 224 ], SLS [ 225 – 234 ], EBM [ 235 – 241 ], LENS [ 242 , 243 ], SLM [ 39 , 244 – 250 ], 2PP [ 251 – 253 ], FDM [ 254 – 256 ], MJ [ 257 , 258 ], AJP [ 259 – 262 ], and IJP [ 263 – 266 ]. There are many parameters in the 3D printing approaches which vary between different techniques as their machine structure, printing mechanisms, and materials used are rather different.…”

Section: D Printing Of Bone Scaffold Based On Cad Modelmentioning

confidence: 99%

“…Among the studies on process parameters, some have used systematical methodologies including DOE and response surface methodology (RSM) such as Taguchi, two-level factorial, Box–Behnken, and central composite designs [ 221 , 222 , 228 , 230 , 234 , 244 , 245 , 247 , 253 – 255 , 260 , 263 , 266 ]. A response surface methodology is an optimization approach and a collection of statistical and mathematical approaches utilized to accomplish the multi-objective optimization procedure in various systems including materials, geometry and process.…”

Section: D Printing Of Bone Scaffold Based On Cad Modelmentioning

confidence: 99%

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Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

145

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Background Bones in human body are prone to damage due to different causes such as fractures, diseases, and infections. Nevertheless, they have a remarkable capacity to repair and heal themselves after trauma and illness. Large defects, however, are never completely reinstated because their sizes are beyond the limit up to which the bones can repair [1]. In these conditions, therefore, a medical remedy is required to stabilize, align and support the damaged bone region to restore the lost function. Bone autografts are considered the gold standard treatment. However, they have a number of shortcomings including the limited sources and donor site morbidity. Allografts also have the risk of immune rejection and disease transmission [2, 3]. Therefore, the research has headed for other solutions via tissue engineering. Bone tissue engineering provides three-dimensional (3D)

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Section: D Printing Process Optimizationmentioning

confidence: 99%

“…In addition to materials and structural optimization, the process parameters should be adjusted and optimized to manufacture scaffolds with desired attributes. Numerous studies investigated the effect of process parameters on different responses such as mechanical properties (strength, elongation, Young’s modulus), surface roughness, resolution and dimensional accuracy, and printing quality in different techniques including SLA [ 221 – 224 ], SLS [ 225 – 234 ], EBM [ 235 – 241 ], LENS [ 242 , 243 ], SLM [ 39 , 244 – 250 ], 2PP [ 251 – 253 ], FDM [ 254 – 256 ], MJ [ 257 , 258 ], AJP [ 259 – 262 ], and IJP [ 263 – 266 ]. There are many parameters in the 3D printing approaches which vary between different techniques as their machine structure, printing mechanisms, and materials used are rather different.…”

Section: D Printing Of Bone Scaffold Based On Cad Modelmentioning

confidence: 99%

Section: D Printing Of Bone Scaffold Based On Cad Modelmentioning

confidence: 99%

See 1 more Smart Citation

Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

145

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“…Notwithstanding the huge amount of research performed so far, novel polymers and resin components may be needed, along with a more systematic approach to process optimization. Moving toward this direction, Guerra et al [ 72 ] investigated the effects of poly(propylene fumarate) resin components on 3D printing process parameters, with a particular emphasis for the methodological soundness.…”

Section: Bioprintingmentioning

confidence: 99%

Advances on Bone Substitutes through 3D Bioprinting

Genova

Roato

Carossa

et al. 2020

IJMS

101

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Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

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“…In addition, the printing parameters also exert a great impact on the photocuring process and printing fidelity. For example, exposure time, voxel depth, and over-curing depth significantly affected the curing behavior of different photosensitive resins [16]. Although sufficient light intensity and exposure time were essential for photocuring, excessive exposure time might reduce printing resolution owing to the overgrowth caused by light scattering [17].…”

Section: Introductionmentioning

confidence: 99%

Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique

et al. 2020

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The high printing efficiency and easy availability of desktop digital light processing (DLP) printers have made DLP 3D printing a promising technique with increasingly broad application prospects, particularly in personalized medicine. The objective of this study was to fabricate and evaluate medical samples with external and internal structures using the DLP technique. The influence of different additives and printing parameters on the printability and functionality of this technique was thoroughly evaluated. It was observed that the printability and mechanical properties of external structures were affected by the poly(ethylene glycol) diacrylate (PEGDA) concentration, plasticizers, layer height, and exposure time. The optimal printing solutions for 3D external and internal structures were 100% PEGDA and 75% PEGDA with 0.25 mg/mL tartrazine, respectively. And the optimal layer height for 3D external and internal structures were 0.02 mm and 0.05 mm, respectively. The optimal sample with external structures had an adequate drug-loading ability, acceptable sustained-release characteristics, and satisfactory biomechanical properties. In contrast, the printability of internal structures was affected by the photoabsorber, PEGDA concentration, layer height, and exposure time. The optimal samples with internal structures had good morphology, integrity and perfusion behavior. The present study showed that the DLP printing technique was capable of fabricating implants for drug delivery and physiological channels for in vivo evaluation.

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Optimization of photocrosslinkable resin components and 3D printing process parameters

Cited by 47 publications

References 13 publications

Challenges on optimization of 3D-printed bone scaffolds

Challenges on optimization of 3D-printed bone scaffolds

Advances on Bone Substitutes through 3D Bioprinting

Printability of External and Internal Structures Based on Digital Light Processing 3D Printing Technique

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