Optimization of operating frequency of acoustic transducers for obtaining maximum temperature in HIFU based therapeutic ablation

Bozkurt, Ayhan; Roy, Rupak Bardhan; Erguni, Sanli

doi:10.1109/ultsym.2012.0147

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…4 not only holds for focused waves but also can be extended to inhomogeneous media by replacing α 0 with an average frequency independent attenuation coefficient. A FEM simulation study was also done showing results along the same line as well [4]. …”

Section: Analytical Backgroundmentioning

confidence: 99%

Frequency optimization in high intensity focused ultrasound

Yetik

Arıyürek

Bozkurt

et al. 2014

2014 IEEE International Ultrasonics Symposium

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In high intensity focused ultrasound (HIFU) the choice of transducer frequency depends on the target depth and tissue type. At high frequencies attenuation does not permit enough acoustical power to be transmitted to the target whereas at low frequencies the transmitted power is not absorbed efficiently. Hence, there exists an optimum frequency at which the power deposited at the target is maximum. In this study, we verified this relation experimentally using MR compatible focused transducers, ex-vivo tissue samples and magnetic resonance (MR) thermometry. © 2014 IEEE

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Section: Analytical Backgroundmentioning

confidence: 99%

Frequency optimization in high intensity focused ultrasound

Yetik

Arıyürek

Bozkurt

et al. 2014

2014 IEEE International Ultrasonics Symposium

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Fabrication of High-Efficiency CMUTs With Reduced Parasitics Using Embedded Metallic Layers

et al. 2017

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Integrated HIFU Drive System on a Chip for CMUT-Based Catheter Ablation System

Farhanieh

Sahafi

Roy

et al. 2017

IEEE Trans. Biomed. Circuits Syst.

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Conventional High Intensity Focused Ultrasound (HIFU) is a therapeutic modality which is extracorporeally administered. In applications where a relatively small HIFU lesion is required, an intravascular HIFU probe can be deployed to the ablation site. In this paper, we demonstrate the design and implementation a fully integrated HIFU drive system on a chip to be placed on a 6 Fr catheter probe. An 8-element capacitive micromachined ultrasound transducer (CMUT) ring array of 2 mm diameter has been used as the ultrasound source. The driver chip is fabricated in 0.35 μm AMS high-voltage CMOS technology and comprises eight continuous-wave (CW) high-voltage CMUT drivers (10.9 ns and 9.4 ns rise and fall times at 20 V output into a 15 pF), an eight-channel digital beamformer (8-12 MHz output frequency with 11.25 phase accuracy) and a phase locked loop with an integrated VCO as a tunable clock source (128-192 MHz). The chip occupies 1.85 × 1.8 mm area including input and output (I/O) pads. When the transducer array is immersed in sunflower oil and driven by the IC with eight 20 V CW pulses at 10 MHz, real-time thermal images of the HIFU beam indicate that the focal temperature rises by 16.8 C in 11 seconds. Each HV driver consumes around 67 mW of power when driving the CMUT array at 10 MHz, which adds up to 560 mW for the whole chip. FEM based analysis reveals that the outer surface temperature of the catheter is expected to remain below the 42C tissue damage limit during therapy.

show abstract

Optimization of operating frequency of acoustic transducers for obtaining maximum temperature in HIFU based therapeutic ablation

Cited by 3 publications

References 5 publications

Frequency optimization in high intensity focused ultrasound

Frequency optimization in high intensity focused ultrasound

Fabrication of High-Efficiency CMUTs With Reduced Parasitics Using Embedded Metallic Layers

Integrated HIFU Drive System on a Chip for CMUT-Based Catheter Ablation System

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