Optimization of Oleoresin Extraction fromCurcuma longaL. Using RSM and Determination of Equilibrium Constant

Abstract

The effect of independent variables of Soxhlet extraction; temperature (35-55C), solvent-to-solid ratio (5-25, g/g) and particle size (0.15-0.6 mm) on oleoresin yield (% db), curcumin yield (% db) as well as total phenolic content (TPC) of extracts was investigated. Response surface methodology was used for optimization and the high correlation of the mathematical models indicated that a quadratic polynomial model could be used for optimization of the investigated responses. Multiresponse optimization study indicated that the optimum conditions for the extraction were extraction temperature 48.94C, solvent-to-solid ratio 20.95 and particle size 0.24 mm. The optimized conditions yielded 9.57% of oleoresin (db), 3.33% curcumin (db) and TPC 13.73 mg GAE/g. From the initial data of optimization, equilibrium studies were conducted considering the optimum particle size (0.24 mm) in a batch extractor at different temperatures ranging from room temperature (28C) to 50C. The equilibrium constant varied between 4.39 and 13.71 under these temperatures. PRACTICAL APPLICATIONIn this manuscript, response surface methodology approach has been used as an important research tool to evaluate the effect of different process variables on oleoresin extraction from turmeric. Also, an insight into equilibrium distribution relationship will help in equipment design and scaling up the extraction process.

Effect of particle size on yield extract and antioxidant activity of peanut skin using modified supercritical carbon dioxide and soxhlet extraction

“…Different finding was also observed in this trend, where extraction of fat from oleaginous seeds with particle size 2 mm gave the highest percentage yield extract (40.116%) compared with sizes between 3 and 4 mm (Luque‐Garcıa & De Castro, ). It has been reported that increasing of particle size from 0.24 to 0.6 mm increase the yield extract until 9.57% on the extraction of oleoresin from Curcuma Longa L (Haldar, Mishra, & Majumdar, ). A similar trend was found in this research, where extraction of oleifera seeds oil with particle size of 1 mm gave the highest yield extract (42.1%) in the range of particle size (0.5–2 mm) (Eman & Muhamad, ).…”

Experimental and numerical study on a novel microfluidic method to fabricate curcumin loaded calcium alginate microfibres

“…For loading curcumin as a hydrophobic anti‐cancer drug on microfibres, curcumin extraction from turmeric was performed according to Haldar's protocol . Briefly, 0.5 g of 4.5 mg/mL of curcumin was mixed with 1 mg/mL sodium alginate solution containing 0.017 M Tween 60 for 15 min by magnet stirrer.…”

“…For loading curcumin as a hydrophobic anti-cancer drug on microfibres, curcumin extraction from turmeric was performed according to Haldar's protocol. [45] Briefly, 0.5 g of 4.5 mg/mL of curcumin was mixed with 1 mg/mL sodium alginate solution containing 0.017 M Tween 60 for 15 min by magnet stirrer. The percentage of curcumin in the gelatin complex was measured based on spectrophotometry in 420 nm of a 0.6 mg/L of aqueous solution.…”

Identification of the Appropriate Curing Method for Sri Lankan Turmeric (Curcuma longa L.) and Compare its Phytochemical Properties with an Indian Market Sample

“…The total phenolic content is changed with the extraction temperature, solvent-to-solid ratio, and particle size. Some researchers have described, total phenolic content increased when increase the extraction temperature up to 53.75 o C. However, total phenolic content is decreased when the temperature goes up further according to research performed by Haldar et al [32]. Hirun et al [23] indicated that the amount of total phenolic content in turmeric varies with growth area, harvesting season, and turmeric varieties.…”