Optimization of extraction method and evaluation of antileishmanial activity of oil and nanoemulsions of Pterodon pubescens benth. fruit extracts

Santos, Éverton da Silva; Garcia, Francielle P.; Outuki, Priscila Miyuki; Hoscheid, Jaqueline; Góes, Paulo Roberto Nunes de; Cardozo‐Filho, Lúcio; Nakamura, Celso Vataru; Cardoso, Mara Lane Carvalho

doi:10.1016/j.exppara.2016.10.004

Cited by 18 publications

(2 citation statements)

References 42 publications

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“…Pterodon pubescens : The components extraction from P. pubescens by ‘Supercritical CO 2 extraction’ (scCO 2 ), which does not use organic solvents and is environmentally sustainable, detected high geranylgeraniol and 14,15-epoxy-geranylgeraniol content (da Silva Santos et al ., 2016). This extract had high inhibitory activity against intracellular amastigotes of L. amazonensis (IC 50 1.9 μ g mL −1 ), and the effect was likely due to the high geranylgeraniol derivative content of the fluid, which resulted in superoxide anion production, leading to parasite death (Lopes et al ., 2012; da Silva Santos et al ., 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of essential oils on Leishmania amazonensis: a systematic review

et al. 2020

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This systematic review investigated the evidence for the therapeutic potential of essential oils (EOs) against Leishmania amazonensis. We searched available scientific publications from 2005 to 2019 in the PubMed and Web of Science electronic databases, according to PRISMA statement. The search strategy utilized descriptors and free terms. The EOs effect of 35 species of plants identified in this systematic review study, 45.7% had half of the maximal inhibitory concentration (IC50) 10 < IC50 ⩽ 50 μg mL−1 and 14.3% had a 10 < IC50μg mL−1 for promastigote forms of L. amazonensis. EOs from Cymbopogon citratus species had the lowest IC50 (1.7 μg mL−1). Among the plant species analyzed for activity against intracellular amastigote forms of L. amazonensis, 39.4% had an IC50 10 < IC50 ⩽ 50 μg mL−1, and 33.3% had an IC50 10 < IC50μg mL−1. Aloysia gratissima EO showed the lowest IC50 (0.16 μg mL−1) for intracellular amastigotes. EOs of Chenopodium ambrosioides, Copaifera martii and Carapa guianensis, administered by the oral route, were effective in reducing parasitic load and lesion volume in L. amazonensis-infected BALB/c mice. EOs of Bixa orellana and C. ambrosioides were effective when administered intraperitoneally. Most of the studies analyzed in vitro and in vivo for the risk of bias showed moderate methodological quality. These results indicate a stimulus for the development of new phytotherapy drugs for leishmaniasis treatment.

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Section: Discussionmentioning

confidence: 99%

Effect of essential oils on Leishmania amazonensis: a systematic review

et al. 2020

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“…In addition, to further prevent the bioactive constituents from probable chemical degradation, chitosan was combined with another biopolymer, alginate, to microencapsulate the oleaginous fraction obtained from the fruit of Pterodon pubescens Benth [ 49 ], which has a variety of bioactivities, such as antinociception [ 68 ], antileishmaniasis [ 69 ], and antiproliferation [ 70 ]. By virtue of measuring the concentration of four bioactive components (vouacapan 1–4) included in the fraction, the microcapsules comprised of alginate and low-molecular-weight chitosan showed the largest microencapsulation efficiency, compared to those consisting of alginate and medium-molecular-weight chitosan or alginate and chitosan with more than 75% deacetylation (61.01 ± 2.00% vs. 47.07 ± 2.01% or 57.17 ± 1.63%).…”

Section: Physical Maskingmentioning

confidence: 99%

Developments in Taste-Masking Techniques for Traditional Chinese Medicines

Zheng

Yang

et al. 2018

Pharmaceutics

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A variety of pharmacologically active substances, including chemotherapeutic drugs and the substances from traditional Chinese medicine (TCM), always exhibit potent bioactivities after oral administration. However, their unpleasant taste (such as bitterness) and/or odor always decrease patient compliance and thus compromise their curative efficacies in clinical application. Therefore, the developments of taste-masking techniques are of great significance in improving their organoleptic properties. However, though a variety of taste-masking techniques have been successfully used to mask the unpalatable taste of chemotherapeutic drugs, their suitability for TCM substances is relatively limited. This is mainly due to the fact that the bitter ingredients existing in multicomponent TCM systems (i.e., effective fractions, single Chinese herbs, and compound preparations) are always unclear, and thus, there is lack of tailor-made taste-masking techniques to be utilized to conceal their unpleasant taste. The relevant studies are also relatively limited. As a whole, three types of taste-masking techniques are generally applied to TCM, including (i) functional masking via sweeteners, bitter blockers, and taste modifiers; (ii) physical masking via polymer film-coating or lipid barrier systems; and (iii) biochemical masking via intermolecular interaction, β-cyclodextrin inclusion, or ion-exchange resins. This review fully summarizes the results reported in this field with the purpose of providing an informative reference for relevant readers.

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