Optimization of chemometric approaches for the extraction of isorhamnetin-3-O-rutinoside from Calendula officinalis L.

Moraes, Maria de Lourdes Leite de; Silva, Heron Dominguez Torres da; Blanes, Lucas; Doble, Philip; Tavares, Marina Franco Maggi

doi:10.1016/j.jpba.2016.04.017

Cited by 11 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In grape, their content may reach 1 and 2 mg/kg (calculated as total syringetin glycoside); in blueberry, the values are up to 3.5 and 2.5 mg/kg (as syringetin glycoside) . Lower contents of O ‐methoxy flavonols were found in the white fig variety Bidhi, matching observations for white grape varieties …”

Section: Resultsmentioning

confidence: 99%

“…26 Lower contents of O-methoxy flavonols were found in the white fig variety Bidhi, matching observations for white grape varieties. 31,32 Isorhamnetin is a compound characterized by anti-inflammatory, antioxidant, and anticancer activity. 33,34 It also acts as a chemopreventive against cardiovascular and Alzheimer diseases.…”

Section: Non-anthocyanic Flavonoids Profile Of Fig Varietiesmentioning

confidence: 99%

See 1 more Smart Citation

LC‐QTOF characterization of non‐anthocyanic flavonoids in four Tunisian fig varieties

et al. 2018

View full text Add to dashboard Cite

Flavonoids are compounds characterized by antioxidant activity, and their intake in the human diet is considered useful for health and nutrition. Non-anthocyanic flavonoids in 4 different types of Tunisian figs belonging to the smyrna-type Ficus carica varieties known as Kholi, Tchich Asal, Himri, and Bidhi were studied by liquid chromatography/high-resolution mass spectrometry UHPLC-QqTOF. Twenty-two compounds belonging to the classes of flavanones (naringenin and eriodictyol), flavones (3 apigenin and 5 luteolin derivatives), and flavonols (2 kaempferol and 7 quercetin derivatives) were identified. Three O-methoxy flavonols (tamarixetin, syringetin, and isorhamnetin-3-O-glucoside) were found in figs for the first time. Total content of non-anthocyanic flavonoids found in dark varieties (between 410 and 830 mg/kg) show that these F. carica are fruits qualitatively and quantitatively rich of dietary polyphenols.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Non-anthocyanic Flavonoids Profile Of Fig Varietiesmentioning

confidence: 99%

LC‐QTOF characterization of non‐anthocyanic flavonoids in four Tunisian fig varieties

et al. 2018

View full text Add to dashboard Cite

show abstract

“…This analysis extensively applied the statistical and mathematical approach, mainly the multivariate methods. PCA is a relatively simple, nonparametric method for extracting relevant information from the dataset, identifying patterns in data, and expressing the data to highlight their similarities and differences (Singh et al 2013;Moraes et al 2016). In this study, PCA is used to analyze the correlation between responses such as physical properties of patch matrix (weight and thickness) and percentage of dissolution efficiency (%DE) of catechins, caffeine, and epigallocatechin gallate.…”

Section: Introductionmentioning

confidence: 99%

The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch

Setyawan¹,

Rohman²,

Setyowati³

et al. 2021

PHAR

View full text Add to dashboard Cite

Aim: This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods: The transdermal matrix patch formulation was optimized by the simplex lattice design method. The correlation between responses was analyzed using chemometrics. The observed responses were: 1. the physical properties of the matrix patch, and 2. the percentage of dissolution efficiency of catechins, caffeine, and epigallocatechin gallate released from the patch. The determination of drug release kinetics was based on the curve-fitting analysis using zero-order, first-order, Higuchi, and Korsmeyer-Peppas models. Results: The results showed that the optimal formula was obtained using the mixture of HPMC K100, HPMC K4M, and PEG 400 at a ratio of 4.0: 4.5: 0.5. The principal component analysis (PCA) showed that %DE300 values of catechin caffeine and epigallocatechin gallate positively correlate. A similar condition was observed between the weight and thickness of the matrix. Drug release kinetics follows the Korsmeyer-Peppas model.

show abstract

“…In fact, the use of alternative alcohols as solvents to extract phytochemicals from plants is limited to a few studies using ethylene glycol, propanediols, and glycerol. As can be seen in Table 1, the solvents most commonly applied, often mixed with water, were 1,2-propanediol [16][17][18][19][20][21][22][23][24][25] and glycerol [16,[25][26][27][28][29][30], and less frequently ethylene glycol [31].…”

Section: Introductionmentioning

confidence: 99%

“…Besides the aqueous solutions of alcohols, other combinations were also studied. Binary mixtures of ethanol + propylene glycol or glycerol were more effective than ethanol for the extraction of rosmarinic acid, carvacrol, oleanolic acid, and ursolic acid from three Origanun species by heat-assisted extractions (HAEs) [16], while higher amounts of isorhamnetin-3-O-rutinoside were extracted from Calendula officinalis L. flowers using an ethanol + propylene glycol + water equimolar mixture than using pure solvents or binary mixtures [17].…”

Section: Introductionmentioning

confidence: 99%

Insights on the Extraction Performance of Alkanediols and Glycerol: Using Juglans regia L. Leaves as a Source of Bioactive Compounds

et al. 2020

View full text Add to dashboard Cite

Glycerol and alkanediols are being studied as alternative solvents to extract phytochemicals from plant material, often as hydrogen bond donors in deep eutectic solvents (DESs). Many of those alcohols are liquid at room temperature, yet studies of their use as extraction solvents are scarce. In this work, glycerol and a series of alkanediols (1,2-ethanediol, 1,2-propanediol, 1,3-propanediol, 1,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, and 1,2-hexanediol) were studied for the extraction of phenolic compounds from Juglans regia L. leaves, a rich source of this class of bioactive compounds. The extraction yield was quantified, and the bioactivity of both extracts and pure solvents was evaluated by measuring the anti-inflammatory and cytotoxic activities. The solvents showing the best combined results were 1,2 and 1,3-propanediol, as their extracts presented a high amount of phenolic compounds, close to the results of ethanol, and similar cytotoxicity against cervical carcinoma cells, with no impact on non-tumor porcine liver cells in the studied concentration range. On the other hand, none of the extracts (and solvents) presented anti-inflammatory activity. Overall, the results obtained in this work contribute to the study of alternative solvents that could potentially be used also as formulation media, highlighting the importance of walnut leaves as a source of bioactive compounds.

show abstract

Optimization of chemometric approaches for the extraction of isorhamnetin-3-O-rutinoside from Calendula officinalis L.

Cited by 11 publications

References 18 publications

LC‐QTOF characterization of non‐anthocyanic flavonoids in four Tunisian fig varieties

LC‐QTOF characterization of non‐anthocyanic flavonoids in four Tunisian fig varieties

The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch

Insights on the Extraction Performance of Alkanediols and Glycerol: Using Juglans regia L. Leaves as a Source of Bioactive Compounds

Contact Info

Product

Resources

About