Optimization and characterization of pullulan produced by a newly identified strain of Aureobasidium pullulans

Haghighatpanah, Negar; Mirzaee, Homaira; Khodaiyan, Faramarz; Kennedy, John F.; Aghakhani, Ali; Hosseini, Seyed Saeid; Jahanbin, Kambiz

doi:10.1016/j.ijbiomac.2020.02.226

Cited by 69 publications

(28 citation statements)

References 36 publications

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“…Structurally, PUL consists mostly of repeating malto-triose units connected by α (1,4) and α (1,6) glycosidic bonds in a ratio of 2 to 1 [ 163 ] and it has been selected for the preparation of ultrathin electrospun nanofibers [ 164 ]. PUL is non-mutagenic, non-toxic, tasteless, and odorless and due to these characteristics, it has widespread use for different pharmaceutical and biomedical purposes [ 165 ]. In spite of its biocompatibility, skin tissue engineering applications of PUL are hindered by its high hydrophilicity, which limits the support for cellular attachment and proliferation, and which prevents the adsorption of proteins.…”

Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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Currently, despite the thoroughgoing scientific research carried out in the area of wound healing management, the treatment of skin injuries, regardless of etiology remains a big provocation for health care professionals. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, should also maintain a humid medium at the wound interfacing, and be easily removed without trauma. For the development of functional and bioactive dressings, they must meet different conditions such as: The ability to remove excess exudates, to allow gaseous interchange, to behave as a barrier to microbes and to external physical or chemical aggressions, and at the same time to have the capacity of promoting the process of healing by stimulating other intricate processes such as differentiation, cell adhesion, and proliferation. Over the past several years, various types of wound dressings including hydrogels, hydrocolloids, films, foams, sponges, and micro/nanofibers have been formulated, and among them, the electrospun nanofibrous mats received an increased interest from researchers due to the numerous advantages and their intrinsic properties. The drug-embedded nanofibers are the potential candidates for wound dressing application by virtue of: Superior surface area-to volume ratio, enormous porosity (can allow oxy-permeability) or reticular nano-porosity (can inhibit the microorganisms’adhesion), structural similitude to the skin extracellular matrix, and progressive electrospinning methodology, which promotes a prolonged drug release. The reason that we chose to review the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration. In this review, we have extensively discussed the recent advancements performed on electrospun nanofibers (eNFs) formulation methodology as wound dressings, and we focused as well on the entrapment of different active biomolecules that have been incorporated on polysaccharides-based nanofibers, highlighting those bioagents capable of improving the healing process. In addition, in vivo tests performed to support their increased efficacy were also listed, and the advantages of the polysaccharide nanofiber-based wound dressings compared to the traditional ones were emphasized.

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Section: Electrospun Nanofibers In Wound Healingmentioning

confidence: 99%

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

et al. 2020

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“…In the same spectrum, the peaks at 1637 and 1520 cm −1 corresponding to amide group I and to amide group II [43], could be attributed to the stretching of the carbonyl group -CO and to the symmetric stretching of N-CO bonds, respectively. Pullulan showed its characteristic bands located at 3268 (O-H), 2919 (C-H), 1637 (O-C-O) and 1394 cm −1 (C-O-H) [47] and a very sharp peak at 1054 cm −1 due to the stretching of the C-O-H bending vibration at the C-6 position [48], while its main characteristic peaks appeared to be the α-configuration of α-d-glucopyranose units at 845 cm −1 and the polysaccharide a(1,6) glycosidic linkage between glucose units at 931 cm −1 .…”

Section: Ftir Analysismentioning

confidence: 99%

“…stretching of the carbonyl group -CO and to the symmetric stretching of N-CO bonds, respectively. Pullulan showed its characteristic bands located at 3268 (O-H), 2919 (C-H), 1637 (O-C-O) and 1394 cm −1 (C-O-H) [47] and a very sharp peak at 1054 cm −1 due to the stretching of the C-O-H bending vibration at the C-6 position [48], while its main characteristic peaks appeared to be the αconfiguration of α-D-glucopyranose units at 845 cm −1 and the polysaccharide a(1,6) glycosidic linkage between glucose units at 931 cm −1 . In contrast to the plain ODFs, the FTIR spectra of the ISO-loaded ODFs demonstrated a peak at 1550 cm −1 attributed to amino group of ISO.…”

Section: Ftir Analysismentioning

confidence: 99%

Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

et al. 2020

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Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.

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“…Due to the high surface-to-volume ratio of nanoparticles, they have high reactivity to other materials; therefore, they have attracted much attention and have wide applications in the production of different goods. However, studies on nanoparticles have shown that some of them have negative effects on the growth and survival of creatures [ 21 , 22 ]. Nevertheless, there are various ambiguities about the toxicity mechanism of nanoparticles and, thus, recognizing these particles and their toxic effects is a necessity.…”

Section: Introductionmentioning

confidence: 99%

Migration of Various Nanoparticles into Food Samples: A Review

Paidari

Tahergorabi

Anari

et al. 2021

Foods

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Nanotechnology has provided new opportunities for the food industry with its applications in food packaging. The addition of nanoparticles, such as clay, silver and copper, can improve the mechanical and antimicrobial properties of food packaging. However, nanoparticles may have an adverse impact on human health. This has led to legislative and regulatory concerns. The inhibitory effects of nano packaging on different microorganisms, such as Salmonella, E. coli, and molds, have been studied. Nanoparticles, like other materials, may have a diverse set of properties that need to be determined. In this review, different features of silver, clay and copper nanoparticles, such as their anti-microbial, cell toxicity, genetic toxicity, mechanical properties, and migration, are critically evaluated in the case of food packaging. Specifically, the viewpoints of WHO, FDA, and ESFA, concerning the nano-silver application in food packaging, are discussed as well.

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Optimization and characterization of pullulan produced by a newly identified strain of Aureobasidium pullulans

Cited by 69 publications

References 36 publications

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management

Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

Migration of Various Nanoparticles into Food Samples: A Review

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