Electrospun Orodispersible Films of Isoniazid for Pediatric Tuberculosis Treatment

Abstract

Child-appropriate dosage forms are critical in promoting adherence and effective pharmacotherapy in pediatric patients, especially those undergoing long-term treatment in low-resource settings. The present study aimed to develop orodispersible films (ODFs) for isoniazid administration to children exposed to tuberculosis. The ODFs were produced from the aqueous solutions of natural and semi-synthetic polymer blends using electrospinning. The spinning solutions and the resulting fibers were physicochemically characterized, and the disintegration time and isoniazid release from the ODFs were assessed in simulated salivary fluid. The ODFs comprised of nanofibers with adequate thermal stability and possible drug amorphization. Film disintegration occurred instantly upon contact with simulated salivary fluid within less than 15 s, and isoniazid release from the ODFs in the same medium followed after the disintegration profiles, achieving rapid and total drug release within less than 60 s. The ease of administration and favorable drug loading and release properties of the ODFs may provide a dosage form able to facilitate proper adherence to treatment within the pediatric patient population.

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

“…The fibers produced by 5% PCL solution are narrower than those produced by 10% PCL solution. It has been well reported that the nanofibers produced by electrospinning enlarge with the increase of polymer concentration used for synthesis [ 11 , 12 , 13 ].…”

“…If the thickness, hydrophobicity and molecular interaction of fibers and transporting molecules can be a tool to impact release, would the fiber diameter and pore size be another tool to manipulate the release? It has been well reported that the fiber diameter produced by electrospinning can be reduced by decreasing the polymer concentration used for synthesis process [ 11 , 12 , 13 ]. It was also reported in microfiltration that the flux of molecules can be altered by changing the microstructure of the nanofiber membranes such as the fiber diameter and porosity [ 14 ].…”

Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride

“…Secondly, it can be used in the case of swallowing problems, such as Parkinson’s disease, stroke, multiple sclerosis, esophagitis, and allergies [ 4 , 5 ]. In geriatrics and pediatrics, it can play a huge role due to its easy and unnoticed application, so patients prefer this dosage form to per os tablets [ 6 , 7 ]. It is a useful form of drug administration from the chemical perspective, because the API and gastric acid do not contact each other, so the stomach can be protected from the API and vice versa [ 8 , 9 ].…”

Nanopartículas como transportadores de fármacos: una herramienta prometedora contra la tuberculosis

“…El uso de nanofibras para el tratamiento de la TB u otras micobacteriosis es un campo fértil de investigación, se han incorporado fármacos como estreptomicina, isoniacida, pirazinamida y claritromicina con resultados variables (53) . Sin embargo, unas películas diseñadas para la administración oral de isoniacida demostraron una alta eficiencia de desintegración, liberación y encapsulamiento del fármaco (54) . La utilización de nanofibras también se ha propuesto en la innovación de las técnicas de diagnóstico de TB, por ejemplo, se han preparado nanofibras como biosensores electroquímicos para la detección de ADN de Mycobacterium tuberculosis, las nanofibras resultantes presentaron una alta sensibilidad de detección (55) .…”