WWW home page: http://www.tima.imag.fr/cis in gates and wires (except for some particular wires). Such asynchronous circuits offer high robustness but do not perform well to automatically synthesize and optimize. This paper presents a new methodology to model and synthesize data path QDI circuits. The model used to represent circuits is based on Multi-valued Decision Diagrams and allows obtaining QDI circuits with two-input gates. Optimization is achieved by applying a technology mapping algorithm with a library of asynchronous standard cells called TAL. This work is a part of the back-end of our synthesis flow from high level language. Throughout the paper, a digit-slice radix 4 ALU is used as an example to illustrate the methodology and show the results.