Optimal antidotal dose of activated charcoal

Chin, Lincoln; Picchioni, Albert L.; Bourn, W.M.; Laird, Hugh E.

doi:10.1016/0041-008x(73)90090-2

Cited by 49 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A few studies have tried to answer this question either in experimental animals or in man. However, for obvious reasons the human studies have been made using relatively small doses of charcoal and drugs (Levy & Tsuchiya, 1972;Chin et al, 1973;Levy & Houston, 1976; The adsorption of PAS to activated charcoal was studied in vitro at pH 1.2 (0.1 M HCl) and pH 7.0 (0.05 M phosphate buffer) using charcoal-PAS ratios from 20:1 to 1:1. The incubations were performed at 37°C for 20 min as described earlier .…”

Section: Introduction Methodsmentioning

confidence: 99%

Effect of charcoal‐drug ratio on antidotal efficacy of oral activated charcoal in man.

Olkkola¹

1985

Brit J Clinical Pharma

View full text Add to dashboard Cite

The effect of charcoal‐drug ratio on the antidotal efficacy of oral activated charcoal was studied in six healthy volunteers in a randomized cross‐over study and compared with the adsorption capacity of activated charcoal in vitro. Aminosalicylic acid (PAS) 1 g and 5 g were ingested on an empty stomach in 30 ml of water. Immediately afterwards the subjects ingested 50 g of activated charcoal in 300 ml of water or 300 ml of water only. PAS 10 g 20 g were only given with 50 g of activated charcoal administered immediately afterwards. The plasma concentrations and the cumulative excretion of PAS into urine were measured for 48 h. Increasing the dose of PAS from 1 g to 20 g reduced the antidotal efficacy of activated charcoal: at a charcoal‐drug ratio of 50:1 under 5% of the dose was absorbed but at a ratio of 2.5:1 about 37%. These data correlated well to the saturation of adsorption capacity of charcoal in vitro. To minimize the possibility of saturation of the adsorption capacity of charcoal in acute intoxications where the amount and type of drug taken is usually unknown, large doses (50‐100 g) of activated charcoal should be used.

show abstract

Section: Introduction Methodsmentioning

confidence: 99%

Effect of charcoal‐drug ratio on antidotal efficacy of oral activated charcoal in man.

Olkkola¹

1985

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…The reduction in peak plasma concentrations and availability was not as great as has been observed for other drugs (Crome, Dawling, Braithwaite, Masters & Walkey, 1977) because soluble aspirin is absorbed relatively rapidly. It is possible that the administration of a larger or earlier dose of charcoal would have reduced the absorption of aspirin further but the 10:1 charcoal to drug ratio we used is regarded as optimal (Chin, Picchioni, Bourn & Laird, 1973). Both effervescent charcoal ('Medicoal') and the standard laboratory preparation ('Norit-A') appeared to be suitable for the emergency treatment of aspirin poisoning although the latter product will loose some of its efficacy if not stored in an air-tight container.…”

Section: Methodsmentioning

confidence: 99%

In Vitro and In Vivo Evaluation of Two Preparations of Activated Charcoal as Adsorbents of Aspirin

et al. 1983

View full text Add to dashboard Cite

1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound. 2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A'). 3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P < 0.001). 4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo.

show abstract

“…16 The effectiveness of charcoal depends on the dose and type of charcoal administered, the time of charcoal adminis¬ tration after poison ingestion, and the presence of compet¬ ing substances. The optimal dose of activated charcoal to administer to patients to prevent drug and poison absorp¬ tion is not known.…”

Section: Prevention Of Poison Absorptionmentioning

confidence: 99%

Expanded Role of Charcoal Therapy in the Poisoned and Overdosed Patient

Park¹

1986

Arch Intern Med

View full text Add to dashboard Cite

Optimal antidotal dose of activated charcoal

Cited by 49 publications

References 16 publications

Effect of charcoal‐drug ratio on antidotal efficacy of oral activated charcoal in man.

Effect of charcoal‐drug ratio on antidotal efficacy of oral activated charcoal in man.

In Vitro and In Vivo Evaluation of Two Preparations of Activated Charcoal as Adsorbents of Aspirin

Expanded Role of Charcoal Therapy in the Poisoned and Overdosed Patient

Contact Info

Product

Resources

About