In Vitro and In Vivo Evaluation of Two Preparations of Activated Charcoal as Adsorbents of Aspirin

Abstract

<jats:p> 1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound. </jats:p><jats:p> 2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A'). </jats:p><jats:p> 3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P &lt; 0.001). </jats:p><jats:p> 4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo. </jats:p>

In Vitro Adsorption Studies of Paracetamol to Activated Charcoal Capsule, Powder and Suspension

“…Several in vitro studies investigate the adsorption capacity of different test substances to AC [9][10][11][13][14][15][16][17]. In this study, it is found that pH had no effect on the adsorption capacity.…”

“…These three formulations contain AC with same surface area 1600 m 2 /g. The previous studies [9][10][11][12] have shown that there is a difference in adsorption capacity with different formulations of AC. Also, only the unionized form of drug is adsorbed.…”

Activated charcoal for acute overdose: a reappraisal

“…These studies employed varying doses of SDAC (0.5–100 g) at intervals of up to 6 h following ingestion of paracetamol , acetylsalicylic acid and other anti‐inflammatory agents , valproate and calcium channel blockers , among others. Of 122 total comparisons, 84 (69%) involved the administration of SDAC within 5 min of drug ingestion, demonstrating a mean reduction in absorption of 74%.…”