Optically tunable fluorescent carbon nanoparticles and their application in fluorometric sensing of copper ions

Lan, Minhuan; Zhao, Shaojing; Wu, Shuilin; Wei, Xiaofang; Fu, Yanzhao; Wu, Juanjuan; Wang, Pengfei; Zhang, Wenjun

doi:10.1007/s12274-019-2489-2

Cited by 48 publications

(21 citation statements)

References 46 publications

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“…The fluorescence quantum yield of the N,S-CDs aqueous solution (pH 7) was calculated to be 2.5%. The Stokes shift of the N,S-CDs was ∼215 nm, which was larger than that of organic dyes. , This large Stokes shift could significantly enhance the bioimaging quantity through reducing the self-absorption and improving the signal-to-noise ratio of the CDs. , Previous studies revealed that CDs are sensitive to metal ions or biomolecules. − However, our results revealed that these interferences have little effect on the fluorescence of the N,S-CDs (Figure S8). The surface groups on CDs, such as hydroxyl, carboxyl, and amino groups and S atoms, can have a certain coupling effect with many metal ions.…”

Section: Resultsmentioning

confidence: 53%

Polythiophene-Based Carbon Dots for Imaging-Guided Photodynamic Therapy

Zhao

Yang

Jiang

et al. 2021

ACS Appl. Nano Mater.

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Imaging-guided photodynamic therapy (PDT) represents an advantage in cancer therapy because of its optically controlled selectivity, negligible side effects, and ability to monitor the therapeutic effect in situ in real time. However, the photosensitizers currently in use have poor water solubility and an inability to target tumors, whereas semiconductor quantum dots and metal-based complexes that have excellent water dispersity have the disadvantage of exerting a potential toxicity because of the heavy metals. Therefore, this work describes the preparation of the red fluorescent N,S-doped carbon dots (N,S-CDs) from a polythiophene derivate that generate singlet oxygen ( 1 O 2 ) with a quantum yield of ∼8% under light irradiation. Moreover, these CDs possess the ability to penetrate tumor cells and mainly accumulate into the lysosome and mitochondria, as well as excellent biocompatibility, chemostability, and a large Stokes shift (215 nm). Hence, the N,S-CDs may be used as a potential effective photosensitizer for imaging-guided PDT.

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Section: Resultsmentioning

confidence: 53%

Polythiophene-Based Carbon Dots for Imaging-Guided Photodynamic Therapy

Zhao

Yang

Jiang

et al. 2021

ACS Appl. Nano Mater.

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“…The characteristic absorption bands of CDs at around 380 and 540 nm as well as typical absorbance peaks of Ce6 at 405 and 640 nm can all be found in the spectrum of Cu/CC NPs, this not only confirming the formation of assembles with reserved absorption properties of CDs and Ce6, but also revealing potentials of the assemblies for NIR‐light‐triggered photothermal imaging and therapy [20] . Interestingly, the FL of CDs‐Ce6 at optimal emission channel of CDs ( λ ex =550 nm) and Ce6 ( λ ex =405 nm) are dramatically quenched when assembled into Cu/CC NPs (Figure 1 i; Supporting Information, Figure S5), which is mainly ascribed to the Cu 2+ induced aggregation of CDs‐Ce6 and the electron/energy transfer processes [13a, 21] . This phenomenon also indicates that the FL imaging and photosensitization functions of CDs‐Ce6 in the nanoassemblies are in quenched state under neutral condition.…”

Section: Resultsmentioning

confidence: 57%

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu²⁺ Nanoassemblies

Sun,

Chen,

Tang

et al. 2020

Angew Chem Int Ed

261

174

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A method is developed to fabricate tumor microenvironment (TME) stimuli‐responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer (chlorine e6, Ce6) modified carbon dots (CDs‐Ce6) and Cu2+. The as‐obtained nanoassemblies (named Cu/CC nanoparticles, NPs) exhibit quenched FL and photosensitization due to the aggregation of CDs‐Ce6. Their FL imaging and photodynamic therapy (PDT) functions are recovered efficiently once they entering tumor sites by the stimulation of TME. Introducing of Cu2+ not only provides extra chemodynamic therapy (CDT) function through reaction with hydrogen peroxide (H2O2), but also depletes GSH in tumors by a redox reaction, thus amplifying the intracellular oxidative stress and enhancing the efficacy of reactive oxygen species (ROS) based therapy. Cu/CC NPs can act as a FL imaging guided trimodal synergistic cancer treatment agent by photothermal therapy (PTT), PDT, and thermally amplified CDT.

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“…The N 1s spectrum (Fig. 1e) shows two peaks at 399.6 and 401.5 eV that correspond to pyridinic and graphitic N, respectively [38]. The high-resolution S 2p spectrum revealed three peaks (164.0, 165.2, and 168.4 eV) that correspond to S 2p 3/2 and S 2p 1/2 of the thiophene S and oxidized S, respectively (Fig.…”

Section: Structural Characterization Of Mb-cdsmentioning

confidence: 96%

Photodynamic inheritance from methylene blue to carbon dots against reduction, aggregation, and DNA interference

et al. 2021

Sci. China Mater.

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Photodynamic therapy (PDT) is a treatment that uses light-sensitive drugs and a light source to destroy cancer cells. Methylene blue (MB) is an efficient photosensitizing agent that has been widely used in PDT. However, MB suffers from the hypochromic effect that is caused by self-aggregation and DNA binding in vivo. It is also easily reduced to ineffective leucomethylene blue in the hypoxic environments surrounding solid tumors. In this work, we prepared MB carbon dots (MB-CDs) using MB as the carbon source. The MB-CDs not only inherit the PDT capabilities of MB, but also demonstrate good biocompatibility and low toxicity. Importantly, MB-CDs demonstrate excellent resistance to interference from reduction, aggregation, and DNA interactions. The MB-CDs exhibited satisfactory PDT activities both in vitro and in vivo. The tumor sizes were reduced to below 20% of their original volumes when irradiated by a 590-nm lightemitting diode source.

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Optically tunable fluorescent carbon nanoparticles and their application in fluorometric sensing of copper ions

Cited by 48 publications

References 46 publications

Polythiophene-Based Carbon Dots for Imaging-Guided Photodynamic Therapy

Polythiophene-Based Carbon Dots for Imaging-Guided Photodynamic Therapy

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu²⁺ Nanoassemblies

Photodynamic inheritance from methylene blue to carbon dots against reduction, aggregation, and DNA interference

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Optically tunable fluorescent carbon nanoparticles and their application in fluorometric sensing of copper ions

Cited by 48 publications

References 46 publications

Polythiophene-Based Carbon Dots for Imaging-Guided Photodynamic Therapy

Polythiophene-Based Carbon Dots for Imaging-Guided Photodynamic Therapy

Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu2+ Nanoassemblies

Photodynamic inheritance from methylene blue to carbon dots against reduction, aggregation, and DNA interference

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Tumor Microenvironment Stimuli‐Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon‐Dot–Cu²⁺ Nanoassemblies