Optical techniques for the noninvasive diagnosis of skin cancer

Călin, Mihaela Antonina; Parasca, Sorin Viorel; Savastru, Roxana; Calin, Marian Romeo; Dontu, S.

doi:10.1007/s00432-013-1423-3

Cited by 108 publications

(72 citation statements)

References 71 publications

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“…51,52 In addition, the autofluorescence spectra of malignant tissues have usually very low intensity of fluorescence radiation emitted by endogenous fluorophores, above excitation of 300 nm. 3,15,34,36,53 Fluorescence is a highly promising and attractive technique for the diagnosis and demarcation of BCC. However, the multitude and the variability of clinical forms and fluorescence properties of benign and malignant skin lesions pose issues that limit its specificity.…”

Section: Optimizing Results: Processing and Interpretation Of Spectramentioning

confidence: 99%

“…15 Clinical studies have demonstrated that photosensitizer-induced skin fluorescence has significant diagnostic advantages compared with skin autofluorescence due to the increase in the fluorescence intensity by using exogenous fluorophores accumulating in the malignancy and the consequent better demarcation between the malignant and normal tissues ( Table 2).…”

Section: Lif: Basic Principles Made Simplementioning

confidence: 99%

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Laser-induced fluorescence made simple: implications for the diagnosis and follow-up monitoring of basal cell carcinoma

et al. 2014

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Abstract. Noninvasive treatments are increasingly being used for the management of basal cell carcinoma (BCC), the predominant type of nonmelanoma skin cancer, making the development of noninvasive diagnostic technologies highly relevant for clinical practice. Laser-induced fluorescence (LIF) spectroscopy emerges as an attractive diagnostic technique for the diagnosis and demarcation of BCC due to its noninvasiveness, high sensitivity, real-time measurements, and user-friendly methodology. LIF relies on the principle of differential fluorescence emission between abnormal and normal skin tissues (ex vivo and in vivo) in response to excitation by a specific wavelength of light. Fluorescence originates either from endogenous fluorophores (autofluorescence) or from exogenously administered fluorophores (photosensitizers). The measured optical properties and fluorophore contributions of normal skin and BCC are significantly different from each other and correlate well with tissue histology. Photodynamic diagnosis (PDD) is based on the visualization of a fluorophore, with the ability to accumulate in tumor tissue, by the use of fluorescence imaging. PDD may be used for detecting subclinical disease, determining surgical margins, and following-up patients for residual tumor or BCC relapse. In this review, we will present the basic principles of LIF and discuss its uses for the diagnosis, management, and follow-up of BCC.

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Section: Optimizing Results: Processing and Interpretation Of Spectramentioning

confidence: 99%

Section: Lif: Basic Principles Made Simplementioning

confidence: 99%

Laser-induced fluorescence made simple: implications for the diagnosis and follow-up monitoring of basal cell carcinoma

et al. 2014

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“…As a diagnostic tool, Raman spectroscopy is forging ahead in the cancer field providing a method by which to detect breast [25][26][27], skin [28,29], prostate [30][31][32], bladder [33][34][35], cervical [36][37][38], colorectal [39,40] and oesophageal cancer [41,42]. With bladder, [34,35] cervical, [37,38] colorectal [43] and oesophageal cancer [42] all being detected in vivo.…”

Section: Raman Spectroscopy and Ex Vivo/in Vivo Applications For The mentioning

confidence: 99%

Surface enhanced Raman spectroscopy (SERS): Potential applications for disease detection and treatment

McAughtrie

Faulds

Graham

2014

Journal of Photochemistry and Photobiology C: Photochemistry Re

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This version is available at https://strathprints.strath.ac.uk/49189/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the +44 (0) Highlights: A range of diseases can be detected by Raman and SERS in vitro, ex vivo and in vivo  In vivo multiplexed detection of cancer was achieved  SERS is also a key step in disease treatment  Studies must be further extended to a physiologically relevant medium and in vivo  The potential exists for the application of the techniques in a clinical setting

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“…Additional diagnostic techniques, such as videodermoscopy, ultrasonography or reflectance confocal microscopy usually are used after a preselection by the specialist or on the basis of dermoscopy examination. 6,7 The examination of all pigmented skin lesions, not only lesions preselected by the patient or the clinician is important for several reasons. Patients are usually concerned about palpable skin lesions, including seborrheic keratoses or dermatofibromas, and ignoring small, flat melanocytic lesions, which may be early melanomas.…”

Section: Dermoscopic Features In the Diagnosis Of Different Types Of mentioning

confidence: 99%

Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

Kardynał¹,

Olszewska

2014

J Dermatol Case Rep

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Over the past few years melanoma has grown into a disease of socio-economic importance due to the increasing incidence and persistently high mortality rates. Melanoma is a malignant tumor with a high tendency to metastasize. Therefore, an extremely important part of the therapeutic process is to identify the disease at an early stage: in situ or stage I. Many tools for early diagnosis of melanoma are available today, including dermoscopy, videodermoscopy and in vivo reflectance confocal microscopy. Other methods such as high frequency ultrasound, optical coherence tomography and electrical impedance spectroscopy may serve as additional diagnostic aids. Modern imaging techniques also allow the monitoring of melanocytic skin lesions over months or years to detect the moment of malignant transformation. This review summarizes the current knowledge about modern diagnostic techniques, which may aid early diagnosis of

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Optical techniques for the noninvasive diagnosis of skin cancer

Abstract: In conclusion, these optical techniques proved to be effective in the diagnosis of skin cancer, but further studies are needed in finding the appropriate method or combination of methods that can have wide clinical applications.

Cited by 108 publications

References 71 publications

Laser-induced fluorescence made simple: implications for the diagnosis and follow-up monitoring of basal cell carcinoma

Laser-induced fluorescence made simple: implications for the diagnosis and follow-up monitoring of basal cell carcinoma

Surface enhanced Raman spectroscopy (SERS): Potential applications for disease detection and treatment

Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

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