Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

Kardynał, Agnieszka; Olszewska, Małgorzata

doi:10.3315/jdcr.2014.1161

Cited by 52 publications

(40 citation statements)

References 39 publications

(52 reference statements)

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“…Melanin produces the strongest contrast (reflection index = 1.7). 3 The high magnification and resolution of RCM, coupled with the strong reflectivity of melanin, allow for the recognition of individual cells, such as melanocytes and pigmented keratinocytes. Melanin-containing histiocytes (melanophages) are also easily seen on RCM.…”

Section: Fundamentals Of Reflectance Confocal Microscopymentioning

confidence: 99%

Through the looking glass: Basics and principles of reflectance confocal microscopy

Que

Fraga‐Braghiroli

Grant‐Kels

et al. 2015

Journal of the American Academy of Dermatology

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Section: Fundamentals Of Reflectance Confocal Microscopymentioning

confidence: 99%

Through the looking glass: Basics and principles of reflectance confocal microscopy

Que

Fraga‐Braghiroli

Grant‐Kels

et al. 2015

Journal of the American Academy of Dermatology

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“…Dermoscopy might be utilized as an adjunctive tool in the in vivo examination of oral mucosal melanoma. 60,61 However a limiting factor is the accessibility of the lesion with a dermoscope. In our opinion, future technology R&D should focus on developing a miniaturized, flexible dermoscope that will allow detailed examination of the whole oral cavity.…”

Section: Resultsmentioning

confidence: 99%

Melanoma of the oral cavity: pathogenesis, dermoscopy, clinical features, staging and management

Warszawik-Hendzel

Słowińska²,

Olszewska

et al. 2014

J Dermatol Case Rep

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Primary mucosal melanoma of the oral cavity is an exceedingly rare neoplasm which is estimated to comprise 1-2% of all oral malignancies. In contrast to cutaneous melanomas, the risk factors and pathogenesis are poorly understood. The predominate localization of primary oral melanoma is hard palate and maxillary alveolus. Dermoscopy may be utilized as an adjunctive tool in the clinical differential diagnosis of oral mucosal melanoma whenever the lesion is accessible with a dermoscope. Surgery is the mainstay of treatment, but it may be challenging depending on the location of the tumor within the oral cavity and its size. Adjuvant therapy with dacarbazine, platinum analogs, nitrosoureas and interleukin-2 have been utilized with low response rates. Imatinib may be effective for patients with with c-Kit gene mutations. Sunitinib and dasatinib have been reported effective in selected cases. Vemurafenib and dabrafenib are targeted agents for patients with BRAF mutation-positive melanoma. Ipilimumab, an anti-cytotoxic T-lymphocyte antigen 4 antibody and pembrolizumab, a monoclonal antibody targeting programmed death 1 receptor may be a feasible treatment option in patients with metastatic mucosal melanoma. (J Dermatol Case Rep. 2014; 8(3) Melanoma is a malignant tumor that arises from melanocytes and is most commonly cutaneous in origin. Extracutaneous melanomas are known to be exceedingly rare and aggressive neoplasms that embrace ocular, mucosal and leptomeningeal melanomas. EpidemiologyMucosal melanomas are estimated to comprise 4-6.8 % of all primary melanomas. 1The incidence rate for mucosal melanoma (MM) is 2.3 per million. 1,2The incidence of MM increases with age. Older patients have tenfold higher incidence of MM compared to patients under the age of 60 years. 2Primary oral mucosal melanoma (POMM) is excessively uncommon in prepubertal children. 3Although there is a slight male preponderance (1.2:1), 1,4 some studies have been reported higher gender distribution of mucosal melanoma for women, 5,6 other indicate that there is no significant difference between sexes in the incidence of this tumor. 2,7The incidence rate of POMM is highest among Asian men. 3,6 Among the Japanese oral melanoma accounts for 7.5 % of all melanomas versus less than 1 % in Caucasians. 8,9Pathogenesis In contrast to cutaneous melanomas, the etiology and pathogenesis of POMM is poorly understood and no etiological and intraoral risk factors, other than preexisting pigmented nevi, have been identified. 10,11 POMM are believed to arise from pigmented nevi, pre-existing pigmented areas or de novo (30% cases) from apparently normal mucosa. 9,12 Although Kahn et al 13 described transformation of a benign oral pigmentation to primary oral melanoma, a definite precursor lesion has not been identified. 14,15 In the oral cavity, mechanical trauma including injury from ill-fitting prostheses, infection, tobacco use has been cited as possible causative factors, but its etiological role seems unlikely. 30Amelanotic oral melanoma is partic...

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“…Esta técnica ampliamente usada en la Dermatología Tradicional (Dermatoscopia clásica), permite evidenciar características morfológicas en su superficie de las lesiones pigmentadas que mejoran la aproximación diagnóstica. [6] Sin embargo, la técnica de Microscopía Epiluminiscente Clásica, resulta insuficiente como método, en la obtención de información sobre las estructuras internas y la profundidad. [3] Con el fin de mejorar la técnica se desarrolló un dispositivo que permitiera obtener un grupo de imágenes multiespectrales en el rango del visible.…”

Section: Materiales Y Métodosunclassified

“…Esto permite la visualización de las estructuras internas, proveyendo imágenes secuenciales en las diferentes bandas espectrales, dando origen a la Dermatoscopia Multiespectral [5,6].…”

Section: Introductionunclassified

Cutaneous Multispectral Optical tomography With ImageJ

Morales¹,

Toro²

2016

Opt. Pura Apl.

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ABSTRACT:The study of the optical properties of the skin has lead to the identification of the main chromophores such as hemoglobin and melanin. Melanin is a chromophore of the skin, whose accumulation in its different layers defines the types of melanocytic lesions (nevus). In order to achieve the reconstruction of acquired melanocytic lesions, the optic tomography of multispectral skin images was constructed by using a plugin created under the ImageJ environment. This plugin demonstrates the iconographic overlap of images, by capturing segmented images (by multispectral bands), called the multispectral cube of the skin. This 3D image allowed to verify the location of the main chromophores of each layer by its relation to the histopathological location. With this method, the melanin pigment localization patterns (melanin nests) were defined in real time and the structural alterations of nevic skin lesions, that would otherwise not be visible without biopsy, could be defined. The method we present has been shown very useful for for locating the chromophores of the skin.Key words: Multispectral, Skin, Photodiagnostic RESUMEN:Al estudiar las propiedades ópticas de la piel, se han identificado los principales cromóforos como son: la hemoglobina y la melanina. La melanina es un cromóforo de la piel, cuya acumulación en sus diferentes capas define los tipos de lesiones melanocíticas (nevus). Con la finalidad de lograr la reconstrucción de imágenes de lesiones melanocíticas adquiridas, se construyó la tomografía óptica de imágenes multiespectrales de piel mediante un plugin creado bajo el entorno ImageJ, que demuestra el solapamiento iconográfico de imágenes, mediante captura de imágenes segmentadas (por bandas multiespectrales), llamado cubo multiespectral de la piel. Esta imagen 3D permitió verificar la localización de los principales cromóforos de cada capa de la misma, al relacionarlas con la localización histopatológica. Con este método se definieron los patrones de ubicación de pigmento melánico (tecas de melanina), en tiempo real y se pudieron definir las alteraciones estructurales de lesiones névicas de piel que de otra forma no serían visibles, sin la toma de la biopsia. Este método se ha demostrado de gran utilidad para la localización de los cromóforos de la piel.

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Modern non-invasive diagnostic techniques in the detection of early cutaneous melanoma

Cited by 52 publications

References 39 publications

Through the looking glass: Basics and principles of reflectance confocal microscopy

Through the looking glass: Basics and principles of reflectance confocal microscopy

Melanoma of the oral cavity: pathogenesis, dermoscopy, clinical features, staging and management

Cutaneous Multispectral Optical tomography With ImageJ

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