Surface enhanced Raman spectroscopy (SERS): Potential applications for disease detection and treatment

McAughtrie, Sarah; Faulds, Karen; Graham, Duncan

doi:10.1016/j.jphotochemrev.2014.09.002

Cited by 77 publications

(40 citation statements)

References 122 publications

(211 reference statements)

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“…A great selection of reviews exist which go into further detail than is presented here for other related areas within SERS. These reviews include general overviews [267][268][269][270][271], and reviews specific to cell studies [272][273][274][275], medical applications [24,25,276,277], and toxicology [278,279].…”

Section: Surface-enhanced Raman Scattering (Sers)mentioning

confidence: 99%

See 1 more Smart Citation

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

228

167

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Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine.It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. These energy shifts can be used to obtain information regarding molecular composition of the sample with very high accuracy. Applications of Raman spectroscopy in the life sciences have included quantification of biomolecules, hyperspectral molecular imaging of cells and tissue, medical diagnosis, and others. This review briefly presents the physical origin of Raman scattering explaining the key classical and quantum mechanical concepts. Variations of the Raman effect will also be considered, including resonance, coherent, and enhanced Raman scattering. We discuss the molecular origins of prominent bands often found in the Raman spectra of biological samples. Finally, we examine several variations of Raman spectroscopy techniques in practice, looking at their applications, strengths, and challenges. This review is intended to be a starting resource for scientists new to Raman spectroscopy, providing theoretical background and practical examples as the foundation for further study and exploration.

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Section: Surface-enhanced Raman Scattering (Sers)mentioning

confidence: 99%

“…The low Raman scattering signal also limits the technique's ability to detect small concentrations of molecules. Surface enhanced Raman scattering (SERS) uses a metal substrate to enhance the Raman signal, making even trace amounts of molecules detectable [24,25].…”

Section: Introductionmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

228

167

View full text Add to dashboard Cite

show abstract

“…There is a growing interest for the application of surfaceenhanced Raman scattering (SERS) in diagnostics [13][14][15][16][17]. In this technique, detection is achieved upon adsorption of the analytes of interest onto a nanostructured metal surface (i.e., a SERS substrate) having adequate plasmonic properties, followed by illumination with a laser light, and analysis of its inelastic scattering using a spectrograph.…”

Section: Introductionmentioning

confidence: 99%

SERS analysis of serum for detection of early and locally advanced breast cancer

et al. 2015

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In this contribution, we investigated whether surface-enhanced Raman scattering (SERS) of serum can be a candidate method for detecting "luminal A" breast cancer (BC) at different stages. We selected three groups of participants aged over 50 years: 20 healthy women, 20 women with early localized small BC, and 20 women affected by BC with lymph node involvement. SERS revealed clear spectral differences between these three groups. A predictive model using principal component analysis (PCA) and linear discriminant analysis (LDA) was developed based on spectral data, and its performance was estimated with cross-validation. PCA-LDA of SERS spectra could distinguish healthy from BC subjects (sensitivity, 92 %; specificity, 85 %), as well as subjects with BC at different stages, with a promising diagnostic performance (sensitivity and specificity, ≥80 %; overall accuracy, 84 %). Our data suggest that SERS spectroscopy of serum, combined with multivariate data analysis, represents a minimally invasive, easy to use, and fast approach to discriminate healthy from BC subjects and even to distinguish BC at different clinical stages.

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“…17 The theoretical basis for the underlying phenomenon is well-known and established with quantum electrodynamical techniques offering a particularly insightful means of formulation. 18 The concurrent annihilation and creation of a photon of two different radiation modes is involved, typically entailing some exchange in vibrational energy with the system and thereby corresponding to an inelastic process.…”

Section: Introductionmentioning

confidence: 99%

Raman scattering mediated by neighboring molecules

Williams

Andrews

2016

The Journal of Chemical Physics

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Raman scattering is most commonly associated with a change in vibrational state within individual molecules, the corresponding frequency shift in the scattered light affording a key way of identifying material structures. In theories where both matter and light are treated quantum mechanically, the fundamental scattering process is represented as the concurrent annihilation of a photon from one radiation mode and creation of another in a different mode. Developing this quantum electrodynamical formulation, the focus of the present work is on the spectroscopic consequences of electrodynamic coupling between neighboring molecules or other kinds of optical center. To encompass these nanoscale interactions, through which the molecular states evolve under the dual influence of the input light and local fields, this work identifies and determines two major mechanisms for each of which different selection rules apply. The constituent optical centers are considered to be chemically different and held in a fixed orientation with respect to each other, either as two components of a larger molecule or a molecular assembly that can undergo free rotation in a fluid medium or as parts of a larger, solid material. The two centers are considered to be separated beyond wavefunction overlap but close enough together to fall within an optical near-field limit, which leads to high inverse power dependences on their local separation. In this investigation, individual centers undergo a Stokes transition, whilst each neighbor of a different species remains in its original electronic and vibrational state. Analogous principles are applicable for the anti-Stokes case. The analysis concludes by considering the experimental consequences of applying this spectroscopic interpretation to fluid media; explicitly, the selection rules and the impact of pressure on the radiant intensity of this process

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Surface enhanced Raman spectroscopy (SERS): Potential applications for disease detection and treatment

Cited by 77 publications

References 122 publications

Raman spectroscopy: techniques and applications in the life sciences

Raman spectroscopy: techniques and applications in the life sciences

SERS analysis of serum for detection of early and locally advanced breast cancer

Raman scattering mediated by neighboring molecules

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