Optical coherence tomography of the oval window niche

Just, Tino; Lankenau, Eva; Hüttmann, Gereon; Pau, Hans Wilhelm

doi:10.1017/s0022215109004381

Cited by 19 publications

(11 citation statements)

References 19 publications

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“…Recently, several successful feasibility studies on optical coherence tomography (OCT) in middle ear research, both ex vivo (Pitris et al 2001;Bibas et al 2004) and in vivo (Djalilian et al 2008;Just et al 2009;Nguyen et al 2012) have prompted us to conduct preliminary tests to measure full-field thickness variations of several rabbit and human TMs with OCT . Though successful, it was clear that additional hardware and software modifications to the measurement setup were required in order to measure full membranes.…”

Section: Introductionmentioning

confidence: 99%

Full-Field Thickness Distribution of Human Tympanic Membrane Obtained with Optical Coherence Tomography

Jeught

Dirckx

Aerts

et al. 2013

JARO

124

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The full-field thickness distribution, three-dimensional surface model and general morphological data of six human tympanic membranes are presented. Crosssectional images were taken perpendicular through the membranes using a high-resolution optical coherence tomography setup. Five normal membranes and one membrane containing a pathological site are included in this study. The thickness varies strongly across each membrane, and a great deal of interspecimen variability can be seen in the measurement results, though all membranes show similar features in their respective relative thickness distributions. Mean thickness values across the pars tensa ranged between 79 and 97 μm; all membranes were thinnest in the central region between umbo and annular ring (50-70 μm), and thickness increased steeply over a small distance to approximately 100-120 μm when moving from the central region either towards the peripheral rim of the pars tensa or towards the manubrium. Furthermore, a local thickening was noticed in the antero-inferior quadrant of the membranes, and a strong linear correlation was observed between inferior-posterior length and mean thickness of the membrane. These features were combined into a single three-dimensional model to form an averaged representation of the human tympanic membrane. 3D reconstruction of the pathological tympanic membrane shows a structural atrophy with retraction pocket in the inferior portion of the pars tensa. The change of form at the pathological site of the membrane corresponds well with the decreased thickness values that can be measured there.

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Section: Introductionmentioning

confidence: 99%

Full-Field Thickness Distribution of Human Tympanic Membrane Obtained with Optical Coherence Tomography

Jeught

Dirckx

Aerts

et al. 2013

JARO

124

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“…The use of OCT for surgical guidance is a recently explored concept in ophthalmology(Dayani et al , 2009) but has been used by other specialists to guide cochlear implantation,(Just et al , 2009b; Pau et al , 2007) biopsy site localization (Just et al , 2009a), and diagnosis of vocal fold lesions. (Vokes et al , 2008) Delivery systems such as hand-held and microscopic probes may enable surgical applications of OCT systems, so that a clinician can have access to cross-sectional information when performing ophthalmic surgery - as opposed to only pre- and post-operative structural data.…”

Section: Future Directionsmentioning

confidence: 99%

“…A separate study suggested OCT may be used to evaluate the oval window niche. (Just et al , 2009b) Vokes et al also developed a surgical microscope to enable non-contact imaging of the vocal folds, which they found may be applicable to the diagnosis of vocal fold lesions, apparent in OCT sections as a disruption of the basement membrane. (Vokes et al , 2008) Others have developed operating microscopes with integrated OCT systems and used them define a biopsy site so a resection can be precisely planned.…”

Section: Future Directionsmentioning

confidence: 99%

Three dimensional optical coherence tomography imaging: Advantages and advances

Gabriele

Wollstein

Ishikawa

et al. 2010

Progress in Retinal and Eye Research

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Three dimensional (3D) ophthalmic imaging using optical coherence tomography (OCT) has revolutionized assessment of the eye, the retina in particular. Recent technological improvements have made the acquisition of 3D-OCT datasets feasible. However, while volumetric data can improve disease diagnosis and follow-up, novel image analysis techniques are now necessary in order to process the dense 3D-OCT dataset. Fundamental software improvements include methods for correcting subject eye motion, segmenting structures or volumes of interest, extracting relevant data post hoc and signal averaging to improve delineation of retinal layers. In addition, innovative methods for image display, such as C-mode sectioning, provide a unique viewing perspective and may improve interpretation of OCT images of pathologic structures. While all of these methods are being developed, most remain in an immature state. This review describes the current status of 3D-OCT scanning and interpretation, and discusses the need for standardization of clinical protocols as well as the potential benefits of 3D-OCT scanning that could come when software methods for fully exploiting these rich data sets are available clinically. The implications of new image analysis approaches include improved reproducibility of measurements garnered from 3D-OCT, which may then help improve disease discrimination and progression detection. In addition, 3D-OCT offers the potential for preoperative surgical planning and intraoperative surgical guidance.

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“…Several studies concerning the structure and structural changes of the TM by applying OCT were carried out in the last years [8][9][10] and recently, Rutledge et al [11] describe imaging of the internal collagen fiber structures in the lamina propria of the TM with a spatial domain OCT system. The clinical usability of OCT was demonstrated by Djalilian et al [9] (in vivo inspection of the mucosa of the tympanic cavity in order to detect cholesteatoma), Heermann et al [12] (distance measurements for middle ear prosthesis), and Just et al [13] (in depth visualization of the oval window niche). A further important application area of OCT is the measurement of motions of a sample with phase-resolved Doppler analysis [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the human tympanic membrane oscillation ex vivo by Doppler optical coherence tomography

Burkhardt¹,

Kirsten²,

Bornitz

et al. 2012

Journal of Biophotonics

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Investigations of the tympanic membrane (TM) can have an important impact on understanding the sound conduction in the ear and can therefore support the diagnosis and treatment of diseases in the middle ear. High-speed Doppler optical coherence tomography (OCT) has the potential to describe the oscillatory behaviour of the TM surface in a phase-sensitive manner and additionally allows acquiring a three-dimensional image of the underlying structure. With repeated sound stimuli from 0.4 kHz to 6.4 kHz, the whole TM can be set in vibration and the spatially resolved frequency response functions (FRFs) of the tympanic membrane can be recorded. Typical points, such as the umbo or the manubrium of malleus, can be studied separately as well as the TM surface with all stationary and wave-like vibrations. Thus, the OCT methodology can be a promising technique to distinguish between normal and pathological TMs and support the differentiation between ossicular and membrane diseases.

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Optical coherence tomography of the oval window niche

Abstract: Investigation of the relatively new technology of optical coherence tomography indicated that this imaging modality may assist the ear surgeon to assess the oval window niche intra-operatively.

Cited by 19 publications

References 19 publications

Full-Field Thickness Distribution of Human Tympanic Membrane Obtained with Optical Coherence Tomography

Full-Field Thickness Distribution of Human Tympanic Membrane Obtained with Optical Coherence Tomography

Three dimensional optical coherence tomography imaging: Advantages and advances

Investigation of the human tympanic membrane oscillation ex vivo by Doppler optical coherence tomography

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