Three dimensional optical coherence tomography imaging: Advantages and advances

Abstract

Three dimensional (3D) ophthalmic imaging using optical coherence tomography (OCT) has revolutionized assessment of the eye, the retina in particular. Recent technological improvements have made the acquisition of 3D-OCT datasets feasible. However, while volumetric data can improve disease diagnosis and follow-up, novel image analysis techniques are now necessary in order to process the dense 3D-OCT dataset. Fundamental software improvements include methods for correcting subject eye motion, segmenting structures or volumes of interest, extracting relevant data post hoc and signal averaging to improve delineation of retinal layers. In addition, innovative methods for image display, such as C-mode sectioning, provide a unique viewing perspective and may improve interpretation of OCT images of pathologic structures. While all of these methods are being developed, most remain in an immature state. This review describes the current status of 3D-OCT scanning and interpretation, and discusses the need for standardization of clinical protocols as well as the potential benefits of 3D-OCT scanning that could come when software methods for fully exploiting these rich data sets are available clinically. The implications of new image analysis approaches include improved reproducibility of measurements garnered from 3D-OCT, which may then help improve disease discrimination and progression detection. In addition, 3D-OCT offers the potential for preoperative surgical planning and intraoperative surgical guidance.

Retinal surface imaging provided by Cirrus high-definition optical coherence tomography prominently visualizes a dissociated optic nerve fiber layer appearance after macular hole surgery

“…The latest version of the Cirrus high-definition OCT (HD-OCT) software (Carl Zeiss Meditec, Dublin, CA, USA) enables the reconstruction of a curved surface of the retina (retinal surface image) and permits better visualization of the innermost retinal surface theoretically. Therefore, it would be interesting to see if we can obtain clinically valuable information about the retinal surface with this OCT software [2][3][4][5].…”

Serum levels of lipid metabolites in age‐related macular degeneration

“…At its final stage, there are a reduced number of photoreceptor cells and cells in the retinal pigmented epithelium that are essential for photoreceptor function and survival. Imaging techniques such as Abbreviations: 5-HETE, 5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; 8-HETE, 8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid; 9-HETE, 9-hydroxy-5Z,7E,11Z,14Z-eicosatetraenoic; 9-HODE, 9-hydroxy-10E,12Z-octadecadienoic acid; 11-HETE, 11-hydroxy-5Z,8Z,12E,14Z-eicosatetraenoic acid; 12-HETE, 12-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid; 13-HODE, (continued on next page) scanning laser ophthalmoscopy and optical coherent tomography have revolutionized current ophthalmology, improving the diagnosis of retinal diseases, monitoring their progression, evaluating treatment options, and dramatically advancing in vivo retinal research (11)(12)(13)(14)(15)(16)(17). However, by the time structural changes are observed in the retina with current methodology, the pathology is already well established.…”

Volumetric quantification ofin vitrosonothrombolysis with microbubbles using high-resolution optical coherence tomography

“…OCT, which has the ability to visualize thrombus in vivo, 12 is gaining use in clinical practice and offers important potential advantages over current methods for assessment of sonothrombolysis owing to its ability to capture highresolution 3-D real-time volumetric images noninvasively with minimal sample manipulation. 11,13 To our knowledge, there has been no report to date assessing MB-mediated thrombolysis using OCT.…”