Optical coherence elastography reveals the changes in cardiac tissue biomechanical properties after myocardial infarction in a mouse model

Singh, Manmohan; Wang, Shang; Liu, Chih-Hao; Leach, John P.; Rippy, Justin; Larina, Irina V.; Martin, James F.; Larin, Kirill V.

doi:10.1117/12.2511524

Cited by 2 publications

(3 citation statements)

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“…The micro-air pulse delivers a localized impulse stimulus towards the surface of tissues in order to produce a wave perturbation. It was firstly proposed in [93,94], and since then, it has been applied to the generation of SAWs for the elastography of diverse tissues, including cornea [20,26,62,[95][96][97][98][99][100][101], skin [13,102,103], cardiac and skeletal muscles [104][105][106], and cartilages [107], to name just a few applications. Air-pulse stimulation has advantageous properties relevant for its clinical translation, including its non-contact coupling with tissues, the generation of small loading pressures (in the mPa range), and the precedent of being used safely in other screening devices in ophthalmology [108,109].…”

Section: Air-pulse Stimulationmentioning

confidence: 99%

“…Then, ARF was used for the elastography of tissues in different applications [34,153,173,182]. Air-pulse stimulation for the generation of short-duration and low-pressure waves was proposed in [94] as a pilot study in phantoms, and later on, it was applied for the elastography of ocular [20,26,62,[95][96][97][98][99][100][101], and other tissues [13,[102][103][104][105][106][107]. Finally, AC-ARF was proposed in [115] and explored in phantom studies, demonstrating the generation of non-contact (coupled with air), broadband, and localized stimulation of mechanical waves.…”

Section: Phantomsmentioning

confidence: 99%

“…The application of wave-based OCE has also been instrumental in the study of other ex vivo tissues, including skin elastography using air-pulse [103] and laser-based [113] stimulation; the study of cardiac tissues under normal conditions [104] and myocardial infarction [105,106], heart valves [189], uterus [190], liver [52,123], brain [76,191], cartilage [107], soft tumors [93], skeletal muscle [61], diaphragm muscle [24], and breast [192] tissues. Besides the study of ocular tissues, skin elastography has been of major interest in wave-based OCE since the imaging resolution of OCT implementations is capable of resolving tissue layers such as epidermis, dermis, and hypodermis with great detail compared to other imaging modalities.…”

Section: Other Tissuesmentioning

confidence: 99%

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Wave-based optical coherence elastography: the 10-year perspective

Zvietcovich

Larin

2022

Prog. Biomed. Eng.

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After ten years of progress and innovation, optical coherence elastography (OCE) based on the propagation of mechanical waves has become one of the major and, perhaps, one of the most studied OCE branches, producing a fundamental impact in the quantitative and nondestructive biomechanical characterization of tissues. Preceding previous progress made in ultrasound and magnetic resonance elastography; wave-based OCE has pushed to the limit the advance of three major pillars: (1) implementation of novel wave excitation methods in tissues, (2) understanding new types of mechanical waves in complex boundary conditions by proposing advance analytical and numerical models, and (3) the development of novel estimators capable of retrieving quantitative 2D/3D biomechanical information of tissues. This remarkable progress promoted a major advance in answering basic science questions and improving medical disease diagnosis and treatment monitoring in several types of tissues leading, ultimately, to the first attempts of clinical trials and translational research. This paper summarizes the fundamental up-to-date principles and categories of wave-based OCE, revises the timeline and the state-of-the-art techniques and applications lying in those categories, and concludes with a discussion of current challenges and future directions, including clinical translation research.

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