Reverberant Elastography for the Elastic Characterization of Anisotropic Tissues

Alemán-Castañeda, Luis A.; Zvietcovich, Fernando; Parker, Kevin J.

doi:10.1109/jstqe.2021.3069098

Cited by 10 publications

(7 citation statements)

References 26 publications

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“…The right side is also recognized as the second moment m s 2 of the power spectrum of the RSW field, which has been derived previously (Parker et al 2017, Zvietcovich et al 2019, Aleman-Castañeda et al 2021 and is strictly bandlimited to k .…”

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confidence: 97%

Reverberant shear wave phase gradients for elastography

Ormachea

Parker

2021

Phys. Med. Biol.

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Reverberant shear wave fields are produced when multiple sources and multiple reflections establish a complex three-dimensional wave field within an organ. The expected values are assumed to be isotropic across all directions and the autocorrelation functions for velocity are expressed in terms of spherical Bessel functions. These results provide the basis for adroit implementations of elastography from imaging systems that can map out the internal velocity or displacement of tissues during reverberant field excitations. By examining the phase distribution of the reverberant field, additional estimators can be derived. In particular, we demonstrate that the reverberant phase gradient is shown to be proportional to the local value of wavenumber. This phase estimator is less sensitive to imperfections in the reverberant field distribution and requires a smaller support window, relative to earlier estimators based on autocorrelation. Applications are shown in simulations, phantoms, and in vivo liver.

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confidence: 97%

Reverberant shear wave phase gradients for elastography

Ormachea

Parker

2021

Phys. Med. Biol.

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“…This technique stands out for its superior elasticity resolution when compared to the USE previously reported 11 and superior mechanical contrast compared to traditional wave-based OCE. 18 Furthermore, unlike conventional RevOCE methods that utilize mechanical shakers that physically contact tissues directly, which can potentially compromise the integrity of delicate tissues while inducing a reverberant field, 18 , 42 , 43 the presented technique relies on ARF, which does not necessitate direct contact between the actuator and the sample, making it more convenient for in vivo applications. By providing a more complete understanding of the interrelationship of the biomechanical properties of the different ocular components, this technique can have important implications for both research and clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Multifocal acoustic radiation force-based reverberant optical coherence elastography for evaluation of ocular globe biomechanical properties

Mekonnen,

Zevallos-Delgado,

Singh

et al. 2023

J. Biomed. Opt.

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Quantifying the biomechanical properties of the whole eye globe can provide a comprehensive understanding of the interactions among interconnected ocular components during dynamic physiological processes. By doing so, clinicians and researchers can gain valuable insights into the mechanisms underlying ocular diseases, such as glaucoma, and design interventions tailored to each patient's unique needs. Aim:The aim of this study was to evaluate the feasibility and effectiveness of a multifocal acoustic radiation force (ARF) based reverberant optical coherence elastography (RevOCE) technique for quantifying shear wave speeds in different ocular components simultaneously.Approach: We implemented a multifocal ARF technique to generate reverberant shear wave fields, which were then detected using phase-sensitive optical coherence tomography. A 3D-printed acoustic lens array was employed to manipulate a collimated ARF beam generated by an ultrasound transducer, producing multiple focused ARF beams on mouse eye globes ex vivo. RevOCE measurements were conducted using an excitation pulse train consisting of 10 cycles at 3 kHz, followed by data processing to produce a volumetric map of the shear wave speed. Results:The results show that the system can successfully generate reverberant shear wave fields in the eye globe, allowing for simultaneous estimation of shear wave speeds in various ocular components, including cornea, iris, lens, sclera, and retina. A comparative analysis revealed notable differences in wave speeds between different parts of the eye, for example, between the apical region of the cornea and the pupillary zone of the iris (p ¼ 0.003). Moreover, the study also revealed regional variations in the biomechanical properties of ocular components as evidenced by greater wave speeds near the apex of the cornea compared to its periphery. Conclusions:The study demonstrated the effectiveness of RevOCE based on a non-invasive multifocal ARF for assessing the biomechanical properties of the whole eyeball. The findings indicate the potential to provide a comprehensive understanding of the mechanical behavior of the whole eye, which could lead to improved diagnosis and treatment of ocular diseases.

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“…1) Anisotropy. Tissues including muscle and tendons and white matter contain oriented structures that can be modelled as a principal axis with significantly different material properties, stiffnesses, and shear wave speeds along vs. across the major axis [14]. Elastography can provide sensitive measures of these properties but at the cost of increased complexity of the scan and analyses.…”

Section: Discussionmentioning

confidence: 99%

The expanding frontier of optical elastography and diagnostic biomechanics

Parker

Rolland

et al. 2023

Optical Elastography and Tissue Biomechanics X

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The term "elastography" covers a dynamic and expanding set of diagnostic imaging techniques which probe the biomechanical properties of tissues. This overview covers some of the major approaches that have evolved and their role in improving clinical diagnoses. A deeper level of study is also emerging linking our estimates of viscoelasticity to the multiscale structure and composition of living tissue in normal and diseased states. These studies can be undertaken at the highest spatial resolution with optical techniques, and examples in cornea, brain, and skin will be covered.

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Reverberant Elastography for the Elastic Characterization of Anisotropic Tissues

Cited by 10 publications

References 26 publications

Reverberant shear wave phase gradients for elastography

Reverberant shear wave phase gradients for elastography

Multifocal acoustic radiation force-based reverberant optical coherence elastography for evaluation of ocular globe biomechanical properties

The expanding frontier of optical elastography and diagnostic biomechanics

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