Optic Neuropathy and Chronic Cyanide Intoxication: A Review

Freeman, A. G.

doi:10.1177/014107688808100219

Cited by 54 publications

(27 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another hypothesis is that some components of cigarette smoke (e.g. cyanide) may have direct toxic effects on the CNS [10] . Additionally, it has been assumed that tar and nicotine may be important immunotoxic components in cigarette smoke, since both the smoke itself and nicotine may impair antigen-mediated signaling in T cells [11,18] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lifestyle Factors and Multiple Sclerosis: A Case-Control Study in Belgrade

Pekmezović

Drulović²,

Milenkovic³

et al. 2006

Neuroepidemiology

View full text Add to dashboard Cite

The aim of this case-control study was to assess the risk of developing multiple sclerosis (MS) associated with certain lifestyle factors (cigarette smoking and coffee and alcohol consumption). The study groups consisted of 210 cases with clinically proven and/or laboratory-confirmed MS (Poser’s criteria) and an identical number of sex- and age-matched hospital controls. In the MS patients, cigarette smoking was significantly more frequent than in the controls (OR = 1.6, p = 0.021). A dose-response relationship between the risk of MS and both duration (years) of smoking (p = 0.027) and number of cigarettes smoked daily (p = 0.021) was observed. Coffee consumption was significantly more frequent in the MS group (OR = 1.7, p = 0.047), with dose-response relationships. The analysis of alcohol drinking showed a significant association between consumption of hard liquor per day and risk of MS (OR = 6.7, p = 0.026). In multivariate logistic regression analysis, smoking was detected to be a significant independent risk factor for MS (OR = 2.4, p = 0.004).

show abstract

Section: Discussionmentioning

confidence: 99%

“…4 ]. Experimental data suggest that some components of the cigarette smoke may have neurotoxic or immunomodulatory effects [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Lifestyle Factors and Multiple Sclerosis: A Case-Control Study in Belgrade

Pekmezović

Drulović²,

Milenkovic³

et al. 2006

Neuroepidemiology

View full text Add to dashboard Cite

show abstract

“…1.8.1.1], (ii) by direct chemical combination of cyanide with sulfur in the form of an amino acid (di-cysteine) with the formation of 2-aminothiazoline-4-carboxylic acid and cysteine; (iii) by combination of cyanide with hydroxycobalamin (in vivo or as a therapeutic expedient) to form cyanocobalamin (vitamin B12) (Askar and Morad, 1983;Ludewig and Lohs, 1975;Freeman, 1988;ATSDR, 2004 The enzyme rhodanase, which is usually localised in the mitochondria in different tissues, is relatively abundant, but in sites not readily accessible to thiosulfate. The limiting factor for the conversion of cyanide is thus thiosulfate (US EPA, 1990).…”

Section: Toxicokinetics Metabolism and Tissue Distribution Of Hcn Inmentioning

confidence: 99%

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to cyanogenic compounds as undesirable substances in animal feed

2007

EFSA Journal

View full text Add to dashboard Cite

SUMMARYHydrogen cyanide (HCN) is formed following the enzymatic hydrolysis of cyanogenic glycosides, which are produced as secondary metabolites by various plant species. In the intact plant these cyanogenic compounds are stored separated from hydrolytic enzymes. Crushing of plant materials either by technical processes or by chewing by animals obliterates this separation and initiates the enzymatic hydrolysis of cyanogenic compounds, resulting ultimately in the formation of HCN. Hydrolysis to release HCN can also be accomplished by microorganisms in the digestive tract.

show abstract

“…Por outro lado, há vários trabalhos na literatura, relatando que a exposição prolongada ao cianeto, em baixas concentrações, pode ocasionar quadros de toxicidade crônica. De fato, em humanos, foi comprovada a associação entre a exposição crônica ao cianeto na etiologia de alguns distúrbios neurológicos, tais como neuropatia atáxica tropical 7 , konzo 8 , neuropatia retrobular da anemia perniciosa 9 e atrofia óptica de Leber 10,11 . Na criação animal, a ingestão crônica do cianeto tem sido associado a diversas doenças, como a cistite e ataxia enzoótica, uma síndrome caracterizada pela presença de degeneração walleriana da substância branca da medula espinhal e de degeneração de pedúnculos cerebrais e cerebelares 12,13,14 .…”

Section: Introductionunclassified

Exposição cianídrica em suínos: uma abordagem dos parâmetros toxicocinéticos utilizando o tiocianato como biomarcador

Manzano

Souza

Górniak

2006

Braz. J. Vet. Res. Anim. Sci.

View full text Add to dashboard Cite

ResumoO objetivo do presente estudo foi verificar os efeitos sobre a cinética do cianeto, em suínos, em diferentes fases da vida, usando o tiocianato como biomarcador. Vinte e dois suínos, foram divididos em quatro grupos (60 dias da idade, 95 dias da idade, 80 dias do gestação e 21 dias de lactação), e receberam por via oral, a dose única de 3.0 mg /kg de peso vivo de cianeto do potássio (KCN

show abstract

Optic Neuropathy and Chronic Cyanide Intoxication: A Review

Cited by 54 publications

References 29 publications

Lifestyle Factors and Multiple Sclerosis: A Case-Control Study in Belgrade

Lifestyle Factors and Multiple Sclerosis: A Case-Control Study in Belgrade

Opinion of the Scientific Panel on contaminants in the food chain [CONTAM] related to cyanogenic compounds as undesirable substances in animal feed

Exposição cianídrica em suínos: uma abordagem dos parâmetros toxicocinéticos utilizando o tiocianato como biomarcador

Contact Info

Product

Resources

About