Exposição cianídrica em suínos: uma abordagem dos parâmetros toxicocinéticos utilizando o tiocianato como biomarcador

Manzano, Helena; Souza, Altamir Benedito de; Górniak, Silvana Lima

doi:10.11606/issn.1678-4456.bjvras.2006.26541

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…This procedure ensured that all females ingested the target doses of cyanide quickly (usually in less than 2 min) in each administration. In a previous study of toxicokinetics in pregnant sows, we verified that, following oral exposure to KCN, serum thiocyanate levels increase by 3 hrs, peak after 6 hrs, and remain elevated for up to 21 hrs [ 46 ]. Thus, we assumed that the administration of cyanide twice daily would ensure high serum levels of thiocyanate steadily, independently of the phase of pregnancy.…”

Section: Discussionmentioning

confidence: 56%

Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation

Gotardo

Hueza

Manzano

et al. 2015

Journal of Toxicology

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Cyanide is a ubiquitous chemical in the environment and has been associated with many intoxication episodes; however, little is known about its potentially toxic effects on development. The aim of this study was to evaluate the effects of maternal exposure to potassium cyanide (KCN) during pregnancy on both sows and their offspring. Twenty-four pregnant sows were allocated into four groups that orally received different doses of KCN (0.0, 2.0, 4.0, and 6.0 mg/kg of body weight) from day 21 of pregnancy to term. The KCN-treated sows showed histological lesions in the CNS, thyroid follicle enlargement, thyroid epithelial thickening, colloid reabsorption changes, and vacuolar degeneration of the renal tubular epithelium. Sows treated with 4.0 mg/kg KCN showed an increase in the number of dead piglets at birth. Weaned piglets from all KCN-treated groups showed histological lesions in the thyroid glands with features similar to those found in their mothers. The exposure of pregnant sows to cyanide thus caused toxic effects in both mothers and piglets. We suggest that swine can serve as a useful animal model to assess the neurological, goitrogenic, and reproductive effects of cyanide toxicosis.

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Section: Discussionmentioning

confidence: 56%

Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation

Gotardo

Hueza

Manzano

et al. 2015

Journal of Toxicology

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“…Segundo Manzano et al (2006), o produto da biotransformação do HCN, tiocianato, apresenta propriedade inibitória sobre a captação de iodo na glândula tireóide, o que resulta na diminuição da produção dos hormônios tireoideanos. Este mecanismo é mais relevante em casos de exposição crônica a doses mais baixas, uma vez que, as exposições mais elevadas afetam diretamente o sistema nervoso causando danos imediatos.…”

Section: Toxicodinâmica Do Hcnunclassified

Avaliação da exposição de trabalhadores de casas-de-farinha ao ácido cianídrico proveniente da mandioca, Manihot esculenta, Crantz, no agreste alagoano

Zacarias¹

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Exposure of cassava processing workers to hydrogen cyanide from Manihot esculenta, Crantz, in Alagoas, Brazil Cassava used for flour production contains high amounts of cyanogenic glycosides, compounds that, after degradation, release hydrogen cyanide (HCN) which provide toxicity to these type of root. A suitable cassava processing results in the degradation of cyanogenic glycosides and in the production of a safety flour for consumption as food, which generates the hypothesis of HCN release during the process. In this context, the present study aimed to evaluate the HCN exposure of workers engaged in cassava processing, as well as, to identify possible clinical and laboratory alterations related to this exposure. It was included in the study 4 cassava processing facilities placed on Alagoas state, Brazil. It was conducted the determination of HCN in air samples according to the method 6010 proposed by NIOSH. Each industry was monitored in three points: two on workers respiratory zone and one static. A total of 36 male volunteers, distributed between the 4 facilities were included in the study. Each participant was submitted to urine sampling, been one before and other after work shift, and to one blood sampling before work shift. Urinary thiocyanate (SCN-) was spectrophotometrically determined, whereas the remaining biochemical evaluation was conducted in a commercial clinical laboratory. The results indicated that the cassava processors are chronically exposed to HCN at levels between 0,464±0,02 and 3,328±3,85 mg/m³, in the work environment. The comparison between the levels determined at the present study with the Occupational Exposure Limits (OEL) established by NIOSH and ACGIH indicated that cassava processors may be exposed to HCN levels capable of causing adverse health effects. The mean levels of urinary thiocyanate (10,62-before shift and 8,76-after shift), were significantly higher than the reference value for non smokers and also for the history mean obtained from the laboratory employed for SCNanalysis, during 2008-2010. The results of laboratorial evaluation indicated increase in the serum activity of alkaline phosphatase in cassava processors exposed to HCN, with a prevalence of 93,3%. The workers were submitted to clinical evaluation and it was not detected any alteration typical of HCN exposure.

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Exposição cianídrica em suínos: uma abordagem dos parâmetros toxicocinéticos utilizando o tiocianato como biomarcador

Cited by 2 publications

References 19 publications

Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation

Intoxication by Cyanide in Pregnant Sows: Prenatal and Postnatal Evaluation

Avaliação da exposição de trabalhadores de casas-de-farinha ao ácido cianídrico proveniente da mandioca, Manihot esculenta, Crantz, no agreste alagoano

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