Optic neuritis associated with dideoxyinosine

Lafeuillade, Anne-Cécile; Aubert, L; Chaffanjon, P.; Quilichini, R

doi:10.1016/0140-6736(91)91682-k

Cited by 24 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,6 DDIR was first reported in children, 4 and later in adults. 7 Retinal lesions, studied more extensively in children, appear as areas of RPE mottling and atrophy in the midperiphery, which later become circumscribed by RPE hypertrophy.…”

Section: Commentmentioning

confidence: 99%

Didanosine-induced retinopathy in adults can be reversible

Fernando

Anderson

Holder

et al. 2006

Eye

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 99%

Didanosine-induced retinopathy in adults can be reversible

Fernando

Anderson

Holder

et al. 2006

Eye

View full text Add to dashboard Cite

“…Optic neuritis associated with didanosine in one patient was also reported [58]. Minor adverse effects observed [48] were irritability, anxiety, insomnia, headaches, transient abdominal pain, cardiac conduction abnormality in a patient with underlying cardiomyopathy, constipation, and rash [14].…”

Section: (5) 1992mentioning

confidence: 94%

Didanosine, a new antiretroviral drug

Franssen

Meenhorst

Koks

et al. 1992

Pharmaceutisch Weekblad Scientific Edition

View full text Add to dashboard Cite

In this article the literature about didanosine, an antiretroviral drug, is reviewed. The mechanism of action, biochemical pharmacology, pharmacokinetics, and clinical results of phase-I trials are discussed. Serious adverse effects such as pancreatitis and peripheral neuropathy have occurred in these trials. An antiretroviral effect was observed in terms of an increase in CD4+ lymphocytes and a decrease in p24 antigen levels in HIV-infected individuals. Didanosine seems to be a promising drug against HIV infection, but knowledge about its clinical efficacy is scanty.

show abstract

“…25·3 4 Ophthalmologic toxicity, including optic neuritis in adults and retinal atrophy in children, has been reported in at least two separate studies. 36 …”

Section: Ddl Constitutional and Miscellaneous Side Effectsmentioning

confidence: 97%

Adverse Effects

1992

Hospital Practice

View full text Add to dashboard Cite

show abstract

Optic neuritis associated with dideoxyinosine

Cited by 24 publications

References 3 publications

Didanosine-induced retinopathy in adults can be reversible

Didanosine-induced retinopathy in adults can be reversible

Didanosine, a new antiretroviral drug

Adverse Effects

Contact Info

Product

Resources

About