Adverse Effects

Ms, Saag

doi:10.1080/21548331.1992.11705597

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Inhibiting Hiv-1 Entry1

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1992

2001

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Cited by 13 publications

(1 citation statement)

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“…Patients who are more tolerant face expensive, arduous treatment. Among these patients, some harbor viral strains resistant to several drugs (128), and long-term adverse effects of treatment can develop (126,129,130). Also, because of increasing viral resistance, the threat of an outbreak of a virus immune to all available drugs is rising (128).…”

Section: Inhibiting Hiv-1 Entrymentioning

confidence: 99%

Mechanisms of Viral Membrane Fusion and Its Inhibition

Eckert

Kim²

2001

Annu. Rev. Biochem.

1,210

1,354

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Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.

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