Optic nerve head and fibre layer imaging for diagnosing glaucoma

Michelessi, Manuele; Lucenteforte, Ersilia; Oddone, Francesco; Brazzelli, Miriam; Parravano, Mariacristina; Franchi, Sara; Ng, Sueko M; Virgili, Gianni

doi:10.1002/14651858.cd008803.pub2

Cited by 74 publications

(87 citation statements)

References 148 publications

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“…The diagnosis of glaucoma is traditionally based on the finding of optic nerve head (ONH) damage assessed subjectively by ophthalmoscopy or photography or by corresponding damage to the visual field assessed by automated perimetry, or both [42]. The stereoscopic optic nerve head photograph is the most accurate method for papillary excavation quantification and common imaging devices outperform most clinicians in classifying optic discs [43].…”

Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy among Brazilian Xavante Indians

Lima

Franco

Fabbro

et al. 2018

Diabetol Metab Syndr

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BackgroundTo describe the frequency of diabetic retinopathy (DR) and its associated variables in Brazilian Xavante Indians.MethodsA population-based survey carried out in two Xavante Reservations between 2008 and 2012, included 948 Indians aged 20 years or more, identified 246 individuals with type 2 diabetes. A non-probabilistic cluster sample of 140 diabetic individuals were submitted to ophthalmologic examination. Due to operational conditions and to optimize the field work, only the larger Xavante villages were included. Ophthalmologic examinations were performed during one trip to each reservation, in their villages and consisted of measurement visual acuity, anterior segment biomicroscopy, applanation tonometry, and direct and indirect ophthalmoscopy.ResultsThe frequency of DR was 19.3%, distributed as follows: mild non-proliferative retinopathy in nine (33.3%) subjects, moderate in nine (33.3%), severe in six (22.3%), very severe in two (7.4%), and high-risk proliferative DR in one (3.7%). The occurrence of DR was higher among those with a longer duration of diabetes, higher levels of glycated hemoglobin (HbA1c) and fasting glucose, papillary excavation ≥ 0.5, and among individuals in older age group. Using the log-binomial regression model, diabetes duration > 24 months and HbA1c ≥ 6.5% were significantly associated with the occurrence of DR.ConclusionsThe presence of DR (19.3%) in Xavante Indians is an alert for health care providers for this population, since diabetes is a new disease among them. Its association with disease duration, high levels of HbA1c and blood glucose calls attention for the necessity of more actions to improve diabetes control in this recently contacted ethnic group that needs particular attention.

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Section: Discussionmentioning

confidence: 99%

Diabetic retinopathy among Brazilian Xavante Indians

Lima

Franco

Fabbro

et al. 2018

Diabetol Metab Syndr

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“…Since a large Cochrane review has shown that almost all studies on ONH and RNFL imaging tests for diagnosing glaucoma were case–control studies,10 only recently have large diagnostic studies been conducted that measure the accuracy of OCT in a cohort of prospectively enrolled subjects according to a single and well-defined question made in a screening14 or primary care referral11 12 setting. Different study designs and settings can lead to measuring different test performances.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study

et al. 2017

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Background/AimsTo assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting glaucoma.MethodsSecondary analyses of a prospective, multicentre diagnostic study (Glaucoma Automated Tests Evaluation (GATE)) referred to hospital eye services in the UK were conducted. We included data from 899 of 966 participants referred to hospital eye services with suspected glaucoma or ocular hypertension. We used both eyes’ data and logistic regression-based receiver operator characteristics analysis to build a set of models to measure the sensitivity and specificity of the average and inferior quadrant RNFL thickness data of OCT. The reference standard was expert clinician examination including automated perimetry. The main outcome measures were sensitivity at 0.95 specificity and specificity at 0.95 sensitivity and the corresponding RNFL thickness thresholds. We explored the possibility of accuracy improvement by adding measures of within-eye and between-eye variation, scan quality, intraocular pressure (IOP) and age.ResultsGlaucoma was diagnosed in at least one eye in 17% of participants. Areas under the curve were between 0.83 and 0.88. When specificity was fixed at 0.95, the sensitivity was between 0.38 and 0.55, and the highest values were reached with models including the inferior quadrant rather than the average RNFL thickness. Fixing sensitivity at 0.95, the specificity was between 0.36 and 0.58. The addition of age, refractive error, IOP or within-subject variation did not improve the accuracy.ConclusionRNFL thickness data of OCT can be used as a diagnostic test, but accuracy estimates remain moderate even in exploratory multivariable modelling of aiming to improve accuracy.

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“…Так, программа ОСТ автоматически рассчи-тывает контуры диска зрительного нерва по отноше-нию к склеральному кольцу Эльшнига, а программа HRT отдает эту функцию оператору-офтальмологу, который определяет границы диска зрительного нерва мануально. Поэтому нельзя проводить сравне-ние полученных данных и следует отдать предпочте-ние одному из этих методов [25,26]. Однако, по данным недавно проведенного метаанализа, высоко-спектральная OCT диска зрительного нерва обладает более высокой информативностью по сравнению с HRT [23].…”

Section: оптическая когерентная томография сетчатки и гейдельбергскаяunclassified

New opportunities in endocrine ophthalmopathy diagnostics (review)

et al. 2017

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Эндокринная офтальмопатия (ЭОП) -аутоим-мунное заболевание орбиты, которое характеризует-ся прогрессирующим иммуномедиаторным воспале-нием ретробульбарной клетчатки и экстраокулярных мышц [1]. Особенностью ЭОП является выраженная взаимосвязь аутоиммунного поражения структур орби ты с аналогичными заболеваниями щитовидной железы (диффузный токсический зоб (болезнь Грейвса), аутоиммунный тиреоидит) на фоне нару-шенного тиреоидного статуса [1,2]. При этом в 1,5-18,5% случаев ЭОП возникает на фоне эутиреоид-ного состояния (эутиреоидная ЭОП) [1,3] Эндокринная офтальмопатия (ЭОП) -это прогрессирующее аутоиммунное заболевание, поражающее ретробульбарные мягкие ткани на фоне заболеваний щитовидной железы. Представлена статистическая информация по данному заболе-ванию. В обзоре рассматриваются как общепринятые, так и альтернативные подходы к диагностике разных стадий ЭОП. Дана подробная клиническая симптоматика, основные классификации определения степени тяжести и активности ЭОП, необходимый перечень физикальных и инструментальных обследований. Описана диагностическая ценность ком-пьютерной томографии, магнитно-резонансной томографии, оптической когерентной томографии, Гейдельбергской ретинальной томографии, радиоизотопных исследований, триплексного сканирования магистральных сосудов глаза, метода допплеровского картирования, индоцианин-зеленой ангиографии, а также гистологического исследования био-птатов мягких ретробульбарных тканей при ЭОП. Общепринятые методы диагностики ЭОП имеют свои недостатки. Поэтому в настоящее время перспективным направлением являются иммунологические, биохимические и генетические исследования маркеров активности ЭОП. Особенностями данных методов в диагностике ЭОП являются точность, воз-можность многократного измерения, минимум побочных эффектов, а также относительно низкая стоимость. Отмечена важность дальнейшего изучения ключевых механизмов развития отека, лейкоцитарной инфильтрации с последующим формированием фиброза экстраокулярных мышц и ретробульбарной клетчатки при ЭОП, что, возможно, сможет улуч-шить диагностику в клинически сложных случаях и при начальных стадиях заболевания. Клю че вые сло ва: эндокринная офтальмопатия, глазодвигательные мышцы, ретробульбарная клетчатка, диагностика.Endocrine ophthalmopathy (EOP) is a progressive autoimmune disease that affects soft retrobulbar tissues in thyroid gland diseases. The statistical data on this disease are presented. The review presents both generally accepted and alternative approaches to the diagnosis of EOP different stages. Detailed clinical symptoms, main severity and activity score classifications of EOP, the required list of physical and instrumental examinations are given. We described the diagnostic value of computed tomography, magnetic resonance imaging, optical coherence tomography, Heidelberg Retina Tomography, radioisotope studies, triplex scanning of the major vessels of the eye, the Doppler mapping method, indocyanine-green angiography, as well as the histological examination of soft retrobulbar tissues biopsy in EOP. Gen...

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Optic nerve head and fibre layer imaging for diagnosing glaucoma

Cited by 74 publications

References 148 publications

Diabetic retinopathy among Brazilian Xavante Indians

Diabetic retinopathy among Brazilian Xavante Indians

Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study

New opportunities in endocrine ophthalmopathy diagnostics (review)

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