Ophthalmologic activity

Vogel, H. Gerhard; Vogel, Wolfgang; Schölkens, Bernward A.; Sandow, J.; Müller, Günter; Vogel, Wolfgang F.

doi:10.1007/3-540-29837-1_16

Cited by 2 publications

(2 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A graduated cylinder was used to collect urine, and the volume was recorded every fve hours and every 24 hours. Fluorescence photometric analysis was used to determine sodium and potassium concentrations, which were represented as mmol/L [26].…”

Section: Evaluation Of Diureticmentioning

confidence: 99%

Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents

Kemisetti

Amin

Alam

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Benzothiazoles, an anticonvulsant, antiviral, antihypertensive, and cancer-fighting medication of the heterocyclic scaffold family, also acts as antibacterial and antiviral agents. There is much interest in this chemical’s production because of the strong and vital biological action it possesses. Substituted aromatic aldehydes were combined with 2-amino-benzothiazole-6-sulfonic acid amides, or Schiff base derivatives, to create Schiff base derivatives. Recrystallized, characterized, and tested for diuretic efficacy in vivo using online tools, m.p. (melting point), Rf, FTIR (Fourier transform infrared), 1H-NMR (proton nuclear magnetic resonance) data The molecular characteristics of all the substances created were estimated using Lipinski’s rule of 5, OSIRIS (software) molecular property explorer, Molsoft, and Autodock 4.0 docking software. Male Wistar rats were used to make all the compounds traditionally in order to test for diuretic activity. Neither the elemental nor the spectral information for the synthesized compounds disagreed. There were five different methods used to evaluate these compounds: Lipinski rule of five, Molsoft to determine molecular characteristics, PASS (prediction of activity spectra for substances) values to determine the diuretic effect, and OSIRIS software to determine toxicology. In order to investigate the diuretic effects of the selected drugs, docking analysis was used. Acetazolamide was shown to have a diuretic effect that was superior to that of compounds IIIb and IIIe, whereas 2-{(E)-[(3-hydroxyphenyl)methylidene]amino}-1,3-benzothiazole-6-sulfonamide (IIIb) was found to be the most promising potential.

show abstract

Section: Evaluation Of Diureticmentioning

confidence: 99%

Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents

Kemisetti

Amin

Alam

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…One hour after the last treatment, a male intruder ~200 g was placed in the territorial cage of the resident male, and behavior of the resident male was observed for the next 15 min. During this period, the time until the first attack in seconds, number of attacks, and duration of each attack in seconds were recorded by a blind observer 26 .…”

Section: Resident-intruder Aggressionmentioning

confidence: 99%

Untitled

2022

IJPSR

View full text Add to dashboard Cite

Aggressive behavior is an important prerequisite for acquiring and maintaining feeding resources, territory and mating partners and, therefore, for the survival of an individual and the species. However, dysregulation of aggression among conspecifics can lead to severe injury and death. Aggression is prominently seen when a disturbance occurs in the fine balance of neurotransmitters such as 5-hydroxytryptamine, gammaaminobutyric acid, dopamine, and receptor subtypes. The current study evaluated the in-vivo anti-aggressive potential of a standardized extract of Alstonia scholaris leaves. The extract of Alstonia scholaris was evaluated for its potential effects against defensive and offensive aggressive behavior models of rodents by oral administration at 250, 500 mg/kg BW dose levels once daily for 14 consecutive days as a suspension in a carboxymethylcellulose CMC, diazepam 1 mg/kg, p.o. was used as a standard anti-aggressive agent. Control group animals were given an equal volume of vehicle 10%, v/v, CMC suspension. The anti-aggressive activity was evaluated using the following validated models of aggression, viz.: Isolation-Induced Aggression, Resident-Intruder Aggression, and Water Competition Test, in Swiss albino mice. As a result, methanolic extract of Alstonia scholaris MAS showed dose dependant anti-aggressive activity in the aforementioned, validated models of aggression. This suggests that the MAS has a promising anti-aggressive activity qualitatively comparable to that of diazepam.

show abstract

Ophthalmologic activity

Cited by 2 publications

References 96 publications

Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents

Novel Benzothiazole Derivatives Synthesis and its Analysis as Diuretic Agents

Untitled

Contact Info

Product

Resources

About