Ophthalmic complications of amniocentesis

Naylor, G; Roper, J P; Willshaw, H E

doi:10.1038/eye.1990.134

Cited by 25 publications

(10 citation statements)

References 14 publications

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“…The only current method for measuring any component of amniotic fluid is by amniocentesis. Although in skilled hands amniocentesis has a low morbidity, severe fetal and maternal injury can result (Anandakumar et al, 1992;Naylor et al, 1990;Galle and Meis, 1982;Kisshern and Benirschke, 1973). Magnetic resonance spectroscopy (MRS) can avoid the risks associated with an invasive procedure such as amniocentesis by providing a non-invasive method for determining the in vivo chemical composition of fetal lung and amniotic fluid.…”

Section: Introductionmentioning

confidence: 99%

Lecithin can be detected by volume-selected proton MR spectroscopy using a 1·5T whole body scanner: a potentially non-invasive method for the prenatal assessment of fetal lung maturity

et al. 1998

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The prenatal determination of fetal lung maturity is currently assessed by chemical analysis of surfactant associated lipids from amniotic fluid obtained by amniocentesis. This is an invasive procedure with rare but occasionally serious morbidity. Magnetic resonance spectroscopy (MRS) is a non‐invasive method for the in vivo localization and identification of molecules with known resonance peaks at specified chemical shifts. In this report we examine the in vitro MRS of a lecithin/saline solution as well as term and preterm amniotic fluid samples with the use of a 1·5T whole body scanner and a flexible surface coil. We found that amniotic fluid at term demonstrates a resonance peak at 3·2ppm which was the same as the chemical shift of lecithin in saline. The lecithin peak is not observed in preterm amniotic fluid. This demonstrates the feasibility of using MRS with a whole body scanner to detect lecithin, one of the markers for fetal lung maturity. Copyright © 1998 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Lecithin can be detected by volume-selected proton MR spectroscopy using a 1·5T whole body scanner: a potentially non-invasive method for the prenatal assessment of fetal lung maturity

et al. 1998

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“…[2][3][4][5][6][7][8] In addition to right basal ganglia lesions, both had oculomotor abnormalities. Both children have a delimited destructive lesion of the right basal ganglia (caudate, putamen, and globus pallidus), similar in extent and severity, thought to be caused by penetration of the fetal brain during amniocentesis at about 17 weeks of gestation.…”

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confidence: 99%

Mid-gestation right basal ganglia lesion

DeLong

2002

Neurology

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The shared behavioral and cognitive syndrome is most reasonably attributed to the right basal ganglia lesions, which were complete and coextensive in both, whereas other lesions were partial, milder, and disparate. Early destruction of the right basal ganglia may preclude normal development of right hemisphere functions without evidence of plasticity and appears associated with intense disinhibition and impulsiveness of aggressive attack activities and with general lability and dyscontrol of emotion.

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“…Long-term follow up has not shown an adverse effect on development or behaviour (Finegan et al 1985). There are many individual case reports of specific injuries such as thoracic puncture (Hyman et al 1973, Cook et al 1974, Leake et al 1974, Achiron and Zakut 1986, vascular damage with arterio-venus fistula formation (Gottdiener et al 1975), and damage to the eyes (BenEzra et al 1989, Naylor et al 1990, Hershey 1993, Rummelt et al 1993. Reports of injury to the fetal brain are rare with only seven cases described to our knowledge, five of these cases were associated with midtrimester amniocentesis and two in the last trimester (Creasman et al 1968, Portman andBrouillette 1982).…”

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Five cases of brain injury following amniocentesis in mid‐term pregnancy

Squier¹,

Chamberlain

Zaiwalla³

et al. 2000

Develop Med Child Neuro

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This paper describes the neuroimaging and neuropathological findings in five cases of severe brain damage after traumatic mid‐trimester amniocentesis, all performed between 1986 and 1994. Although fetal injury after amniocentesis has been reported, reports of brain injury are infrequent. Continuous ultrasound monitoring may reduce the risk of fetal injury but follow‐up ultrasound scans can be falsely reassuring. Withdrawal of blood‐stained fluid, particularly if it contains tissue fragments, should alert the operator to the possibility of fetal damage. Histological examination of such tissue fragments may confirm the nature of the fetal damage. The consequences of fetal brain injury are severe, all five of our cases showed evidence of disruption of brain development compatible with mid‐term injury. Obstetricians and their patients should be aware of the small but significant risk of brain damage after mid‐term amniocentesis.

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Ophthalmic complications of amniocentesis

Cited by 25 publications

References 14 publications

Lecithin can be detected by volume-selected proton MR spectroscopy using a 1·5T whole body scanner: a potentially non-invasive method for the prenatal assessment of fetal lung maturity

Lecithin can be detected by volume-selected proton MR spectroscopy using a 1·5T whole body scanner: a potentially non-invasive method for the prenatal assessment of fetal lung maturity

Mid-gestation right basal ganglia lesion

Five cases of brain injury following amniocentesis in mid‐term pregnancy

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