Lecithin can be detected by volume-selected proton MR spectroscopy using a 1·5T whole body scanner: a potentially non-invasive method for the prenatal assessment of fetal lung maturity

Fenton, Bradford W.; Lin, Chin-Shoou; Seydel, Frank; Macedonia, Christian

doi:10.1002/(sici)1097-0223(199812)18:12<1263::aid-pd444>3.0.co;2-2

Cited by 24 publications

(5 citation statements)

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“…The application of spectroscopy to fetal lungs is limited to research [15,16]. Although hampered by fetal motion, it seems to have potential in the evaluation of lung maturation by estimating the amount of choline-containing compounds, a component of lung surfactant.…”

Section: Spectroscopymentioning

confidence: 99%

Magnetic resonance imaging of the fetal lung: a pictorial essay

et al. 2008

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Ultrasound, which is now a widely available and generally accepted, low-cost technique with real-time properties, is the screening investigation of choice in fetal medicine. However, enthusiasm for fetal prenatal magnetic resonance imaging (MRI) is rising, because of the absence of known biological risks, the increasing ease of performing of fetal MRI and the superb contrast resolution provided. Over the last 10 years, the technology has advanced dramatically. Fast imaging sequences have allowed better MRI visualization of the unborn patient than ever before. As a consequence, experience with fetal MRI is gradually expanding. We are beginning to appreciate the clinical conditions where fetal MRI can complement the ultrasound findings. Apart from the central nervous system, MRI of the fetal lung has received the most attention. Fetal MRI can be used to assess thoracic structural anomalies, lung development as well as maturation. The introduction of fetal therapy for severe lung hypoplasia, associated with congenital diaphragmatic hernia (CDH), has recently boosted the application. This review aims to highlight MRI techniques used to image the lungs of the unborn child and to point out their strengths and limitations in specific conditions.

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Section: Spectroscopymentioning

confidence: 99%

Magnetic resonance imaging of the fetal lung: a pictorial essay

et al. 2008

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“…Surfactant deficiency is associated with respiratory distress syndrome in premature newborns and may occur in other disorders such as CDH [34,35]. Estimation of lung maturity has been attempted by assaying surfactant-related metabolites in amniotic fluid [36][37][38]. Whilst the epithelium has absorbed much scientific interest for conferring tissue specialisation (liquid production, surfactant manufacture), the pulmonary mesenchyme is essential to lung development [39].…”

Section: An Overview Of Lung Development Reveals Points Of Clinical Imentioning

confidence: 99%

Exploiting mechanical stimuli to rescue growth of the hypoplastic lung

Jesudason

2007

Pediatr Surg Int

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Impaired lung development afflicts a range of newborns cared for by paediatric surgeons. As a result the speciality has led in the development of surgical models that illustrate the biomechanical regulation of lung growth. Using transgenic mutants, biologists have similarly discovered much about the biochemical regulation of prenatal lung growth. Airway smooth muscle (ASM) and its prenatal contractility airway peristalsis (AP) represent a novel link between these areas: ASM progenitors produce an essential biochemical factor for lung morphogenesis, whilst calcium-driven biomechanical ASM activity appears to regulate the same. In this invited paper, I take the opportunity both to review our recent findings on lung growth and prenatal ASM, and also to discuss mechanisms by which ASM contractility can regulate growth. Finally, I will introduce some novel ideas for exploration: ASM contractility could help to schedule parturition (pulmonary parturition clock) and could even be a generic model for smooth muscle regulation of morphogenesis in similar organs.

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“…Phosphatidylcholine in amniotic fluid has a characteristic MR spectroscop y peak at 3.2 pp m [10]; this c haracteris tic reproducible location of the peak on a spectrum prevents confounding variables such as blood from interfering with the ability to detect choline-containing compounds. Potential benefits to performing MR imaging and spectroscopy include the confirmation of laboratory findings and incidental assessment of fetal anatomy.…”

Section: Discussionmentioning

confidence: 99%