Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity

Clifton, Matthew S.; Joe, Bonnie N.; Zektzer, Andrew S.; Kurhanewicz, John; Vigneron, Daniel B.; Coakley, Fergus V.; Nobuhara, Kerilyn K.; Swanson, Mark G.

doi:10.1016/j.jpedsurg.2006.02.020

Cited by 40 publications

(32 citation statements)

References 9 publications

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“…Surfactant deficiency is associated with respiratory distress syndrome in premature newborns and may occur in other disorders such as CDH [34,35]. Estimation of lung maturity has been attempted by assaying surfactant-related metabolites in amniotic fluid [36][37][38]. Whilst the epithelium has absorbed much scientific interest for conferring tissue specialisation (liquid production, surfactant manufacture), the pulmonary mesenchyme is essential to lung development [39].…”

Section: An Overview Of Lung Development Reveals Points Of Clinical Imentioning

confidence: 99%

Exploiting mechanical stimuli to rescue growth of the hypoplastic lung

Jesudason

2007

Pediatr Surg Int

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Impaired lung development afflicts a range of newborns cared for by paediatric surgeons. As a result the speciality has led in the development of surgical models that illustrate the biomechanical regulation of lung growth. Using transgenic mutants, biologists have similarly discovered much about the biochemical regulation of prenatal lung growth. Airway smooth muscle (ASM) and its prenatal contractility airway peristalsis (AP) represent a novel link between these areas: ASM progenitors produce an essential biochemical factor for lung morphogenesis, whilst calcium-driven biomechanical ASM activity appears to regulate the same. In this invited paper, I take the opportunity both to review our recent findings on lung growth and prenatal ASM, and also to discuss mechanisms by which ASM contractility can regulate growth. Finally, I will introduce some novel ideas for exploration: ASM contractility could help to schedule parturition (pulmonary parturition clock) and could even be a generic model for smooth muscle regulation of morphogenesis in similar organs.

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Section: An Overview Of Lung Development Reveals Points Of Clinical Imentioning

confidence: 99%

Exploiting mechanical stimuli to rescue growth of the hypoplastic lung

Jesudason

2007

Pediatr Surg Int

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“…La quantification de ce pic de lécithine pourrait être un reflet de la maturation pulmonaire [69]. La spectroscopie de résonance sera sans doute très bientôt un moyen non-invasif fiable de quantifier les composants du liquide amniotique et du poumon foetal qui contiennent de la choline, composant principal du surfactant [70]. Cette piste de recherche nous semble définitivement la plus prometteuse.…”

Section: Spectroscopieunclassified

Évaluation du poumon fœtal en imagerie

Pasquali¹,

Potier²,

Gorincour³

2008

Gynécologie Obstétrique & Fertilité

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“…Previous NMR studies have shown a correlation between human amniotic fluid composition and disorders such as open spinabifida [18,19] and diabetes mellitus [20], as well as foetal lung [21] and kidney [18] maturation and normative metabolite concentration during gestation [22]. This method provides a coherent view of the complete metabolic response of organisms to physiological and pathophysiological stimuli.…”

Section: Introductionmentioning

confidence: 99%