Ophthalmic Artery Blood Flow Parameters in Pseudoexfoliation Glaucoma

Kocatürk, Tolga; Isikligil, Isil; Uz, Burçin; Dayanir, Volkan; Dayanir, Yelda Özsunar

doi:10.5301/ejo.5000671

Cited by 21 publications

(17 citation statements)

References 32 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…25 Impaired retrobulbar hemodynamics have been identified in exfoliation syndrome and exfoliation glaucoma. [26][27][28] However, these methods have not been established in everyday clinical practice for various reasons, e.g., due to invasiveness (fluorescein angiography) or, especially, because an individual diagnosis is not possible on the basis of circulatory abnormalities alone or because of a lack of quantifiable parameters. Owing to these difficulties, the diagnosis of perfusion disorders is often based on the presence of indirect signs such as vasospastic syndrome, arterial hypotension, migraine, or tinnitus.…”

Section: Discussionmentioning

confidence: 99%

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Lommatzsch

Rothaus

et al. 2019

OPTH

View full text Add to dashboard Cite

Purpose: To compare papillary and macular vessel density (VD), as measured by optical coherence tomography angiography (OCTA), in eyes with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and exfoliation glaucoma (XFG). Methods: The papillary and macular VD of 40 eyes with POAG, 19 with NTG and 21 with XFG were examined using OCTA (AngioVue™). The VD was measured at two different layers of segmentation (optic nerve head: radial peripapillary capillary [RPC] and nerve head [NH]; macula: superficial [SL] and deep [DL] retinal vascular plexus) with a 4.5×4.5mm papillary and 6×6-mm macular scan. VD was calculated by an automated density measuring tool in the AngioVue™ software.Results: There were no significant differences in the total value of the papillary, peripapillary and macular VD. A significantly higher VD could be measured for NTG compared to POAG, as well as for XFG in the inferior nasal peripapillary sector at RPC-segmentation and at the NH-level between NDG and XFG. Conclusion: OCTA can detect a difference in VD in the nasal inferior peripapillary sector in NTG compared with POAG and XFG. These findings may help to improve the understanding of further pathophysiological mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Lommatzsch

Rothaus

et al. 2019

OPTH

View full text Add to dashboard Cite

show abstract

“…Studies have not only demonstrated that PEX material is correlated with vascular dysfunction, but have also identified it as an independent risk factor (6). In a recent study comparing ophthalmic arterial hemodynamics and vascular resistance in eyes with PEX and healthy eyes, Kocaturk et al (12) reported an increase in vascular resistance and disruption of hemodynamic parameters in PEX eyes. The results of our study corroborate previous studies demonstrating retinal blood flow abnormalities in patients with PEX compared with healthy individuals (6,10,11,12).…”

Section: Discussionmentioning

confidence: 99%

Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography

Çınar¹,

Yüce²,

Aslan³

2019

Balkan Med J

View full text Add to dashboard Cite

Background: Optical coherence tomography angiography allows a detailed evaluation of retinal and choroidal microvascular structures without the need for a contrast agent. Pseudoexfoliation syndrome is a condition that leads to anatomical and functional losses due to accumulation of degraded abnormal fibrillar material in the intraocular and extraocular tissues. Histopathological studies have shown that the accumulation of Pseudoexfoliation syndrome material in the vascular structures may play a role in different ocular pathologies such as retinal vein occlusion, iris hypoperfusion, anterior segment hypoxia, retinal arterial occlusion, and neovascular glaucoma. Aims: To evaluate and compare flow and vascular density in the retina and choroid in eyes with Pseudoexfoliation syndrome, fellow eyes without Pseudoexfoliation syndrome, and healthy eyes using optical coherence tomography angiography. Study Design: Case control study. Methods: The study included 35 eyes with Pseudoexfoliation syndrome of 35 Pseudoexfoliation syndrome patients, 32 fellow eyes without Pseudoexfoliation syndrome of 32 unilateral Pseudoexfoliation syndrome patients, and 35 eyes of healthy control subjects. Flow area and vascular density in the superficial capillary plexus and deep capillary plexus were measured by optical coherence tomography angiography as three separate parameters: total, parafoveal, and foveal. Choroidal thickness and foveal avascular zone area were measured for each patient. Results: There were significant differences between the Pseudoexfoliation syndrome eyes and control eyes in total, parafoveal, and foveal flow and vascular density in the superficial capillary plexus (p<0.05 for all), while there were no significant differences between these groups in any of the flow or vascular density values in the deep capillary plexus (p>0.05). None of the superficial capillary plexus and deep capillary plexus flow and vascular density values showed significant differences between Pseudoexfoliation syndrome eyes and non-Pseudoexfoliation syndrome fellow eyes or between the non-Pseudoexfoliation syndrome fellow eyes and control eyes (p>0.05). Choroidal thickness was significantly lower in Pseudoexfoliation syndrome eyes compared to control eyes. Foveal avascular zone area was significantly enlarged in Pseudoexfoliation syndrome eyes compared to control eyes in both the superficial and deep layers (p<0.05). Conclusion: Pseudoexfoliation syndrome eyes exhibit significant damage to the retinal and choroidal vascular structures.

show abstract

“…The mean velocity and the resistivity index (RI) are the two important parameters that can be followed, except that RI does not accurately correlate with the resistance offered by the ophthalmic vessels [ 17 , 18 ]. Kocaturk et al reported increased vascular resistance in OA in pseudoexfoliation glaucoma [ 19 ]. Many studies demonstrated that the blood flow resistance was increased and blood flow velocities were decreased in the OA and SPCAs of patients with POAG, pseudoexfoliation syndrome, and NTG [ 9 , 17 – 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Kocaturk et al reported increased vascular resistance in OA in pseudoexfoliation glaucoma [ 19 ]. Many studies demonstrated that the blood flow resistance was increased and blood flow velocities were decreased in the OA and SPCAs of patients with POAG, pseudoexfoliation syndrome, and NTG [ 9 , 17 – 19 ]. Reduced blood flow velocities and increased RI in retrobulbar vessels in patients with NTG may explain the reason for the ONH fluorescein filling defects and capillary loss of the ONH of these patients [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Foveal Avascular Zone in Normal Tension Glaucoma Measured by Optical Coherence Tomography Angiography

Zivkovic

Dayanir²,

Kocatürk

et al. 2017

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Aim To measure diameter of foveal avascular zone (FAZ), FAZ area, and vessel density using Optical Coherence Tomography Angiography (OCT-A) in patients with normal tension glaucoma (NTG) and to establish the possible role of OCT-A in diagnosis and follow-up of patients with NTG. Methods Twenty-one eyes of 21 patients with NTG and 30 eyes of 30 healthy subjects underwent complete ophthalmic examination as well as OCT-A on ZEISS AngioPlex. 3 × 3 macula scans were used to measure vertical, horizontal, and maximum diameter of FAZ by two graders. Mean values and interobserver variability were analyzed. Image J was used for analysis of FAZ area and vessel density. Results Mean vertical diameter (t = 5.58, p < 0.001), horizontal diameter (t = 3.59, p < 0.001), maximum diameter (t = 5.94, p < 0.001), and FAZ area (t = 5.76, p < 0.001) were statistically significantly enlarged in the NTG group compared to those in the control group. Vessel density (t = −5.80, p < 0.001) was statistically significantly decreased in the NTG group compared to that in the control group. Conclusion OCT-A could have an important role in the future in diagnosis of patients with NTG. In patients with NTG, there is larger FAZ area, while the vessel density is reduced in comparison to the control group.

show abstract

Ophthalmic Artery Blood Flow Parameters in Pseudoexfoliation Glaucoma

Abstract: The results support the findings of increased vascular resistance in OA XFG. High sensitivity and specificity obtained for OA RI may be useful in evaluation of future therapeutic vascular agents.

Cited by 21 publications

References 32 publications

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: a Comparative Study Using Optical Coherence Tomography Angiography

Foveal Avascular Zone in Normal Tension Glaucoma Measured by Optical Coherence Tomography Angiography

Contact Info

Product

Resources

About