Purpose: To compare papillary and macular vessel density (VD), as measured by optical coherence tomography angiography (OCTA), in eyes with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and exfoliation glaucoma (XFG). Methods: The papillary and macular VD of 40 eyes with POAG, 19 with NTG and 21 with XFG were examined using OCTA (AngioVue™). The VD was measured at two different layers of segmentation (optic nerve head: radial peripapillary capillary [RPC] and nerve head [NH]; macula: superficial [SL] and deep [DL] retinal vascular plexus) with a 4.5×4.5mm papillary and 6×6-mm macular scan. VD was calculated by an automated density measuring tool in the AngioVue™ software.Results: There were no significant differences in the total value of the papillary, peripapillary and macular VD. A significantly higher VD could be measured for NTG compared to POAG, as well as for XFG in the inferior nasal peripapillary sector at RPC-segmentation and at the NH-level between NDG and XFG. Conclusion: OCTA can detect a difference in VD in the nasal inferior peripapillary sector in NTG compared with POAG and XFG. These findings may help to improve the understanding of further pathophysiological mechanisms.

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A case of bilateral complete cryptophthalmos combined with other malformations is described. The clinical appearance, histology, and the results of computed tomography and electro-ophthalmological investigations are communicated.

A 68 year old female with aphakic soft lenses on an extended wear basis developed an Acanthamoeba-keratitis. The diagnosis could be confirmed by a positive culture of a corneal smear, the contact lens and the care solution. Immediate antibiotic therapy including aminoglycosides and cephalosporines topically showed response with clearing of the stromale infiltrates and, as a residuum, the development of small stromal scars at the former site of inflammation. An Acanthamoeba-keratitis should be considered in the differential diagnosis of all cases of keratitis in contact lens wearers that are unresponsive to topical medical therapy and without bacterial growth on routine cultures.

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