Operative Therapy of a Monstrous Buschke-Löwenstein Tumor

Klein, Neil C.; Jasch, Kim C; Kimmritz, J.; Hermes, Bárbara; Harth, W.

doi:10.1159/000106589

Cited by 7 publications

(3 citation statements)

References 11 publications

(11 reference statements)

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“…The wide local excision of the tumor with subsequent histological examination of the resection margins is the most suitable method of treatment for GCA, similar to treatment of other malignancies [6, 7]. In the literature reviews, surgical treatment leads to a recurrence rate of 50% (26 of 52 cases [4] and 8 of 16 cases [6]) whereas the overall rate of recurrence (including surgery, topical treatment and radiochemotherapy) is 67% (28 of 42 patients) [6].…”

Section: Discussionmentioning

confidence: 99%

Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies

Gholam¹,

Enk²,

Hartschuh³

2008

Dermatology

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Giant condyloma acuminatum (GCA; Buschke-Löwenstein tumor) is a human-papillomavirus-induced cauliflower-like tumor of the genitoanal region. It is characterized by its size, capability of local infiltration and high recurrence rate. We report on a 50-year-old patient presenting with a maximum finding of GCA with deep infiltration into the adductor and perineal musculature, the scrotum, the penis and the pararectum. After performing a temporary loop colostomy, the tumor was removed by wide radical excision following plastic reconstruction with a myocutaneous gracilis flap. During a follow-up period of more than 5 years, no recurrence developed. Many treatment strategies (e.g. chemotherapy, radiation) have been published in the literature. Most authors recommend the radical surgical excision, allowing a complete histological examination and assessment of tumor-free resection margins. Despite the benign histological pattern of GCA in most cases, transformations into verrucous carcinoma and squamous-cell carcinoma have been described. In our case, the GCA seems to represent a continuum between normal condyloma acuminatum and an initial verrucous carcinoma.

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Section: Discussionmentioning

confidence: 99%

Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies

Gholam¹,

Enk²,

Hartschuh³

2008

Dermatology

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“…Wide local excision remains to be the treatment of choice, as local control usually leads to good prognosis. Surgery has been reported to have a dis- ease-free status in 45.5% of patients [15,16]. Other treatment modalities include chemotherapy (systemic and intralesional), carbon dioxide laser therapy, and photodynamic therapy, although their effects have not yet been established.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of surgical management of buschke-lowenstein tumor in a Philippine tertiary hospital

et al. 2022

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Buschke-Lowenstein tumor (BLT) is a sexually transmitted infection (STI) caused by the human papillomavirus. This study investigated the profile, management, and outcomes of patients who underwent surgery for BLT from 2015 to 2019 at the Philippine General Hospital. Seven patients underwent surgery for BLT. All were male, with ages ranging from 21 to 41 years. Presenting symptoms were anal mass, foul-smelling discharge, pain, bleeding, and pruritus. All were positive for human immunodeficiency virus. All admitted to having engaged in both insertive and receptive anal intercourse, with multiple partners. All underwent excision with healing by secondary intention. Two had recurrence of warts. Four had an anal stricture. Of these, 3 underwent anal dilatation, while 1 had to undergo proximal bowel diversion. One had intraepithelial carcinoma without dermal invasion on histopathologic analysis. BLT is a rare STI characterized by local aggressiveness but with low malignant potential. Wide excision remains to be the mainstay of treatment.

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“…It is histologically benign and when it is diagnosed at an early stage can be treated with wide local excision [2,3]. Some authors believe that the biological behavior of the BLT is an intermediate form between condyloma acuminatum and squamous cell carcinoma [4].…”

Section: Introductionmentioning

confidence: 99%

Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases

et al. 2013

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Treatment of anorectal Buschke-Löwenstein tumor (BLT) with squamous cell carcinoma (SCC) transformation is not univocal given the rarity of the disease. BLT is characterized by its large size and tendency to infiltrate into underlying tissues. Malignant transformation can occur and it is important to identify the presence of neoplastic foci to decide the proper treatment. Our aim was to assess the effectiveness of neo-adjuvant chemo-radiation therapy (CRT) and local excision in order to avoid abdomino-perineal resection (APR). Three cases of anorectal BLT with SCC transformation are presented. All patients were HIV positive and treated with antiretroviral drugs. They underwent preoperative endoanal ultrasound, biopsies, total body tomography and anal brushing. Treatment consisted of neo-adjuvant chemo-radiation therapy (45 Gy to the pelvis plus a boost with 14.40 Gy to the primary tumor for a total of 59.40 Gy, and mitomycin-C in bolus on the first day, plus 5-fluorouracil by continuous infusion in the first and in the sixth week) and subsequent local surgical excision. During the follow-up, patients were subjected to the same preoperative diagnostic investigations and high resolution anoscopy. All patients showed a complete regression of the lesion after CRT and were treated by local surgical excision, thus avoiding permanent colostomy. In conclusion neo-adjuvant chemo-radiation therapy with local surgical excision could be considered an effective therapy in the treatment of anorectal BLT with SCC transformation to avoid APR.

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Operative Therapy of a Monstrous Buschke-Löwenstein Tumor

Cited by 7 publications

References 11 publications

Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies

Successful Surgical Management of Giant Condyloma Acuminatum (Buschke-Löwenstein Tumor) in the Genitoanal Region: A Case Report and Evaluation of Current Therapies

Outcomes of surgical management of buschke-lowenstein tumor in a Philippine tertiary hospital

Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases

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