Open-label observational study of the homeopathic medicine Passiflora Compose for anxiety and sleep disorders

Villet, Stéphanie; Vacher, Véronique; Colas, Aurélie; Danno, Karine; Masson, Jean-Louis; Marijnen, Philippe; Bordet, Marie-France

doi:10.1016/j.homp.2015.07.002

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…Several herbs have been reported to have a sedative or sleep-promoting capacity: valerian (Valeriana officinalis), hops (Humulus lupulus), German chamomile (Matricaria recutita), passionflower (Passiflora incarnata), and Polygonatum sibiricum. [12][13][14][15] Our previous study revealed that the mixture of Lactuca sativa and skullcap extracts played an active role in sleep promotion. 16) In this study, we focus on the sleep-promoting effect of romaine lettuce and its mechanisms by investigating antagonistic behaviors on sleep-related receptors.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Kim

Suh

Hyun-Min

et al. 2019

Biological & Pharmaceutical Bulletin

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This study was conducted to investigate the effects of the extracts of green romaine lettuce (GRE) on sleep enhancement. GRE contains 1071.7 and 199.2 µg/g of extracts of lactucin and lactucopicrin, respectively, known as sleep enhancement substances. When 100 mg/kg of GRE was administered orally, sleep latency and duration time were significantly increased compared to controls (p < 0.05). Rapid eye movement (REM) sleep decreased with 100 mg/kg of GRE administration and non-REM (NREM) sleep also increased. There was no significant difference between REM and NREM among the oral GRE administration groups receiving 100, 120, and 160 mg/kg GRE. In the caffeine-induced insomnia model, total sleep time was significantly increased by 100 mg/kg GRE administration compared to the caffeine-treated group (p < 0.05). In addition, GRE inhibited the binding of [ 3 H]-flumazenil in a concentration-dependent manner, and affinity of both lactucin and lactucopicrin to gamma-aminobutyric acid (GABA) A-benzodiazepine (BDZ) receptor was 80.7% and 55.9%, respectively. Finally, in the pentobarbital-induced sleep mouse model, the sleep enhancement effect of GRE was inhibited by flumazenil, an antagonist of BDZ. Thus, these results demonstrate that GRE acts via a GABAergic mechanism to promote sleep in a rodent model.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Kim

Suh

Hyun-Min

et al. 2019

Biological & Pharmaceutical Bulletin

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“…Herbal medicine is one of the most frequently used interventions for the treatment of insomnia for thousands of years (Shi et al, 2014). For instance, valerian (Valeriana officinalis) roots, alone or in combination with hops (Humulus lupulus L.), chamomile (Matricaria chamomilla), and passion flower (Passiflora), has been used as calming and sleep-promoting herbs (Abourashed et al, 2004;Srivastava et al, 2010;Villet et al, 2016). These herbal treatments have been reported to induce sedative effects via c-aminobutyric acid-ergic (GABAergic) or serotonergic neurotransmission regulation in animals and humans (Attele et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Kim

Hyun-Min

et al. 2018

Food Sci Biotechnol

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The aim of this study was to identify sleeppromoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleeppromoting activity was found to be involved in the GABA A -BDZ receptor. The chemical structure of the pure compound was determined by the 1 H and 13 C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1monolinoleate showed a similar inhibitory concentration on [ 3 H]-flumazenil binding to GABA A -BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.

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“…Enquanto pacientes diagnosticados com sintomas mais graves foram orientados a usar tanto o fitoterápico quanto psicotrópicos. Todavia, a melhora da ansiedade e dos distúrbios do sono foram estatisticamente mais favoráveis para pacientes que fizeram uso apenas da P. incarnata, embora os que a utilizavam isoladamente ainda apresentassem sintomas mais leves (Villet et al, 2016).…”

Section: Fonte: Autores (2022)unclassified

Passiflora incarnata no tratamento da ansiedade e no distúrbio do sono

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Santos

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2022

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Popularmente conhecida pela sua flor como “flor da paixão”, e pelo seu fruto como “maracujá”, a Passiflora incarnata L, pertencente à família Passifloraceae, é uma espécie nativa da América do Sul, Austrália e Sudeste Asiático. Segundo evidências científicas, a Passiflora incarnata tem sido utilizada na fitoterapia desde meados do século XIX na Europa Ocidental, e estudos atuais reafirmam os efeitos terapêuticos sob a inquietação nervosa, transtorno de déficit de atenção e hiperatividade, ansiedade pré-operatória, e até mesmo nos sintomas da menopausa. Assim, por meio de uma revisão bibliográfica do tipo integrativa, o presente estudo teve como principal objetivo descrever, de acordo com a literatura, a utilização da Passiflora incarnata para o tratamento da ansiedade e do distúrbio do sono. De acordo com os resultados observou-se que a Passiflora incarnata pode ser uma opção viável para o tratamento alternativo de alguns pacientes com sintomas de ansiedade, desde que seja considerada a evolução do transtorno e o uso ou não de psicotrópicos. Uma vez que esta espécie apresenta ação ansiolítica agindo como depressor inespecífico do sistema nervoso central. Entretanto, embora seu uso de forma geral seja eficiente e seguro, ainda se salienta que quando o uso é realizado de forma errônea existem possibilidades da aparição de princípios tóxicos e geração de graves problemas referentes ao seu uso indiscriminado. Tornando-se essencial o acompanhamento e orientação de um profissional farmacêutico.

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Open-label observational study of the homeopathic medicine Passiflora Compose for anxiety and sleep disorders

Abstract: Anxiety and/or SDS improved significantly in patients included on this study. PC could be an alternative to the use of psychotropic drugs for first intention treatment of anxiety and SDS. Further studies are needed to confirm those results.

Cited by 12 publications

References 11 publications

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Effectiveness of the Sleep Enhancement by Green Romaine Lettuce (<i>Lactuca sativa</i>) in a Rodent Model

Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome

Passiflora incarnata no tratamento da ansiedade e no distúrbio do sono

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